Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases

ObjectiveImmune-mediated inflammatory diseases (IMIDs) are heterogeneous and complex conditions with overlapping clinical symptoms and elevated familial aggregation, which suggests the existence of a shared genetic component. In order to identify this genetic background in a systematic fashion, we p...

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Veröffentlicht in:	Annals of the rheumatic diseases 2019-03, Vol.78 (3), p.311-319
Hauptverfasser:	Acosta-Herrera, Marialbert, Kerick, Martin, González-Serna, David, Wijmenga, Cisca, Franke, Andre, Gregersen, Peter K, Padyukov, Leonid, Worthington, Jane, Vyse, Timothy James, Alarcón-Riquelme, Marta Eugenia, Mayes, Maureen D, Martin, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alpha Karyopherins - immunology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoimmunity Chromatin Cytoskeleton Deoxyribonuclease Disease Epidermal growth factor Female Gene expression Gene loci Genetic Predisposition to Disease Genome-Wide Association Study Genomes Growth factors Haplotypes Health risk assessment Human health and pathology Humans Hypersensitivity Hypertension Immunosuppressive agents Inflammatory diseases Interferon Kinases Life Sciences LIM kinase Lim Kinases - immunology Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Male Membrane Proteins - immunology Meta-analysis Methotrexate Myositis - genetics Myositis - immunology Parasitology Polymorphism, Single Nucleotide Population Proteins Quality control Quantitative trait loci Quantitative Trait Loci - genetics Quantitative Trait Loci - immunology Repressor Proteins - immunology Rheumatic diseases Rheumatic Diseases - genetics Rheumatic Diseases - immunology Rheumatoid arthritis Rheumatology Rhumatology and musculoskeletal system Scleroderma Scleroderma, Systemic - genetics Scleroderma, Systemic - immunology Single-nucleotide polymorphism Software Studies Systemic lupus erythematosus Systemic sclerosis Whites - genetics
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