Gallstones and incident colorectal cancer in a large pan‐European cohort study
Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. Ho...
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| Veröffentlicht in: | International journal of cancer 2019-09, Vol.145 (6), p.1510-1516 |
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| creator | Ward, Heather A Murphy, Neil Weiderpass, Elisabete Leitzmann, Michael F Aglago, Elom Gunter, Marc J Freisling, Heinz Jenab, Mazda Boutron‐Ruault, Marie‐Christine Severi, Gianluca Carbonnel, Franck Kühn, Tilman Kaaks, Rudolf Boeing, Heiner Tjønneland, Anne Olsen, Anja Overvad, Kim Merino, Susana Zamora‐Ros, Raul Rodríguez‐Barranco, Miguel Dorronsoro, Miren Chirlaque, Maria‐Dolores Barricarte, Aurelio Perez‐Cornago, Aurora Trichopoulou, Antonia Bamia, Christina Lagiou, Pagona Masala, Giovanna Grioni, Sara Tumino, Rosario Sacerdote, Carlotta Mattiello, Amalia Bueno‐de‐Mesquita, Bas Vermeulen, Roel Van Gils, Carla Nyström, Hanna Rutegård, Martin Aune, Dagfinn Riboli, Elio Cross, Amanda J |
| description | Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclear whether gallstones are a risk factor for CRC. We examined the association between history of gallstones and CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a prospective cohort of over half a million participants from ten European countries. History of gallstones was assessed at baseline using a self‐reported questionnaire. The analytic cohort included 334,986 participants; a history of gallstones was reported by 3,917 men and 19,836 women, and incident CRC was diagnosed among 1,832 men and 2,178 women (mean follow‐up: 13.6 years). Hazard ratios (HR) and 95% confidence intervals (CI) for the association between gallstones and CRC were estimated using Cox proportional hazards regression models, stratified by sex, study centre and age at recruitment. The models were adjusted for body mass index, diabetes, alcohol intake and physical activity. A positive, marginally significant association was detected between gallstones and CRC among women in multivariable analyses (HR = 1.14, 95%CI 0.99–1.31, p = 0.077). The relationship between gallstones and CRC among men was inverse but not significant (HR = 0.81, 95%CI 0.63–1.04, p = 0.10). Additional adjustment for details of reproductive history or waist circumference yielded minimal changes to the observed associations. Further research is required to confirm the nature of the association between gallstones and CRC by sex.
What's new?
Gallstones can be extremely painful. But might the inflammation they cause also increase the risk of colorectal cancer (CRC)? Previous results have been inconsistent. In this large, prospective study, the authors found a slight positive association between gallstones and CRC among women. For men, on the other hand, there was an inverse association, but the data didn't reach statistical significance. More research is needed to confirm and further explore these sex‐based differences. |
| doi_str_mv | 10.1002/ijc.32090 |
| format | Article |
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What's new?
Gallstones can be extremely painful. But might the inflammation they cause also increase the risk of colorectal cancer (CRC)? Previous results have been inconsistent. In this large, prospective study, the authors found a slight positive association between gallstones and CRC among women. For men, on the other hand, there was an inverse association, but the data didn't reach statistical significance. More research is needed to confirm and further explore these sex‐based differences.</description><identifier>ISSN: 0020-7136</identifier><identifier>ISSN: 1097-0215</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.32090</identifier><identifier>PMID: 30585640</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Alcoholic beverages ; Alcohols ; Body mass ; Body mass index ; Calculi ; Cancer ; cohort ; Cohort analysis ; Cohort Studies ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - complications ; Colorectal Neoplasms - epidemiology ; Complications ; Diabetes ; Diabetes mellitus ; EPIC ; Europe - epidemiology ; Female ; Gallstones ; Gallstones - complications ; Gallstones - epidemiology ; Health risk assessment ; Health risks ; Humans ; Incidence ; Male ; Medical research ; Medicin och hälsovetenskap ; Middle Aged ; Physical activity ; Proportional Hazards Models ; Registries ; Regression analysis ; Risk Factors ; Smoking</subject><ispartof>International journal of cancer, 2019-09, Vol.145 (6), p.1510-1516</ispartof><rights>2018 UICC</rights><rights>2018 UICC.</rights><rights>2019 UICC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5140-be3aa97cdb29d9c8852296211f85094308c303bf08b60296d5f9393268d76493</citedby><cites>FETCH-LOGICAL-c5140-be3aa97cdb29d9c8852296211f85094308c303bf08b60296d5f9393268d76493</cites><orcidid>0000-0002-8008-5096 ; 0000-0003-3347-8249 ; 0000-0002-6236-6804 ; 0000-0002-2721-2404 ; 0000-0002-3646-8006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.32090$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.32090$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,552,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30585640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162390$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:141462354$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ward, Heather A</creatorcontrib><creatorcontrib>Murphy, Neil</creatorcontrib><creatorcontrib>Weiderpass, Elisabete</creatorcontrib><creatorcontrib>Leitzmann, Michael F</creatorcontrib><creatorcontrib>Aglago, Elom</creatorcontrib><creatorcontrib>Gunter, Marc J</creatorcontrib><creatorcontrib>Freisling, Heinz</creatorcontrib><creatorcontrib>Jenab, Mazda</creatorcontrib><creatorcontrib>Boutron‐Ruault, Marie‐Christine</creatorcontrib><creatorcontrib>Severi, Gianluca</creatorcontrib><creatorcontrib>Carbonnel, Franck</creatorcontrib><creatorcontrib>Kühn, Tilman</creatorcontrib><creatorcontrib>Kaaks, Rudolf</creatorcontrib><creatorcontrib>Boeing, Heiner</creatorcontrib><creatorcontrib>Tjønneland, Anne</creatorcontrib><creatorcontrib>Olsen, Anja</creatorcontrib><creatorcontrib>Overvad, Kim</creatorcontrib><creatorcontrib>Merino, Susana</creatorcontrib><creatorcontrib>Zamora‐Ros, Raul</creatorcontrib><creatorcontrib>Rodríguez‐Barranco, Miguel</creatorcontrib><creatorcontrib>Dorronsoro, Miren</creatorcontrib><creatorcontrib>Chirlaque, Maria‐Dolores</creatorcontrib><creatorcontrib>Barricarte, Aurelio</creatorcontrib><creatorcontrib>Perez‐Cornago, Aurora</creatorcontrib><creatorcontrib>Trichopoulou, Antonia</creatorcontrib><creatorcontrib>Bamia, Christina</creatorcontrib><creatorcontrib>Lagiou, Pagona</creatorcontrib><creatorcontrib>Masala, Giovanna</creatorcontrib><creatorcontrib>Grioni, Sara</creatorcontrib><creatorcontrib>Tumino, Rosario</creatorcontrib><creatorcontrib>Sacerdote, Carlotta</creatorcontrib><creatorcontrib>Mattiello, Amalia</creatorcontrib><creatorcontrib>Bueno‐de‐Mesquita, Bas</creatorcontrib><creatorcontrib>Vermeulen, Roel</creatorcontrib><creatorcontrib>Van Gils, Carla</creatorcontrib><creatorcontrib>Nyström, Hanna</creatorcontrib><creatorcontrib>Rutegård, Martin</creatorcontrib><creatorcontrib>Aune, Dagfinn</creatorcontrib><creatorcontrib>Riboli, Elio</creatorcontrib><creatorcontrib>Cross, Amanda J</creatorcontrib><title>Gallstones and incident colorectal cancer in a large pan‐European cohort study</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclear whether gallstones are a risk factor for CRC. We examined the association between history of gallstones and CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a prospective cohort of over half a million participants from ten European countries. History of gallstones was assessed at baseline using a self‐reported questionnaire. The analytic cohort included 334,986 participants; a history of gallstones was reported by 3,917 men and 19,836 women, and incident CRC was diagnosed among 1,832 men and 2,178 women (mean follow‐up: 13.6 years). Hazard ratios (HR) and 95% confidence intervals (CI) for the association between gallstones and CRC were estimated using Cox proportional hazards regression models, stratified by sex, study centre and age at recruitment. The models were adjusted for body mass index, diabetes, alcohol intake and physical activity. A positive, marginally significant association was detected between gallstones and CRC among women in multivariable analyses (HR = 1.14, 95%CI 0.99–1.31, p = 0.077). The relationship between gallstones and CRC among men was inverse but not significant (HR = 0.81, 95%CI 0.63–1.04, p = 0.10). Additional adjustment for details of reproductive history or waist circumference yielded minimal changes to the observed associations. Further research is required to confirm the nature of the association between gallstones and CRC by sex.
What's new?
Gallstones can be extremely painful. But might the inflammation they cause also increase the risk of colorectal cancer (CRC)? Previous results have been inconsistent. In this large, prospective study, the authors found a slight positive association between gallstones and CRC among women. For men, on the other hand, there was an inverse association, but the data didn't reach statistical significance. More research is needed to confirm and further explore these sex‐based differences.</description><subject>Adult</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Calculi</subject><subject>Cancer</subject><subject>cohort</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - complications</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Complications</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>EPIC</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Gallstones</subject><subject>Gallstones - complications</subject><subject>Gallstones - epidemiology</subject><subject>Health risk assessment</subject><subject>Health 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Martin</creatorcontrib><creatorcontrib>Aune, Dagfinn</creatorcontrib><creatorcontrib>Riboli, Elio</creatorcontrib><creatorcontrib>Cross, Amanda J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ward, Heather A</au><au>Murphy, Neil</au><au>Weiderpass, Elisabete</au><au>Leitzmann, Michael F</au><au>Aglago, Elom</au><au>Gunter, Marc J</au><au>Freisling, Heinz</au><au>Jenab, Mazda</au><au>Boutron‐Ruault, Marie‐Christine</au><au>Severi, Gianluca</au><au>Carbonnel, Franck</au><au>Kühn, Tilman</au><au>Kaaks, Rudolf</au><au>Boeing, Heiner</au><au>Tjønneland, Anne</au><au>Olsen, Anja</au><au>Overvad, Kim</au><au>Merino, Susana</au><au>Zamora‐Ros, Raul</au><au>Rodríguez‐Barranco, Miguel</au><au>Dorronsoro, Miren</au><au>Chirlaque, Maria‐Dolores</au><au>Barricarte, Aurelio</au><au>Perez‐Cornago, Aurora</au><au>Trichopoulou, Antonia</au><au>Bamia, Christina</au><au>Lagiou, Pagona</au><au>Masala, Giovanna</au><au>Grioni, Sara</au><au>Tumino, Rosario</au><au>Sacerdote, Carlotta</au><au>Mattiello, Amalia</au><au>Bueno‐de‐Mesquita, Bas</au><au>Vermeulen, Roel</au><au>Van Gils, Carla</au><au>Nyström, Hanna</au><au>Rutegård, Martin</au><au>Aune, Dagfinn</au><au>Riboli, Elio</au><au>Cross, Amanda J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gallstones and incident colorectal cancer in a large pan‐European cohort study</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2019-09-15</date><risdate>2019</risdate><volume>145</volume><issue>6</issue><spage>1510</spage><epage>1516</epage><pages>1510-1516</pages><issn>0020-7136</issn><issn>1097-0215</issn><eissn>1097-0215</eissn><abstract>Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclear whether gallstones are a risk factor for CRC. We examined the association between history of gallstones and CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a prospective cohort of over half a million participants from ten European countries. History of gallstones was assessed at baseline using a self‐reported questionnaire. The analytic cohort included 334,986 participants; a history of gallstones was reported by 3,917 men and 19,836 women, and incident CRC was diagnosed among 1,832 men and 2,178 women (mean follow‐up: 13.6 years). Hazard ratios (HR) and 95% confidence intervals (CI) for the association between gallstones and CRC were estimated using Cox proportional hazards regression models, stratified by sex, study centre and age at recruitment. The models were adjusted for body mass index, diabetes, alcohol intake and physical activity. A positive, marginally significant association was detected between gallstones and CRC among women in multivariable analyses (HR = 1.14, 95%CI 0.99–1.31, p = 0.077). The relationship between gallstones and CRC among men was inverse but not significant (HR = 0.81, 95%CI 0.63–1.04, p = 0.10). Additional adjustment for details of reproductive history or waist circumference yielded minimal changes to the observed associations. Further research is required to confirm the nature of the association between gallstones and CRC by sex.
What's new?
Gallstones can be extremely painful. But might the inflammation they cause also increase the risk of colorectal cancer (CRC)? Previous results have been inconsistent. In this large, prospective study, the authors found a slight positive association between gallstones and CRC among women. For men, on the other hand, there was an inverse association, but the data didn't reach statistical significance. More research is needed to confirm and further explore these sex‐based differences.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30585640</pmid><doi>10.1002/ijc.32090</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8008-5096</orcidid><orcidid>https://orcid.org/0000-0003-3347-8249</orcidid><orcidid>https://orcid.org/0000-0002-6236-6804</orcidid><orcidid>https://orcid.org/0000-0002-2721-2404</orcidid><orcidid>https://orcid.org/0000-0002-3646-8006</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 2019-09, Vol.145 (6), p.1510-1516 |
| issn | 0020-7136 1097-0215 1097-0215 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_483183 |
| source | MEDLINE; Wiley Journals; SWEPUB Freely available online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Alcoholic beverages Alcohols Body mass Body mass index Calculi Cancer cohort Cohort analysis Cohort Studies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - complications Colorectal Neoplasms - epidemiology Complications Diabetes Diabetes mellitus EPIC Europe - epidemiology Female Gallstones Gallstones - complications Gallstones - epidemiology Health risk assessment Health risks Humans Incidence Male Medical research Medicin och hälsovetenskap Middle Aged Physical activity Proportional Hazards Models Registries Regression analysis Risk Factors Smoking |
| title | Gallstones and incident colorectal cancer in a large pan‐European cohort study |
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