Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus‐associated syndromes

Two related hyperinflammatory syndromes are distinguished following infection of humans with hantaviruses: haemorrhagic fever with renal syndrome (HFRS) seen in Eurasia and hantavirus pulmonary syndrome (HPS) seen in the Americas. Fatality rates are high, up to 10% for HFRS and around 35%–40% for HP...

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Veröffentlicht in:	Journal of internal medicine 2019-05, Vol.285 (5), p.510-523
Hauptverfasser:	Klingström, J., Smed‐Sörensen, A., Maleki, K. T., Solà‐Riera, C., Ahlm, C., Björkström, N. K., Ljunggren, H. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Apoptosis Blood CD8 antigen Cell activation Disorders Fever haemorrhagic fever with renal syndrome Hantavirus Hantavirus pulmonary syndrome Hantavirus Pulmonary Syndrome - immunology Hantavirus Pulmonary Syndrome - therapy Hemorrhagic fever with renal syndrome Hemorrhagic Fever with Renal Syndrome - immunology Hemorrhagic Fever with Renal Syndrome - therapy Human behavior Humans Immunity, Innate Immunopathogenesis Infections Inflammation Key Symposium Leukocytes (mononuclear) Lungs Lymphocytes Lymphocytes T Natural killer cells orthohantavirus Pathogenesis Peripheral blood Phagocytes Puumala virus Severity of Illness Index Therapeutic applications viral immunity Viremia Viruses
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