The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress

The combination of ascorbate and menadione (VC:VK3 = 100:1) is an investigational treatment for cancer under clinical trials. Dehydroascorbic acid (DHA), the oxidized form of ascorbate, can be taken up by cells via glucose transporters, over-expressed in many cancer cells. It has been known that the...

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Veröffentlicht in:	Free radical biology & medicine 2019-04, Vol.134, p.350-358
Hauptverfasser:	Ren, Xiaoyuan, Santhosh, Sebastin M., Coppo, Lucia, Ogata, Fernando T., Lu, Jun, Holmgren, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbate Ascorbic Acid - pharmacology Cell Death DNA Replication - drug effects DNA synthesis Drug Combinations Gene Expression Regulation, Neoplastic - drug effects Glutaredoxin Glutaredoxins - genetics Glutaredoxins - metabolism Glutathione Glutathione - metabolism Humans Menadione Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Orphan Nuclear Receptors - genetics Orphan Nuclear Receptors - metabolism Oxidative Stress - drug effects Reactive Oxygen Species - metabolism Thioredoxin Thioredoxins - genetics Thioredoxins - metabolism Tumor Cells, Cultured Vitamin K 3 - pharmacology Vitamins - pharmacology
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