High-Resolution Regulatory Maps Connect Vascular Risk Variants to Disease-Related Pathways

Genetic variant landscape of coronary artery disease is dominated by noncoding variants among which many occur within putative enhancers regulating the expression levels of relevant genes. It is crucial to assign the genetic variants to their correct genes both to gain insights into perturbed functi...

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Veröffentlicht in:	Circulation. Cardiovascular genetics 2019-03, Vol.12 (3), p.e002353-e002353
Hauptverfasser:	Åkerborg, Örjan, Spalinskas, Rapolas, Pradhananga, Sailendra, Anil, Anandashankar, Höjer, Pontus, Poujade, Flore-Anne, Folkersen, Lasse, Eriksson, Per, Sahlén, Pelin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line coronary artery disease Coronary Artery Disease - genetics Coronary Artery Disease - pathology Enhancer Elements, Genetic gene Gene Regulatory Networks Genetic Variation Genome-Wide Association Study Genomics haplotype Haplotypes Humans inflammation Linkage Disequilibrium Medicin och hälsovetenskap Original Polymorphism, Single Nucleotide Promoter Regions, Genetic Risk Factors
Online-Zugang:	Volltext
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