Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study

Imaging biomarkers are needed to detect early brain changes in presymptomatic carriers harbouring FTD mutations. Using arterial spin labelling-MRI, Mutsaerts, Mirza et al. identify an inverse association between cerebral perfusion in frontotemporoparietal regions and expected age of onset. Cerebral...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2019-04, Vol.142 (4), p.1108-1120
Hauptverfasser:	Mutsaerts, Henri J M M, Mirza, Saira S, Petr, Jan, Thomas, David L, Cash, David M, Bocchetta, Martina, de Vita, Enrico, Metcalfe, Arron W S, Shirzadi, Zahra, Robertson, Andrew D, Tartaglia, Maria Carmela, Mitchell, Sara B, Black, Sandra E, Freedman, Morris, Tang-Wai, David, Keren, Ron, Rogaeva, Ekaterina, van Swieten, John, Laforce, Robert, Tagliavini, Fabrizio, Borroni, Barbara, Galimberti, Daniela, Rowe, James B, Graff, Caroline, Frisoni, Giovanni B, Finger, Elizabeth, Sorbi, Sandro, de Mendonça, Alexandre, Rohrer, Jonathan D, MacIntosh, Bradley J, Masellis, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Brain - metabolism C9orf72 Protein - genetics Cerebrovascular Circulation - genetics Cross-Sectional Studies Female Frontotemporal Dementia - genetics Heterozygote Humans Magnetic Resonance Imaging Male Middle Aged Mutation Neuropsychological Tests Original Progranulins - genetics tau Proteins - genetics
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