Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma

ObjectiveCurrent strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC.DesignTranscriptional profiling of 273 formalin...

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Veröffentlicht in:	Gut 2019-11, Vol.68 (11), p.1918-1927
Hauptverfasser:	Turkington, Richard C, Knight, Laura A, Blayney, Jaine K, Secrier, Maria, Douglas, Rosalie, Parkes, Eileen E, Sutton, Eilis K, Stevenson, Leanne, McManus, Damian, Halliday, Sophia, McCavigan, Andrena M, Logan, Gemma E, Walker, Steven M, Steele, Christopher J, Perner, Juliane, Bornschein, Jan, MacRae, Shona, Miremadi, Ahmad, McCarron, Eamon, McQuaid, Stephen, Arthur, Kenneth, James, Jacqueline A, O’Neill, Robert, Noble, Fergus, Underwood, Timothy J, Harkin, D Paul, Salto-Tellez, Manuel, Fitzgerald, Rebecca C, Kennedy, Richard D, Noorani, Ayesha, Edwards, Paul Aw, Grehan, Nicola, Nutzinger, Barbara, Hughes, Caitriona, Fidziukiewicz, Elwira, Crawte, Jason, Northrop, Alex, Contino, Gianmarco, Li, Xiaodun, La rue, Rachel De, O’donovan, Maria, Malhotra, Shalini, Tripathi, Monika, Tavaré, Simon, Lynch, Andy G, Eldridge, Matthew, Bower, Lawrence, Devonshire, Ginny, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J, Ang, Yeng, Preston, Shaun R, Oakes, Sarah, Bagwan, Izhar, Save, Vicki, Skipworth, Richard Je, Hupp, Ted R, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Owsley, Jack, Barr, Hugh, Old, Oliver, Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Zylstra, Janine, Mahadeva, Ula, Goh, Vicky, Ciccarelli, Francesca D, Sanders, Grant, Berrisford, Richard, Harden, Catherine, Lewis, Mike, Cheong, Ed, Kumar, Bhaskar, Parsons, Simon L, Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Igali, Laszlo, Scott, Michael, Sothi, Sharmila, Suortamo, Sari, Lishman, Suzy, Hanna, George B, Moorthy, Krishna, Peters, Christopher J, Grabowska, Anna, Coleman, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - immunology Adenocarcinoma - mortality Adenocarcinoma - therapy Aged Antineoplastic Agents - therapeutic use B7-H1 Antigen Biology Biomarkers Breast cancer Cancer therapies CD8 antigen CD8-Positive T-Lymphocytes Chemotherapy Chemotherapy, Adjuvant Deoxyribonucleic acid Disease-Free Survival DNA DNA damage DNA Damage - immunology DNA repair Endoscopy Esophageal cancer Esophageal Neoplasms - immunology Esophageal Neoplasms - mortality Esophageal Neoplasms - therapy Esophagectomy Esophagus Female Gene expression Humans Immune response Immunotherapy Inflammation Ligands Lymphocytes Male Medical prognosis Medical research Melanoma Middle Aged Multivariate analysis Mutation Neoadjuvant Therapy oesophageal cancer Oesophagus Ovarian cancer Paraffin Patients PD-L1 protein Platinum Predictive Value of Tests Response rates Studies Surgery Survival Rate Transcription Treatment Outcome Tumors
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