Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma

Gastro-oesophageal reflux disease (GORD) has long been associated with poor asthma control without an established cause-effect relationship. 610 asthmatics (421 severe/88 mild-moderate) and 101 healthy controls were assessed clinically and a subset of 154 severe asthmatics underwent proteomic analys...

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Veröffentlicht in:	Respiratory medicine 2019-04, Vol.150, p.66-73
Hauptverfasser:	Tariq, K., Schofield, J.P.R., Nicholas, B.L., Burg, D., Brandsma, J., Bansal, A.T., Wilson, S.J., Lutter, R., Fowler, S.J., Bakke, Caruso, M., Dahlen, B., Horváth, I., Krug, N., Montuschi, P., Sanak, M., Sandström, T., Geiser, T., Pandis, I., Sousa, A.R., Adcock, I.M., Shaw, D.E., Auffray, C., Howarth, P.H., Sterk, P.J., Chung, K.F., Skipp, P.J., Dimitrov, B., Djukanović, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiinfectives and antibacterials Anxiety Asthma Asthma - complications Asthma - epidemiology Asthma - metabolism Asthma - psychology Biomarkers Cause-effect relationships Complement component C1 Corticosteroids Disease control Endopeptidases - metabolism Esophagus European Union - organization & administration Female Gastroesophageal reflux Gastroesophageal Reflux - complications Gastroesophageal Reflux - diagnosis Gastroesophageal Reflux - epidemiology Humans Immunoglobulin lambda-Chains - metabolism Immunoglobulins Keratin Lipocalin Lipocalin 1 - metabolism Male Mass spectrometry Mass spectroscopy Mental depression Microorganisms Middle Aged Patients Phenotypes Prevalence Prospective Studies Protease Inhibitors - metabolism Proteinase inhibitors Proteins Proteomics - methods Quality of Life Questionnaires Regression analysis Respiratory diseases Scientific imaging Severity of Illness Index Signs and symptoms Sputum Sputum - metabolism
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