No increased risk of short-term complications after radical cystectomy for muscle-invasive bladder cancer among patients treated with preoperative chemotherapy: a nation-wide register-based study
Purpose Preoperative chemotherapy is underused in conjunction with radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) due to concerns for complications and delay of surgery. Prospective data on short-term complications from population-based settings with frequent use of preoperative c...
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| Veröffentlicht in: | World journal of urology 2020, Vol.38 (2), p.381-388 |
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| creator | Jerlström, Tomas Chen, Ruoqing Liedberg, Fredrik Andrén, Ove Ströck, Viveka Aljabery, Firas A. S. Hosseini, Abolfazl Sherif, Amir Malmström, Per-Uno Ullén, Anders Gårdmark, Truls Fall, Katja |
| description | Purpose
Preoperative chemotherapy is underused in conjunction with radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) due to concerns for complications and delay of surgery. Prospective data on short-term complications from population-based settings with frequent use of preoperative chemotherapy and standardised reporting of complications is lacking.
Methods
We identified 1,340 patients who underwent RC between 2011 and 2015 in Sweden due to MIBC according to the Swedish Cystectomy Register. These individuals were followed through linkages to several national registers. Propensity score adjusted logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for complications and death within 90 days of surgery, comparing patients receiving preoperative chemotherapy or not.
Results
Minimum two cycles of preoperative chemotherapy were given to 519 (39%) of the patients, who on average tended to be younger, have higher education, better physical status, and more advanced bladder cancer than patients not receiving chemotherapy. After adjusting for these and other parameters, there was no association between treatment with preoperative chemotherapy and short-term complications (OR 1.06 95% CI 0.82–1.39) or mortality (OR 0.75 95% CI 0.36–1.55). We observed a risk reduction for gastrointestinal complications among patients who received preoperative chemotherapy compared with those who did not (OR 0.49 95% CI 0.30–0.81).
Conclusion
This nation-wide population-based observational study does not suggest that preoperative chemotherapy, in a setting with high utilisation of such treatment, is associated with an increased risk of short-term complications in MIBC patients treated with radical cystectomy. |
| doi_str_mv | 10.1007/s00345-019-02770-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_480262</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2213652581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c769t-268365faa7a111314eaa564a23e98ecca630585af7a7c1bd7aef3d57dcc6c38c3</originalsourceid><addsrcrecordid>eNqNk8tu1TAQhiMEoqXwAiyQJTYsCPiWOGGBVJWrVMEG2FpznMk5Lkkc7KTVeT5ejDkXWorUqgvLycw3_29bM1n2VPBXgnPzOnGudJFzUedcGsNzeS87FFqpvDKyvJ8dciN1rutKHWSPUjrjXJiSFw-zAyW45Frqw-z3l8D84CJCwoZFn36y0LK0CnHKJ4w9c6EfO-9g8mFIDFoKsggNRTrm1mlCN4V-zdoQWT8n12Huh3NI_hzZooOmIdzB4GiDPgxLNpISDlNiE3lO5HnhpxUbI4YRI-Wozq2wD9OKfsf1GwZs2JrnF75BFnHpyTTmi-2B0zQ368fZgxa6hE_2-1H2_cP7byef8tOvHz-fHJ_mzpT1lMuyUmXRAhgQQiihEaAoNUiFdYXOQal4URXQGjBOLBoD2KqmMI1zpVOVU0dZvtNNFzjOCztG30Nc2wDe7kM_6QutrrgsJfGnN_LdPNJa0NoUOF4rBKwsgqisFogWzKKxLYh64WpVtLy51X5JchRabtVkpatKEP_yRv6d_3FsQ1zaebZacS7VrfJXeD9bUZD-HeVDnK1RNb38neQ7T_KlqkxB_NsdT3CPjaOeidBdK7ueGfzKLsO5Letaa2lI4MVeIIZfM6bJ9j457DoYMMzJSikKLnRRloQ-_w89C3McqJc2FDWNLLYXljvKxZBSxPbyMILbzUDa3UBaGki7HUi76YFn_17jsuTvBBKg9u9CqWGJ8cr7Ftk_QDJKtQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2213652581</pqid></control><display><type>article</type><title>No increased risk of short-term complications after radical cystectomy for muscle-invasive bladder cancer among patients treated with preoperative chemotherapy: a nation-wide register-based study</title><source>MEDLINE</source><source>SWEPUB Freely available online</source><source>SpringerLink Journals - AutoHoldings</source><creator>Jerlström, Tomas ; Chen, Ruoqing ; Liedberg, Fredrik ; Andrén, Ove ; Ströck, Viveka ; Aljabery, Firas A. S. ; Hosseini, Abolfazl ; Sherif, Amir ; Malmström, Per-Uno ; Ullén, Anders ; Gårdmark, Truls ; Fall, Katja</creator><creatorcontrib>Jerlström, Tomas ; Chen, Ruoqing ; Liedberg, Fredrik ; Andrén, Ove ; Ströck, Viveka ; Aljabery, Firas A. S. ; Hosseini, Abolfazl ; Sherif, Amir ; Malmström, Per-Uno ; Ullén, Anders ; Gårdmark, Truls ; Fall, Katja</creatorcontrib><description>Purpose
Preoperative chemotherapy is underused in conjunction with radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) due to concerns for complications and delay of surgery. Prospective data on short-term complications from population-based settings with frequent use of preoperative chemotherapy and standardised reporting of complications is lacking.
Methods
We identified 1,340 patients who underwent RC between 2011 and 2015 in Sweden due to MIBC according to the Swedish Cystectomy Register. These individuals were followed through linkages to several national registers. Propensity score adjusted logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for complications and death within 90 days of surgery, comparing patients receiving preoperative chemotherapy or not.
Results
Minimum two cycles of preoperative chemotherapy were given to 519 (39%) of the patients, who on average tended to be younger, have higher education, better physical status, and more advanced bladder cancer than patients not receiving chemotherapy. After adjusting for these and other parameters, there was no association between treatment with preoperative chemotherapy and short-term complications (OR 1.06 95% CI 0.82–1.39) or mortality (OR 0.75 95% CI 0.36–1.55). We observed a risk reduction for gastrointestinal complications among patients who received preoperative chemotherapy compared with those who did not (OR 0.49 95% CI 0.30–0.81).
Conclusion
This nation-wide population-based observational study does not suggest that preoperative chemotherapy, in a setting with high utilisation of such treatment, is associated with an increased risk of short-term complications in MIBC patients treated with radical cystectomy.</description><identifier>ISSN: 0724-4983</identifier><identifier>ISSN: 1433-8726</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-019-02770-2</identifier><identifier>PMID: 31020424</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Antineoplastic Agents - therapeutic use ; Biopsy ; Bladder cancer ; Cancer ; Cancer and Oncology ; Cancer och onkologi ; Chemotherapy ; Clinical Medicine ; Cystectomy - adverse effects ; Education ; Female ; Follow-Up Studies ; Humans ; Incidence ; Induction chemotherapy ; Invasiveness ; Kirurgi ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Medicine ; Medicine & Public Health ; Neoadjuvant chemotherapy ; Neoplasm Invasiveness ; Nephrology ; Njurmedicin ; Oncology ; Original ; Original Article ; Patients ; Population studies ; Population Surveillance - methods ; Postoperative complications ; Postoperative Complications - epidemiology ; Preoperative Care - methods ; Prognosis ; Radical cystectomy ; Registries ; Retrospective Studies ; Risk Factors ; Short term ; Surgery ; Sweden - epidemiology ; Time Factors ; Urinary Bladder Neoplasms - diagnosis ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - surgery ; Urologi och njurmedicin ; Urology ; Urology and Nephrology</subject><ispartof>World journal of urology, 2020, Vol.38 (2), p.381-388</ispartof><rights>The Author(s) 2019</rights><rights>World Journal of Urology is a copyright of Springer, (2019). All Rights Reserved. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c769t-268365faa7a111314eaa564a23e98ecca630585af7a7c1bd7aef3d57dcc6c38c3</citedby><cites>FETCH-LOGICAL-c769t-268365faa7a111314eaa564a23e98ecca630585af7a7c1bd7aef3d57dcc6c38c3</cites><orcidid>0000-0003-4615-5238</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-019-02770-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-019-02770-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,4010,27900,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31020424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-163875$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73968$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158481$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430023$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/284881$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/c093eae8-ea18-41ee-a7bd-fa19bc935f0d$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:142906106$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Jerlström, Tomas</creatorcontrib><creatorcontrib>Chen, Ruoqing</creatorcontrib><creatorcontrib>Liedberg, Fredrik</creatorcontrib><creatorcontrib>Andrén, Ove</creatorcontrib><creatorcontrib>Ströck, Viveka</creatorcontrib><creatorcontrib>Aljabery, Firas A. S.</creatorcontrib><creatorcontrib>Hosseini, Abolfazl</creatorcontrib><creatorcontrib>Sherif, Amir</creatorcontrib><creatorcontrib>Malmström, Per-Uno</creatorcontrib><creatorcontrib>Ullén, Anders</creatorcontrib><creatorcontrib>Gårdmark, Truls</creatorcontrib><creatorcontrib>Fall, Katja</creatorcontrib><title>No increased risk of short-term complications after radical cystectomy for muscle-invasive bladder cancer among patients treated with preoperative chemotherapy: a nation-wide register-based study</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose
Preoperative chemotherapy is underused in conjunction with radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) due to concerns for complications and delay of surgery. Prospective data on short-term complications from population-based settings with frequent use of preoperative chemotherapy and standardised reporting of complications is lacking.
Methods
We identified 1,340 patients who underwent RC between 2011 and 2015 in Sweden due to MIBC according to the Swedish Cystectomy Register. These individuals were followed through linkages to several national registers. Propensity score adjusted logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for complications and death within 90 days of surgery, comparing patients receiving preoperative chemotherapy or not.
Results
Minimum two cycles of preoperative chemotherapy were given to 519 (39%) of the patients, who on average tended to be younger, have higher education, better physical status, and more advanced bladder cancer than patients not receiving chemotherapy. After adjusting for these and other parameters, there was no association between treatment with preoperative chemotherapy and short-term complications (OR 1.06 95% CI 0.82–1.39) or mortality (OR 0.75 95% CI 0.36–1.55). We observed a risk reduction for gastrointestinal complications among patients who received preoperative chemotherapy compared with those who did not (OR 0.49 95% CI 0.30–0.81).
Conclusion
This nation-wide population-based observational study does not suggest that preoperative chemotherapy, in a setting with high utilisation of such treatment, is associated with an increased risk of short-term complications in MIBC patients treated with radical cystectomy.</description><subject>Aged</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biopsy</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Cancer and Oncology</subject><subject>Cancer och onkologi</subject><subject>Chemotherapy</subject><subject>Clinical Medicine</subject><subject>Cystectomy - adverse effects</subject><subject>Education</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Induction chemotherapy</subject><subject>Invasiveness</subject><subject>Kirurgi</subject><subject>Klinisk medicin</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoadjuvant chemotherapy</subject><subject>Neoplasm Invasiveness</subject><subject>Nephrology</subject><subject>Njurmedicin</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Population studies</subject><subject>Population Surveillance - methods</subject><subject>Postoperative complications</subject><subject>Postoperative Complications - epidemiology</subject><subject>Preoperative Care - methods</subject><subject>Prognosis</subject><subject>Radical cystectomy</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Short term</subject><subject>Surgery</subject><subject>Sweden - epidemiology</subject><subject>Time Factors</subject><subject>Urinary Bladder Neoplasms - diagnosis</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Urinary Bladder Neoplasms - surgery</subject><subject>Urologi och njurmedicin</subject><subject>Urology</subject><subject>Urology and Nephrology</subject><issn>0724-4983</issn><issn>1433-8726</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNqNk8tu1TAQhiMEoqXwAiyQJTYsCPiWOGGBVJWrVMEG2FpznMk5Lkkc7KTVeT5ejDkXWorUqgvLycw3_29bM1n2VPBXgnPzOnGudJFzUedcGsNzeS87FFqpvDKyvJ8dciN1rutKHWSPUjrjXJiSFw-zAyW45Frqw-z3l8D84CJCwoZFn36y0LK0CnHKJ4w9c6EfO-9g8mFIDFoKsggNRTrm1mlCN4V-zdoQWT8n12Huh3NI_hzZooOmIdzB4GiDPgxLNpISDlNiE3lO5HnhpxUbI4YRI-Wozq2wD9OKfsf1GwZs2JrnF75BFnHpyTTmi-2B0zQ368fZgxa6hE_2-1H2_cP7byef8tOvHz-fHJ_mzpT1lMuyUmXRAhgQQiihEaAoNUiFdYXOQal4URXQGjBOLBoD2KqmMI1zpVOVU0dZvtNNFzjOCztG30Nc2wDe7kM_6QutrrgsJfGnN_LdPNJa0NoUOF4rBKwsgqisFogWzKKxLYh64WpVtLy51X5JchRabtVkpatKEP_yRv6d_3FsQ1zaebZacS7VrfJXeD9bUZD-HeVDnK1RNb38neQ7T_KlqkxB_NsdT3CPjaOeidBdK7ueGfzKLsO5Letaa2lI4MVeIIZfM6bJ9j457DoYMMzJSikKLnRRloQ-_w89C3McqJc2FDWNLLYXljvKxZBSxPbyMILbzUDa3UBaGki7HUi76YFn_17jsuTvBBKg9u9CqWGJ8cr7Ftk_QDJKtQ</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Jerlström, Tomas</creator><creator>Chen, Ruoqing</creator><creator>Liedberg, Fredrik</creator><creator>Andrén, Ove</creator><creator>Ströck, Viveka</creator><creator>Aljabery, Firas A. S.</creator><creator>Hosseini, Abolfazl</creator><creator>Sherif, Amir</creator><creator>Malmström, Per-Uno</creator><creator>Ullén, Anders</creator><creator>Gårdmark, Truls</creator><creator>Fall, Katja</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG8</scope><scope>AABEP</scope><scope>D8T</scope><scope>D91</scope><scope>ZZAVC</scope><scope>ADHXS</scope><scope>D93</scope><scope>ACNBI</scope><scope>DF2</scope><scope>F1U</scope><scope>AGCHP</scope><scope>D95</scope><orcidid>https://orcid.org/0000-0003-4615-5238</orcidid></search><sort><creationdate>2020</creationdate><title>No increased risk of short-term complications after radical cystectomy for muscle-invasive bladder cancer among patients treated with preoperative chemotherapy: a nation-wide register-based study</title><author>Jerlström, Tomas ; Chen, Ruoqing ; Liedberg, Fredrik ; Andrén, Ove ; Ströck, Viveka ; Aljabery, Firas A. S. ; Hosseini, Abolfazl ; Sherif, Amir ; Malmström, Per-Uno ; Ullén, Anders ; Gårdmark, Truls ; Fall, Katja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c769t-268365faa7a111314eaa564a23e98ecca630585af7a7c1bd7aef3d57dcc6c38c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biopsy</topic><topic>Bladder cancer</topic><topic>Cancer</topic><topic>Cancer and Oncology</topic><topic>Cancer och onkologi</topic><topic>Chemotherapy</topic><topic>Clinical Medicine</topic><topic>Cystectomy - adverse effects</topic><topic>Education</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Induction chemotherapy</topic><topic>Invasiveness</topic><topic>Kirurgi</topic><topic>Klinisk medicin</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoadjuvant chemotherapy</topic><topic>Neoplasm Invasiveness</topic><topic>Nephrology</topic><topic>Njurmedicin</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Population studies</topic><topic>Population Surveillance - methods</topic><topic>Postoperative complications</topic><topic>Postoperative Complications - epidemiology</topic><topic>Preoperative Care - methods</topic><topic>Prognosis</topic><topic>Radical cystectomy</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Short term</topic><topic>Surgery</topic><topic>Sweden - epidemiology</topic><topic>Time Factors</topic><topic>Urinary Bladder Neoplasms - diagnosis</topic><topic>Urinary Bladder Neoplasms - drug therapy</topic><topic>Urinary Bladder Neoplasms - surgery</topic><topic>Urologi och njurmedicin</topic><topic>Urology</topic><topic>Urology and Nephrology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jerlström, Tomas</creatorcontrib><creatorcontrib>Chen, Ruoqing</creatorcontrib><creatorcontrib>Liedberg, Fredrik</creatorcontrib><creatorcontrib>Andrén, Ove</creatorcontrib><creatorcontrib>Ströck, Viveka</creatorcontrib><creatorcontrib>Aljabery, Firas A. S.</creatorcontrib><creatorcontrib>Hosseini, Abolfazl</creatorcontrib><creatorcontrib>Sherif, Amir</creatorcontrib><creatorcontrib>Malmström, Per-Uno</creatorcontrib><creatorcontrib>Ullén, Anders</creatorcontrib><creatorcontrib>Gårdmark, Truls</creatorcontrib><creatorcontrib>Fall, Katja</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Linköpings universitet</collection><collection>SWEPUB Örebro universitet full text</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Örebro universitet</collection><collection>SwePub Articles full text</collection><collection>SWEPUB Umeå universitet full text</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SWEPUB Lunds universitet</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jerlström, Tomas</au><au>Chen, Ruoqing</au><au>Liedberg, Fredrik</au><au>Andrén, Ove</au><au>Ströck, Viveka</au><au>Aljabery, Firas A. S.</au><au>Hosseini, Abolfazl</au><au>Sherif, Amir</au><au>Malmström, Per-Uno</au><au>Ullén, Anders</au><au>Gårdmark, Truls</au><au>Fall, Katja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No increased risk of short-term complications after radical cystectomy for muscle-invasive bladder cancer among patients treated with preoperative chemotherapy: a nation-wide register-based study</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2020</date><risdate>2020</risdate><volume>38</volume><issue>2</issue><spage>381</spage><epage>388</epage><pages>381-388</pages><issn>0724-4983</issn><issn>1433-8726</issn><eissn>1433-8726</eissn><abstract>Purpose
Preoperative chemotherapy is underused in conjunction with radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) due to concerns for complications and delay of surgery. Prospective data on short-term complications from population-based settings with frequent use of preoperative chemotherapy and standardised reporting of complications is lacking.
Methods
We identified 1,340 patients who underwent RC between 2011 and 2015 in Sweden due to MIBC according to the Swedish Cystectomy Register. These individuals were followed through linkages to several national registers. Propensity score adjusted logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for complications and death within 90 days of surgery, comparing patients receiving preoperative chemotherapy or not.
Results
Minimum two cycles of preoperative chemotherapy were given to 519 (39%) of the patients, who on average tended to be younger, have higher education, better physical status, and more advanced bladder cancer than patients not receiving chemotherapy. After adjusting for these and other parameters, there was no association between treatment with preoperative chemotherapy and short-term complications (OR 1.06 95% CI 0.82–1.39) or mortality (OR 0.75 95% CI 0.36–1.55). We observed a risk reduction for gastrointestinal complications among patients who received preoperative chemotherapy compared with those who did not (OR 0.49 95% CI 0.30–0.81).
Conclusion
This nation-wide population-based observational study does not suggest that preoperative chemotherapy, in a setting with high utilisation of such treatment, is associated with an increased risk of short-term complications in MIBC patients treated with radical cystectomy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31020424</pmid><doi>10.1007/s00345-019-02770-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4615-5238</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_swepub_primary_oai_swepub_ki_se_480262 |
| source | MEDLINE; SWEPUB Freely available online; SpringerLink Journals - AutoHoldings |
| subjects | Aged Antineoplastic Agents - therapeutic use Biopsy Bladder cancer Cancer Cancer and Oncology Cancer och onkologi Chemotherapy Clinical Medicine Cystectomy - adverse effects Education Female Follow-Up Studies Humans Incidence Induction chemotherapy Invasiveness Kirurgi Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicine & Public Health Neoadjuvant chemotherapy Neoplasm Invasiveness Nephrology Njurmedicin Oncology Original Original Article Patients Population studies Population Surveillance - methods Postoperative complications Postoperative Complications - epidemiology Preoperative Care - methods Prognosis Radical cystectomy Registries Retrospective Studies Risk Factors Short term Surgery Sweden - epidemiology Time Factors Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - surgery Urologi och njurmedicin Urology Urology and Nephrology |
| title | No increased risk of short-term complications after radical cystectomy for muscle-invasive bladder cancer among patients treated with preoperative chemotherapy: a nation-wide register-based study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T20%3A30%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=No%20increased%20risk%20of%20short-term%20complications%20after%20radical%20cystectomy%20for%20muscle-invasive%20bladder%20cancer%20among%20patients%20treated%20with%20preoperative%20chemotherapy:%20a%20nation-wide%20register-based%20study&rft.jtitle=World%20journal%20of%20urology&rft.au=Jerlstr%C3%B6m,%20Tomas&rft.date=2020&rft.volume=38&rft.issue=2&rft.spage=381&rft.epage=388&rft.pages=381-388&rft.issn=0724-4983&rft.eissn=1433-8726&rft_id=info:doi/10.1007/s00345-019-02770-2&rft_dat=%3Cproquest_swepu%3E2213652581%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2213652581&rft_id=info:pmid/31020424&rfr_iscdi=true |