Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

The hallmarks of Alzheimer's disease (AD) are the accumulation of Aβ plaques and neurofibrillary tangles composed of hyperphosphorylated tau. We developed sensitive cellular assays using human embryonic kidney-293T cells to quantify intracellular self-propagating conformers of Aβ in brain sampl...

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Veröffentlicht in:	Science translational medicine 2019-05, Vol.11 (490), p.1
Hauptverfasser:	Aoyagi, Atsushi, Condello, Carlo, Stöhr, Jan, Yue, Weizhou, Rivera, Brianna M, Lee, Joanne C, Woerman, Amanda L, Halliday, Glenda, van Duinen, Sjoerd, Ingelsson, Martin, Lannfelt, Lars, Graff, Caroline, Bird, Thomas D, Keene, C Dirk, Seeley, William W, DeGrado, William F, Prusiner, Stanley B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Autopsy Drug development Longevity Neurodegenerative diseases Neurofibrillary tangles Senile plaques Tau protein
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