Control of antiviral innate immune response by protein geranylgeranylation

The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection. However, how MAVS signaling is controlled to eradicate virus while preventing self-destructive inflammation remains obscure. Here, we show that protein geranylgeranylation,...

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Veröffentlicht in:	Science advances 2019-05, Vol.5 (5), p.eaav7999-eaav7999
Hauptverfasser:	Yang, Shigao, Harding, Alfred T, Sweeney, Catherine, Miao, David, Swan, Gregory, Zhou, Connie, Jiang, Zhaozhao, Fitzgerald, Katherine A, Hammer, Gianna, Bergo, Martin O, Kroh, Heather K, Lacy, D Borden, Sun, Chunxiang, Glogauer, Michael, Que, Loretta G, Heaton, Nicholas S, Wang, Donghai
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Alkyl and Aryl Transferases - genetics Alkyl and Aryl Transferases - metabolism Animals Endoplasmic Reticulum - immunology Endoplasmic Reticulum - metabolism Female Humans Immunity, Innate - physiology Immunology Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Male Mice, Knockout Neuropeptides - genetics Neuropeptides - metabolism Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - metabolism Orthomyxoviridae Infections - mortality Protein Prenylation - immunology rac GTP-Binding Proteins - genetics rac GTP-Binding Proteins - metabolism rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism RAC2 GTP-Binding Protein Receptor-Interacting Protein Serine-Threonine Kinases - metabolism SciAdv r-articles Tripartite Motif Proteins - metabolism Ubiquitin-Protein Ligases - metabolism
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