A catalog of genetic loci associated with kidney function from analyses of a million individuals

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication ( n = 1,046,070), we identified 264 associated...

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Veröffentlicht in:	Nature genetics 2019-06, Vol.51 (6), p.957-972
Hauptverfasser:	Wuttke, Matthias, Tin, Adrienne, Chai, Jin-Fang, Tayo, Bamidele O., Fuchsberger, Christian, Xu, Yizhe, Yu, Zhi, Akiyama, Masato, Ahluwalia, Tarunveer S., Amin, Najaf, Boissel, Mathilde, Boutin, Thibaud S., Brenner, Hermann, Campbell, Archie, Cusi, Daniele, Daw, E. Warwick, de Borst, Martin H., Delgado, Graciela, Dorajoo, Rajkumar, Elliott, Paul, Endlich, Karlhans, Franco, Oscar H., Franke, Andre, Freitag-Wolf, Sandra, Froguel, Philippe, Gaziano, J. Michael, Gieger, Christian, Gögele, Martin, Gudbjartsson, Daniel F., Gudnason, Vilmundur, Haller, Toomas, Hicks, Andrew A., Hofer, Edith, Ingelsson, Erik, Jaddoe, Vincent W. V., Jakobsdottir, Johanna, Jonas, Jost B., Joshi, Peter K., Jung, Bettina, Kerr, Shona M., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Krajcoviechova, Alena, Krämer, Bernhard K., Kuokkanen, Mikko, Langefeld, Carl D., Lieb, Wolfgang, Lim, Su-Chi, Loos, Ruth J. F., Lucae, Susanne, Martins, Jade, Matsuda, Koichi, Milaneschi, Yuri, Miliku, Kozeta, Montgomery, Grant W., Nolte, Ilja M., Noordam, Raymond, Orho-Melander, Marju, Palsson, Runolfur, Perola, Markus, Pirastu, Mario, Podgornaia, Anna I., Ponte, Belen, Pramstaller, Peter P., Prins, Bram P., Raffield, Laura M., Ridker, Paul M., Roberts, David J., Rudan, Igor, Saba, Yasaman, Saum, Kai-Uwe, Schöttker, Ben, Smith, Albert V., Smith, Blair H., Taylor, Kent D., Thomsen, Hauke, Toniolo, Daniela, Tönjes, Anke, van Dam, Rob M., Verweij, Niek, Völker, Uwe, Wallentin, Lars, Waterworth, Dawn M., White, Harvey, Wild, Sarah H., Wilson, James F., Yerges-Armstrong, Laura M., Bochud, Murielle, Wilson, James G., Parsa, Afshin, Chasman, Daniel I., Pendergrass, Sarah A., Sim, Xueling, Böger, Carsten A., Okada, Yukinori, Hung, Adriana M., Scholz, Markus, Köttgen, Anna, Pattaro, Cristian
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 631/208 631/208/205 631/208/205/2138 631/208/457 Agriculture Analysis Animal Genetics and Genomics Animal models Basic Medicine Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Research Cardiovascular disease Chromosome Mapping Chronic kidney failure Diagnosis Epidermal growth factor receptors Gene expression Gene Function Gene loci Gene mapping Genes Genetic aspects Genetic Association Studies - methods Genetic markers Genetic Predisposition to Disease Genetics Genome-wide association studies Genome-Wide Association Study Genomes Glomerular Filtration Rate Health and Welfare Human Genetics Human tissues Humans Hälsa och välfärd Identification and classification Inheritance Patterns Kidney diseases Kidney Function Tests Kidneys Life Sciences Mapping Medical and Health Sciences Medical Genetics Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Meta-analysis Metabolism Phenotype Phenotypes Polymorphism, Single Nucleotide Population Public health Quantitative Trait Loci Quantitative Trait, Heritable Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - physiopathology Renal Insufficiency, Chronic - urine Studies Urea Uromodulin - urine White People
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