Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

IMPORTANCE: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disor...

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Veröffentlicht in:	Archives of neurology (Chicago) 2019-09, Vol.76 (9), p.1035-1048
Hauptverfasser:	Bridel, Claire, van Wieringen, Wessel N, Zetterberg, Henrik, Tijms, Betty M, Teunissen, Charlotte E, Alvarez-Cermeño, José C, Andreasson, Ulf, Axelsson, Markus, Bäckström, David C, Bartos, Ales, Bjerke, Maria, Blennow, Kaj, Boxer, Adam, Brundin, Lou, Burman, Joachim, Christensen, Tove, Fialová, Lenká, Forsgren, Lars, Frederiksen, Jette L, Gisslén, Magnus, Gray, Elizabeth, Gunnarsson, Martin, Hall, Sara, Hansson, Oskar, Herbert, Megan K, Jakobsson, Joel, Jessen-Krut, Jan, Janelidze, Shorena, Johannsson, Gudmundur, Jonsson, Michael, Kappos, Ludwig, Khademi, Mohsen, Khalil, Michael, Kuhle, Jens, Landén, Mikael, Leinonen, Ville, Logroscino, Giancarlo, Lu, Ching-Hua, Lycke, Jan, Magdalinou, Nadia K, Malaspina, Andrea, Mattsson, Niklas, Meeter, Lieke H, Mehta, Sanjay R, Modvig, Signe, Olsson, Tomas, Paterson, Ross W, Pérez-Santiago, Josué, Piehl, Fredrik, Pijnenburg, Yolande A. L, Pyykkö, Okko T, Ragnarsson, Oskar, Rojas, Julio C, Romme Christensen, Jeppe, Sandberg, Linda, Scherling, Carole S, Schott, Jonathan M, Sellebjerg, Finn T, Simone, Isabella L, Skillbäck, Tobias, Stilund, Morten, Sundström, Peter, Svenningsson, Anders, Tortelli, Rosanna, Tortorella, Carla, Trentini, Alessandro, Troiano, Maria, Turner, Martin R, van Swieten, John C, Vågberg, Mattias, Verbeek, Marcel M, Villar, Luisa M, Visser, Pieter Jelle, Wallin, Anders, Weiss, Andreas, Wikkelsø, Carsten, Wild, Edward J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age factors Alzheimer's disease Amyotrophic lateral sclerosis Biomarkers Central nervous system Cerebrospinal fluid Dementia Dementia disorders Diagnosis Diagnostic systems Disorders Frontotemporal dementia HIV Human immunodeficiency virus Immunoassay Inflammatory diseases Levels Medical diagnosis Men Meta-analysis Movement disorders Multiple sclerosis Neurodegenerative diseases Neurological diseases Neurology Online First Original Investigation Parkinson's disease Proteins Psychiatry Psykiatri Sex Sexually transmitted diseases STD Systematic review
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