Heparinoid sevuparin inhibits Streptococcus‐induced vascular leak through neutralizing neutrophil‐derived proteins

ABSTRACTAcute lung injury (ALI) and respiratory distress can develop as a consequence of sepsis with pathogens such as group A Streptococcus (GAS). In the pathogenesis of sepsis‐associated ALI, endothelial barrier disruption brought on by phagocyte activation is considered a causative factor. Here,...

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Veröffentlicht in:	The FASEB journal 2019-09, Vol.33 (9), p.10443-10452
Hauptverfasser:	Rasmuson, Joel, Kenne, Ellinor, Wahlgren, Mats, Soehnlein, Oliver, Lindbom, Lennart
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology heparin Heparin - analogs & derivatives Heparin - pharmacology Histones - metabolism Humans inflammation Lipopolysaccharides - toxicity Male Medicin och hälsovetenskap Mice Mice, Inbred BALB C Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology Pneumonia - etiology Pneumonia - metabolism Pneumonia - pathology Pneumonia - prevention & control S100 Proteins - metabolism sepsis Sepsis - complications Sepsis - microbiology Serine Proteases - metabolism Streptococcal Infections - complications Streptococcal Infections - microbiology Streptococcus - pathogenicity vascular permeability
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