Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c‑MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA

The c-MYC transcription factor is a master regulator of cell growth and proliferation and is an established target for cancer therapy. This basic helix–loop–helix Zip protein forms a heterodimer with its obligatory partner MAX, which binds to DNA via the basic region. Considerable research efforts a...

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Veröffentlicht in:	Biochemistry (Easton) 2019-07, Vol.58 (29), p.3144-3154
Hauptverfasser:	Sammak, Susan, Hamdani, Najoua, Gorrec, Fabrice, Allen, Mark D, Freund, Stefan M. V, Bycroft, Mark, Zinzalla, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism cell growth Chickens crystal structure Crystallography, X-Ray - methods dimerization disulfides DNA DNA - chemistry DNA - genetics DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Helix-Loop-Helix Motifs - physiology Humans Magnetic Resonance Spectroscopy - methods neoplasms nuclear magnetic resonance spectroscopy Protein Structure, Secondary Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism therapeutics transcription factors Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism X-ray diffraction
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