Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells

While smoking is known to associate with development of multiple diseases, the underlying mechanisms are still poorly understood. Tobacco smoking can modify the chemical integrity of DNA leading to changes in transcriptional activity, partly through an altered epigenetic state. We aimed to investiga...

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Veröffentlicht in:EBioMedicine 2019-08, Vol.46, p.290-304
Hauptverfasser: Ringh, Mikael V., Hagemann-Jensen, Michael, Needhamsen, Maria, Kular, Lara, Breeze, Charles E., Sjöholm, Louise K., Slavec, Lara, Kullberg, Susanna, Wahlström, Jan, Grunewald, Johan, Brynedal, Boel, Liu, Yun, Almgren, Malin, Jagodic, Maja, Öckinger, Johan, Ekström, Tomas J.
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Sprache:eng
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