Runs of homozygosity and testicular cancer risk

Background Testicular germ cell tumour (TGCT) is highly heritable but > 50% of the genetic risk remains unexplained. Epidemiological observation of greater relative risk to brothers of men with TGCT compared to sons has long alluded to recessively acting TGCT genetic susceptibility factors, but t...

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Veröffentlicht in:	Andrology (Oxford) 2019-07, Vol.7 (4), p.555-564
Hauptverfasser:	Loveday, C., Sud, A., Litchfield, K., Levy, M., Holroyd, A., Broderick, P., Kote‐Jarai, Z., Dunning, A. M., Muir, K., Eeles, R., Easton, D. F., Dudakia, D., Pashayan, N., Reid, A., Huddart, R. A., Turnbull, C., Rustin, Gordon, Srihari, Narayanan N, Bertelli, Gianfilippo, Barber, James, Gilby, Ed, White, Jeff, Baybrooke, Jeremy, Leahy, Michael, Welch, Richard, Chakraborti, Prabir, Joffe, Johnathan, Brown, Richard, Faust, Guy, Simmonds, Peter, Stockdale, Andrew, Hrounda, David, Appel, Wiebke, Hong, Anne, Howard, Grahame, Douglas, Fiona, Butt, Mohammad, Kelly, Kay, Mehra, Rakesh, Rogers, Paul, Hatton, Matthew, Hennig, Ivo, Savage, Philip, Seckl, Michael, Gale, Joanna, Clark, Peter, Woby, Steve, Rathmell, Adrian, Lamont, Alan, Sarwar, Naveed, Chowdhury, Simon, Beesley, Sharon, Winkler, Mathius, Hamid, Abdel, Pathak, Sanjeev, Madhavan, Krishnaswamy, Highley, Martin, Money‐Kryle, Julian, Brock, Cathryn, Sreenivasan, Thiagarajan, Dalsgaard Sorensen, Karina, Maehle, Lovise, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Travis, Ruth C, Ann Ingles, Sue, Rosenstein, Barry S, Lu, Yong‐Jie, Giles, Graham G, Kibel, Adam S, Vega, Ana, Kogevinas, Manolis, Park, Jong Y, Stanford, Janet L, Cybulski, Cezary, Nordestgaard, Børge G, Brenner, Hermann, Kim, Jeri, John, Esther M, Teixeira, Manuel R, Neuhausen, Susan L, De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F, Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A, Gago Dominguez, Manuela, Roobol, Monique J, Menegaux, Florence, Khaw, Kay‐Tee, Cannon‐Albrigh, Lisa, Pandha, Hardev, Thibodeau, Stephen N
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer Genetics Genome Genome-Wide Association Study genome‐wide association studies Genotype homozygosity mapping Homozygote Humans Male Neoplasms, Germ Cell and Embryonal - genetics Polymorphism, Single Nucleotide recessive Risk Factors runs of homozygosity Testicular cancer testicular germ cell tumour Testicular Neoplasms - genetics Tumors
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