Exposure of normal and chronic bronchitis-like mucosa models to aerosolized carbon nanoparticles: comparison of pro-inflammatory oxidative stress and tissue injury/repair responses

Carbon nanoparticles (CNP) are generated by incomplete combustion of diesel engines. Several epidemiological studies associated higher susceptibility to particulate matter related adverse respiratory outcomes with preexisting conditions like chronic bronchitis (CB). Therefore, we compared the effect...

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Veröffentlicht in:	Nanotoxicology 2019-11, Vol.13 (10), p.1362-1379
Hauptverfasser:	Ji, Jie, Ganguly, Koustav, Mihai, Xenia, Sun, Jitong, Malmlöf, Maria, Gerde, Per, Upadhyay, Swapna, Palmberg, Lena
Format:	Artikel
Sprache:	eng
Schlagworte:	air-liquid interface model Bronchi - cytology Bronchi - drug effects Bronchi - metabolism Bronchitis Bronchitis, Chronic - chemically induced Bronchitis, Chronic - pathology Carbon Carbon - metabolism Carbon nanoparticles Cells, Cultured chronic bronchitis-like model Diesel engines Epidemiology Epithelial cells Epithelial Cells - drug effects Exposure Gelatinase B Gene Expression Regulation - drug effects Humans Inflammation Injuries Interleukin 13 Interleukin 6 Interleukin-8 - metabolism Internal combustion engines Markers Matrix Metalloproteinase 9 - metabolism Mucosa Mucous Membrane - drug effects Nanoparticles NF-κB protein Oxidative stress Oxidative Stress - drug effects Particulate Matter Repair Respiratory Mucosa - drug effects Tissue inhibitor of metalloproteinase 1 Tissues Transcription Tumor necrosis factor
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