Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abunda...

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Veröffentlicht in:	Alzheimer's & dementia 2019-11, Vol.15 (11), p.1478-1488
Hauptverfasser:	Shi, Liu, Westwood, Sarah, Baird, Alison L., Winchester, Laura, Dobricic, Valerija, Kilpert, Fabian, Hong, Shengjun, Franke, Andre, Hye, Abdul, Ashton, Nicholas J., Morgan, Angharad R., Bos, Isabelle, Vos, Stephanie J.B., Buckley, Noel J., Kate, Mara ten, Scheltens, Philip, Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Engelborghs, Sebastiaan, De Roeck, Ellen E., Sleegers, Kristel, Frisoni, Giovanni B., Blin, Olivier, Richardson, Jill C., Bordet, Régis, Molinuevo, José L., Rami, Lorena, Wallin, Anders, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Johannsen, Peter, Teunissen, Charlotte E., Freund-Levi, Yvonne, Frölich, Lutz, Legido-Quigley, Cristina, Barkhof, Frederik, Blennow, Kaj, Zetterberg, Henrik, Baker, Susan, Morgan, B. Paul, Streffer, Johannes, Visser, Pieter Jelle, Bertram, Lars, Lovestone, Simon, Nevado-Holgado, Alejo J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Alzheimer Disease - genetics Alzheimer Disease - metabolism Amyloid - metabolism Amyloid beta Amyloid β Apolipoprotein E4 - genetics Apolipoprotein E4 - metabolism Biomarkers - blood Brain - metabolism Causal relationship Cognitive science Europe Female Humans Male Middle Aged Neuroscience Neurosciences Neurovetenskaper Plasma proteomics Proteomics Psychiatry Psykiatri Replication SOMAscan assay Tau
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