Shiga toxin signals via ATP and its effect is blocked by purinergic receptor antagonism

Shiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli (EHEC), that cause gastrointestinal infection leading to hemolytic uremic syndrome. The aim of this study was to investigate if Stx signals via ATP and if blockade of purinergic receptors could be protective. Stx in...

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Veröffentlicht in:	Scientific reports 2019-10, Vol.9 (1), p.14362-14362, Article 14362
Hauptverfasser:	Johansson, Karl E., Ståhl, Anne-Lie, Arvidsson, Ida, Loos, Sebastian, Tontanahal, Ashmita, Rebetz, Johan, Chromek, Milan, Kristoffersson, Ann-Charlotte, Johannes, Ludger, Karpman, Diana
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 13/31 13/89 14/34 14/63 631/326/1320 64/60 692/4022/1585/2159/1545 82/1 Adenosine Triphosphate - metabolism Animals Apoptosis ATP Basic Medicine Benzenesulfonates - pharmacology Blood Platelets - microbiology Calcium Calcium influx Caspase Caspase-3 Cell and Molecular Biology Cell- och molekylärbiologi Chemical Sciences E coli Enterohemorrhagic Escherichia coli - drug effects Enterohemorrhagic Escherichia coli - pathogenicity Escherichia coli Infections - drug therapy Escherichia coli Infections - genetics Escherichia coli Infections - microbiology Escherichia coli Infections - pathology Experiments Flow cytometry HeLa Cells Hemolytic uremic syndrome Hemolytic-Uremic Syndrome - drug therapy Hemolytic-Uremic Syndrome - genetics Hemolytic-Uremic Syndrome - microbiology Hemolytic-Uremic Syndrome - pathology Humanities and Social Sciences Humans Life Sciences Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Mice multidisciplinary Plasma Platelets Protein biosynthesis Protein synthesis Purine P2X receptors Purine receptors Purinergic P2X Receptor Antagonists - pharmacology Receptors, Purinergic P2X1 - genetics Retrograde transport Science Science (multidisciplinary) Shiga toxin Shiga Toxin - antagonists & inhibitors Shiga Toxin - genetics Suramin Toxins Virulence Virulence factors
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