Effects of parental mental illness on children's physical health: systematic review and meta-analysis

Children of parents with mental disorder face multiple challenges. To summarise evidence about parental mental disorder and child physical health. We searched seven databases for cohort or case-control studies quantifying associations between parental mental disorders (substance use, psychotic, mood...

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Veröffentlicht in:British journal of psychiatry 2020-07, Vol.217 (1), p.354-363
Hauptverfasser: Pierce, Matthias, Hope, Holly F., Kolade, Adekeye, Gellatly, Judith, Osam, Cemre Su, Perchard, Reena, Kosidou, Kyriaki, Dalman, Christina, Morgan, Vera, Di Prinzio, Patricia, Abel, Kathryn M.
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container_title British journal of psychiatry
container_volume 217
creator Pierce, Matthias
Hope, Holly F.
Kolade, Adekeye
Gellatly, Judith
Osam, Cemre Su
Perchard, Reena
Kosidou, Kyriaki
Dalman, Christina
Morgan, Vera
Di Prinzio, Patricia
Abel, Kathryn M.
description Children of parents with mental disorder face multiple challenges. To summarise evidence about parental mental disorder and child physical health. We searched seven databases for cohort or case-control studies quantifying associations between parental mental disorders (substance use, psychotic, mood, anxiety, obsessive-compulsive, post-traumatic stress and eating) and offspring physical health. Studies were excluded if: they reported perinatal outcomes only (
doi_str_mv 10.1192/bjp.2019.216
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To summarise evidence about parental mental disorder and child physical health. We searched seven databases for cohort or case-control studies quantifying associations between parental mental disorders (substance use, psychotic, mood, anxiety, obsessive-compulsive, post-traumatic stress and eating) and offspring physical health. Studies were excluded if: they reported perinatal outcomes only (&lt;28 days) or outcomes after age 18; they measured outcome prior to exposure; or the sample was drawn from diseased children. A meta-analysis was conducted. The protocol was registered on the PROSPERO database (CRD42017072620). Searches revealed 15 945 non-duplicated studies. Forty-one studies met our inclusion criteria: ten investigated accidents/injuries; eight asthma; three other atopic diseases; ten overweight/obesity; ten studied other illnesses (eight from low-and middle-income countries (LMICs)). Half of the studies investigated maternal perinatal mental health, 17% investigated paternal mental disorder and 87% examined maternal depression. Meta-analysis revealed significantly higher rates of injuries (OR = 1.15, 95% CI 1.04-1.26), asthma (OR = 1.26, 95% CI 1.12-1.41) and outcomes recorded in LMICs (malnutrition: OR = 2.55, 95% CI 1.74-3.73; diarrhoea: OR = 2.16, 95% CI 1.65-2.84). Evidence was inconclusive for obesity and other atopic disorders. Children of parents with mental disorder have health disadvantages; however, the evidence base is limited to risks for offspring following postnatal depression in mothers and there is little focus on fathers in the literature. Understanding the physical health risks of these vulnerable children is vital to improving lives. Future work should focus on discovering mechanisms linking physical and mental health across generations. 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To summarise evidence about parental mental disorder and child physical health. We searched seven databases for cohort or case-control studies quantifying associations between parental mental disorders (substance use, psychotic, mood, anxiety, obsessive-compulsive, post-traumatic stress and eating) and offspring physical health. Studies were excluded if: they reported perinatal outcomes only (&lt;28 days) or outcomes after age 18; they measured outcome prior to exposure; or the sample was drawn from diseased children. A meta-analysis was conducted. The protocol was registered on the PROSPERO database (CRD42017072620). Searches revealed 15 945 non-duplicated studies. Forty-one studies met our inclusion criteria: ten investigated accidents/injuries; eight asthma; three other atopic diseases; ten overweight/obesity; ten studied other illnesses (eight from low-and middle-income countries (LMICs)). Half of the studies investigated maternal perinatal mental health, 17% investigated paternal mental disorder and 87% examined maternal depression. Meta-analysis revealed significantly higher rates of injuries (OR = 1.15, 95% CI 1.04-1.26), asthma (OR = 1.26, 95% CI 1.12-1.41) and outcomes recorded in LMICs (malnutrition: OR = 2.55, 95% CI 1.74-3.73; diarrhoea: OR = 2.16, 95% CI 1.65-2.84). Evidence was inconclusive for obesity and other atopic disorders. Children of parents with mental disorder have health disadvantages; however, the evidence base is limited to risks for offspring following postnatal depression in mothers and there is little focus on fathers in the literature. Understanding the physical health risks of these vulnerable children is vital to improving lives. Future work should focus on discovering mechanisms linking physical and mental health across generations. None.</description><subject>Accidents</subject><subject>Anxiety</subject><subject>Asthma</subject><subject>Atopic</subject><subject>Atopy</subject><subject>Body weight</subject><subject>Child Health - statistics &amp; numerical data</subject><subject>Child of Impaired Parents - statistics &amp; numerical data</subject><subject>Childhood obesity</subject><subject>Children</subject><subject>Children &amp; youth</subject><subject>Diarrhea</subject><subject>Disease</subject><subject>Family Health - statistics &amp; numerical data</subject><subject>Fathers</subject><subject>Health risks</subject><subject>Health status</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Malnutrition</subject><subject>Maternal characteristics</subject><subject>Maternal depression</subject><subject>Medicin och hälsovetenskap</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental health</subject><subject>Mental Health - statistics &amp; 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Half of the studies investigated maternal perinatal mental health, 17% investigated paternal mental disorder and 87% examined maternal depression. Meta-analysis revealed significantly higher rates of injuries (OR = 1.15, 95% CI 1.04-1.26), asthma (OR = 1.26, 95% CI 1.12-1.41) and outcomes recorded in LMICs (malnutrition: OR = 2.55, 95% CI 1.74-3.73; diarrhoea: OR = 2.16, 95% CI 1.65-2.84). Evidence was inconclusive for obesity and other atopic disorders. Children of parents with mental disorder have health disadvantages; however, the evidence base is limited to risks for offspring following postnatal depression in mothers and there is little focus on fathers in the literature. Understanding the physical health risks of these vulnerable children is vital to improving lives. Future work should focus on discovering mechanisms linking physical and mental health across generations. 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subjects Accidents
Anxiety
Asthma
Atopic
Atopy
Body weight
Child Health - statistics & numerical data
Child of Impaired Parents - statistics & numerical data
Childhood obesity
Children
Children & youth
Diarrhea
Disease
Family Health - statistics & numerical data
Fathers
Health risks
Health status
Humans
Illnesses
Malnutrition
Maternal characteristics
Maternal depression
Medicin och hälsovetenskap
Mental depression
Mental disorders
Mental Disorders - epidemiology
Mental health
Mental Health - statistics & numerical data
Meta-analysis
Mood
Mothers
Mothers - psychology
Obesity
Obsessive compulsive disorder
Offspring
Overweight
Parents & parenting
Parents - psychology
Perinatal
Post traumatic stress disorder
Postpartum depression
Postpartum period
Psychiatry
Psychosis
Review article
Substance use
Systematic review
title Effects of parental mental illness on children's physical health: systematic review and meta-analysis
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