Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males
We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target cell availability in the foreskin. We measured chemokine gene expression and the impact of sexually transmitted infections (STIs) on the densit...
Gespeichert in:
| Veröffentlicht in: | Mucosal immunology 2020-01, Vol.13 (1), p.118-127 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 127 |
|---|---|
| container_issue | 1 |
| container_start_page | 118 |
| container_title | Mucosal immunology |
| container_volume | 13 |
| creator | Gray, Clive M. O’Hagan, Kyle L. Lorenzo-Redondo, Ramon Olivier, Abraham J. Amu, Sylvie Chigorimbo-Murefu, Nyaradzo Harryparsad, Rushil Sebaa, Shorok Maziya, Lungile Dietrich, Janan Otwombe, Kennedy Martinson, Neil Ferrian, Selena Mkhize, Nonhlanhla N. Lewis, David A. Lang, Dirk Carias, Ann M. Jaspan, Heather B. Wilson, Douglas P. K. McGilvray, Marcus Cianci, Gianguido C. Anderson, Meegan R. Dinh, Minh H. Williamson, Anna-Lise Passmore, Jo-Ann S. Chiodi, Francesca Hope, Thomas J. |
| description | We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target cell availability in the foreskin. We measured chemokine gene expression and the impact of sexually transmitted infections (STIs) on the density and location of T and Langerhans cells. Chemokine C–C ligand 27 (CCL27) was expressed 6.94-fold higher in the inner foreskin when compared with the outer foreskin. We show that the density of CD4
+
CCR5
+
cells/mm
2
was higher in the epithelium of the inner foreskin, regardless of STI status, in parallel with higher CCL27 gene expression. In the presence of STIs, there were higher numbers of CD4
+
CCR5
+
cells/mm
2
cells in the sub-stratum of the outer and inner foreskin with concurrently higher number of CD207
+
Langerhans cells (LC) in both tissues, with the latter cells being closer to the keratin surface of the outer FS in the presence of an STI. When we tested the ability of exogenous CCL27 to induce T-cell migration in foreskin tissue, CD4 + T cells were able to relocate to the inner foreskin epithelium in response. We provide novel insight into the impact CCL27 and STIs on immune and HIV-1 target cell changes in the foreskin. |
| doi_str_mv | 10.1038/s41385-019-0209-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_476332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2327335448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-a004ced85f9884b001a8fea830c2dd651a709542f2361ae1c52028a91e3f21653</originalsourceid><addsrcrecordid>eNp9Uk1v1DAQjRCIloUfwAVZ4sKBgL-TXJCqFdCVKnHg42rNJpNdt4ldbKewN_4DZ_4cvwSHXQpFgpNH8968Gc-8onjI6DNGRf08SiZqVVLWlJTTptS3imPWCFUKqfTtn7HICGuOinsxnlOqKVXibnEkmGZNpflx8W01XkKbiO9Ju8XRX1iHZPn9y9clGewGXEd49ZT0PmDMEAEHyY87MgMRP08wDDuSArg42pSwI9b12CbrXSTekdPVh5KRBGGDibQ4DASuwA6wtoNNOzILdn7A2KJL5K2f0pac9MG24MgIOX-_uNPDEPHB4V0U71-9fLc8Lc_evF4tT87KVgmdSqBUttjVqm_qWq4pZVD3CLWgLe86rRhUtFGS91xoBshaxSmvoWEoes60Eoui3OvGT3g5rc1lsCOEnfFgzSF1kSM0stJC8Mx_sednZMRuHj_AcKPsJuLs1mz8ldENk1rXWeDJQSD4jxPGZEYb5wWBQz9FwwXVMl8yX3BRPP6Leu6n4PI6DJeVonkcIf_LErwSQkk5t2V7Vht8jAH765EZNbOlzN5SJlvKzJYyOtc8-vOv1xW_PJQJ_LC8DLkNht-t_636A35T2OA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2327335448</pqid></control><display><type>article</type><title>Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>SWEPUB Freely available online</source><creator>Gray, Clive M. ; O’Hagan, Kyle L. ; Lorenzo-Redondo, Ramon ; Olivier, Abraham J. ; Amu, Sylvie ; Chigorimbo-Murefu, Nyaradzo ; Harryparsad, Rushil ; Sebaa, Shorok ; Maziya, Lungile ; Dietrich, Janan ; Otwombe, Kennedy ; Martinson, Neil ; Ferrian, Selena ; Mkhize, Nonhlanhla N. ; Lewis, David A. ; Lang, Dirk ; Carias, Ann M. ; Jaspan, Heather B. ; Wilson, Douglas P. K. ; McGilvray, Marcus ; Cianci, Gianguido C. ; Anderson, Meegan R. ; Dinh, Minh H. ; Williamson, Anna-Lise ; Passmore, Jo-Ann S. ; Chiodi, Francesca ; Hope, Thomas J.</creator><creatorcontrib>Gray, Clive M. ; O’Hagan, Kyle L. ; Lorenzo-Redondo, Ramon ; Olivier, Abraham J. ; Amu, Sylvie ; Chigorimbo-Murefu, Nyaradzo ; Harryparsad, Rushil ; Sebaa, Shorok ; Maziya, Lungile ; Dietrich, Janan ; Otwombe, Kennedy ; Martinson, Neil ; Ferrian, Selena ; Mkhize, Nonhlanhla N. ; Lewis, David A. ; Lang, Dirk ; Carias, Ann M. ; Jaspan, Heather B. ; Wilson, Douglas P. K. ; McGilvray, Marcus ; Cianci, Gianguido C. ; Anderson, Meegan R. ; Dinh, Minh H. ; Williamson, Anna-Lise ; Passmore, Jo-Ann S. ; Chiodi, Francesca ; Hope, Thomas J.</creatorcontrib><description>We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target cell availability in the foreskin. We measured chemokine gene expression and the impact of sexually transmitted infections (STIs) on the density and location of T and Langerhans cells. Chemokine C–C ligand 27 (CCL27) was expressed 6.94-fold higher in the inner foreskin when compared with the outer foreskin. We show that the density of CD4
+
CCR5
+
cells/mm
2
was higher in the epithelium of the inner foreskin, regardless of STI status, in parallel with higher CCL27 gene expression. In the presence of STIs, there were higher numbers of CD4
+
CCR5
+
cells/mm
2
cells in the sub-stratum of the outer and inner foreskin with concurrently higher number of CD207
+
Langerhans cells (LC) in both tissues, with the latter cells being closer to the keratin surface of the outer FS in the presence of an STI. When we tested the ability of exogenous CCL27 to induce T-cell migration in foreskin tissue, CD4 + T cells were able to relocate to the inner foreskin epithelium in response. We provide novel insight into the impact CCL27 and STIs on immune and HIV-1 target cell changes in the foreskin.</description><identifier>ISSN: 1933-0219</identifier><identifier>EISSN: 1935-3456</identifier><identifier>DOI: 10.1038/s41385-019-0209-6</identifier><identifier>PMID: 31619762</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adolescent ; Adult ; Allergology ; Antibodies ; Bacterial Infections - immunology ; Bacterial Infections - therapy ; Biomedical and Life Sciences ; Biomedicine ; CCR5 protein ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; Cell adhesion & migration ; Cell migration ; Cell Movement ; Chemokine CCL27 - genetics ; Chemokine CCL27 - metabolism ; Chemokines ; Circumcision ; Circumcision, Male ; Epithelium ; Foreskin - metabolism ; Foreskin - pathology ; Gastroenterology ; Gene expression ; Gene Expression Regulation ; HIV ; HIV Infections - immunology ; HIV Infections - therapy ; HIV-1 - physiology ; Human immunodeficiency virus ; Humans ; Immunology ; Keratin ; Langerhans cells ; Langerhans Cells - immunology ; Ligands ; Lymphocytes T ; Male ; Males ; Sexually Transmitted Diseases ; South Africa ; STD ; Young Adult</subject><ispartof>Mucosal immunology, 2020-01, Vol.13 (1), p.118-127</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2019. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-a004ced85f9884b001a8fea830c2dd651a709542f2361ae1c52028a91e3f21653</citedby><cites>FETCH-LOGICAL-c536t-a004ced85f9884b001a8fea830c2dd651a709542f2361ae1c52028a91e3f21653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31619762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:142546705$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Gray, Clive M.</creatorcontrib><creatorcontrib>O’Hagan, Kyle L.</creatorcontrib><creatorcontrib>Lorenzo-Redondo, Ramon</creatorcontrib><creatorcontrib>Olivier, Abraham J.</creatorcontrib><creatorcontrib>Amu, Sylvie</creatorcontrib><creatorcontrib>Chigorimbo-Murefu, Nyaradzo</creatorcontrib><creatorcontrib>Harryparsad, Rushil</creatorcontrib><creatorcontrib>Sebaa, Shorok</creatorcontrib><creatorcontrib>Maziya, Lungile</creatorcontrib><creatorcontrib>Dietrich, Janan</creatorcontrib><creatorcontrib>Otwombe, Kennedy</creatorcontrib><creatorcontrib>Martinson, Neil</creatorcontrib><creatorcontrib>Ferrian, Selena</creatorcontrib><creatorcontrib>Mkhize, Nonhlanhla N.</creatorcontrib><creatorcontrib>Lewis, David A.</creatorcontrib><creatorcontrib>Lang, Dirk</creatorcontrib><creatorcontrib>Carias, Ann M.</creatorcontrib><creatorcontrib>Jaspan, Heather B.</creatorcontrib><creatorcontrib>Wilson, Douglas P. K.</creatorcontrib><creatorcontrib>McGilvray, Marcus</creatorcontrib><creatorcontrib>Cianci, Gianguido C.</creatorcontrib><creatorcontrib>Anderson, Meegan R.</creatorcontrib><creatorcontrib>Dinh, Minh H.</creatorcontrib><creatorcontrib>Williamson, Anna-Lise</creatorcontrib><creatorcontrib>Passmore, Jo-Ann S.</creatorcontrib><creatorcontrib>Chiodi, Francesca</creatorcontrib><creatorcontrib>Hope, Thomas J.</creatorcontrib><title>Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males</title><title>Mucosal immunology</title><addtitle>Mucosal Immunol</addtitle><addtitle>Mucosal Immunol</addtitle><description>We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target cell availability in the foreskin. We measured chemokine gene expression and the impact of sexually transmitted infections (STIs) on the density and location of T and Langerhans cells. Chemokine C–C ligand 27 (CCL27) was expressed 6.94-fold higher in the inner foreskin when compared with the outer foreskin. We show that the density of CD4
+
CCR5
+
cells/mm
2
was higher in the epithelium of the inner foreskin, regardless of STI status, in parallel with higher CCL27 gene expression. In the presence of STIs, there were higher numbers of CD4
+
CCR5
+
cells/mm
2
cells in the sub-stratum of the outer and inner foreskin with concurrently higher number of CD207
+
Langerhans cells (LC) in both tissues, with the latter cells being closer to the keratin surface of the outer FS in the presence of an STI. When we tested the ability of exogenous CCL27 to induce T-cell migration in foreskin tissue, CD4 + T cells were able to relocate to the inner foreskin epithelium in response. We provide novel insight into the impact CCL27 and STIs on immune and HIV-1 target cell changes in the foreskin.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergology</subject><subject>Antibodies</subject><subject>Bacterial Infections - immunology</subject><subject>Bacterial Infections - therapy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CCR5 protein</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Cell adhesion & migration</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Chemokine CCL27 - genetics</subject><subject>Chemokine CCL27 - metabolism</subject><subject>Chemokines</subject><subject>Circumcision</subject><subject>Circumcision, Male</subject><subject>Epithelium</subject><subject>Foreskin - metabolism</subject><subject>Foreskin - pathology</subject><subject>Gastroenterology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>HIV</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - therapy</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunology</subject><subject>Keratin</subject><subject>Langerhans cells</subject><subject>Langerhans Cells - immunology</subject><subject>Ligands</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Males</subject><subject>Sexually Transmitted Diseases</subject><subject>South Africa</subject><subject>STD</subject><subject>Young Adult</subject><issn>1933-0219</issn><issn>1935-3456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNp9Uk1v1DAQjRCIloUfwAVZ4sKBgL-TXJCqFdCVKnHg42rNJpNdt4ldbKewN_4DZ_4cvwSHXQpFgpNH8968Gc-8onjI6DNGRf08SiZqVVLWlJTTptS3imPWCFUKqfTtn7HICGuOinsxnlOqKVXibnEkmGZNpflx8W01XkKbiO9Ju8XRX1iHZPn9y9clGewGXEd49ZT0PmDMEAEHyY87MgMRP08wDDuSArg42pSwI9b12CbrXSTekdPVh5KRBGGDibQ4DASuwA6wtoNNOzILdn7A2KJL5K2f0pac9MG24MgIOX-_uNPDEPHB4V0U71-9fLc8Lc_evF4tT87KVgmdSqBUttjVqm_qWq4pZVD3CLWgLe86rRhUtFGS91xoBshaxSmvoWEoes60Eoui3OvGT3g5rc1lsCOEnfFgzSF1kSM0stJC8Mx_sednZMRuHj_AcKPsJuLs1mz8ldENk1rXWeDJQSD4jxPGZEYb5wWBQz9FwwXVMl8yX3BRPP6Leu6n4PI6DJeVonkcIf_LErwSQkk5t2V7Vht8jAH765EZNbOlzN5SJlvKzJYyOtc8-vOv1xW_PJQJ_LC8DLkNht-t_636A35T2OA</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Gray, Clive M.</creator><creator>O’Hagan, Kyle L.</creator><creator>Lorenzo-Redondo, Ramon</creator><creator>Olivier, Abraham J.</creator><creator>Amu, Sylvie</creator><creator>Chigorimbo-Murefu, Nyaradzo</creator><creator>Harryparsad, Rushil</creator><creator>Sebaa, Shorok</creator><creator>Maziya, Lungile</creator><creator>Dietrich, Janan</creator><creator>Otwombe, Kennedy</creator><creator>Martinson, Neil</creator><creator>Ferrian, Selena</creator><creator>Mkhize, Nonhlanhla N.</creator><creator>Lewis, David A.</creator><creator>Lang, Dirk</creator><creator>Carias, Ann M.</creator><creator>Jaspan, Heather B.</creator><creator>Wilson, Douglas P. K.</creator><creator>McGilvray, Marcus</creator><creator>Cianci, Gianguido C.</creator><creator>Anderson, Meegan R.</creator><creator>Dinh, Minh H.</creator><creator>Williamson, Anna-Lise</creator><creator>Passmore, Jo-Ann S.</creator><creator>Chiodi, Francesca</creator><creator>Hope, Thomas J.</creator><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20200101</creationdate><title>Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males</title><author>Gray, Clive M. ; O’Hagan, Kyle L. ; Lorenzo-Redondo, Ramon ; Olivier, Abraham J. ; Amu, Sylvie ; Chigorimbo-Murefu, Nyaradzo ; Harryparsad, Rushil ; Sebaa, Shorok ; Maziya, Lungile ; Dietrich, Janan ; Otwombe, Kennedy ; Martinson, Neil ; Ferrian, Selena ; Mkhize, Nonhlanhla N. ; Lewis, David A. ; Lang, Dirk ; Carias, Ann M. ; Jaspan, Heather B. ; Wilson, Douglas P. K. ; McGilvray, Marcus ; Cianci, Gianguido C. ; Anderson, Meegan R. ; Dinh, Minh H. ; Williamson, Anna-Lise ; Passmore, Jo-Ann S. ; Chiodi, Francesca ; Hope, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-a004ced85f9884b001a8fea830c2dd651a709542f2361ae1c52028a91e3f21653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergology</topic><topic>Antibodies</topic><topic>Bacterial Infections - immunology</topic><topic>Bacterial Infections - therapy</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CCR5 protein</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Cell adhesion & migration</topic><topic>Cell migration</topic><topic>Cell Movement</topic><topic>Chemokine CCL27 - genetics</topic><topic>Chemokine CCL27 - metabolism</topic><topic>Chemokines</topic><topic>Circumcision</topic><topic>Circumcision, Male</topic><topic>Epithelium</topic><topic>Foreskin - metabolism</topic><topic>Foreskin - pathology</topic><topic>Gastroenterology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>HIV</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - therapy</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunology</topic><topic>Keratin</topic><topic>Langerhans cells</topic><topic>Langerhans Cells - immunology</topic><topic>Ligands</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Males</topic><topic>Sexually Transmitted Diseases</topic><topic>South Africa</topic><topic>STD</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gray, Clive M.</creatorcontrib><creatorcontrib>O’Hagan, Kyle L.</creatorcontrib><creatorcontrib>Lorenzo-Redondo, Ramon</creatorcontrib><creatorcontrib>Olivier, Abraham J.</creatorcontrib><creatorcontrib>Amu, Sylvie</creatorcontrib><creatorcontrib>Chigorimbo-Murefu, Nyaradzo</creatorcontrib><creatorcontrib>Harryparsad, Rushil</creatorcontrib><creatorcontrib>Sebaa, Shorok</creatorcontrib><creatorcontrib>Maziya, Lungile</creatorcontrib><creatorcontrib>Dietrich, Janan</creatorcontrib><creatorcontrib>Otwombe, Kennedy</creatorcontrib><creatorcontrib>Martinson, Neil</creatorcontrib><creatorcontrib>Ferrian, Selena</creatorcontrib><creatorcontrib>Mkhize, Nonhlanhla N.</creatorcontrib><creatorcontrib>Lewis, David A.</creatorcontrib><creatorcontrib>Lang, Dirk</creatorcontrib><creatorcontrib>Carias, Ann M.</creatorcontrib><creatorcontrib>Jaspan, Heather B.</creatorcontrib><creatorcontrib>Wilson, Douglas P. K.</creatorcontrib><creatorcontrib>McGilvray, Marcus</creatorcontrib><creatorcontrib>Cianci, Gianguido C.</creatorcontrib><creatorcontrib>Anderson, Meegan R.</creatorcontrib><creatorcontrib>Dinh, Minh H.</creatorcontrib><creatorcontrib>Williamson, Anna-Lise</creatorcontrib><creatorcontrib>Passmore, Jo-Ann S.</creatorcontrib><creatorcontrib>Chiodi, Francesca</creatorcontrib><creatorcontrib>Hope, Thomas J.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Mucosal immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gray, Clive M.</au><au>O’Hagan, Kyle L.</au><au>Lorenzo-Redondo, Ramon</au><au>Olivier, Abraham J.</au><au>Amu, Sylvie</au><au>Chigorimbo-Murefu, Nyaradzo</au><au>Harryparsad, Rushil</au><au>Sebaa, Shorok</au><au>Maziya, Lungile</au><au>Dietrich, Janan</au><au>Otwombe, Kennedy</au><au>Martinson, Neil</au><au>Ferrian, Selena</au><au>Mkhize, Nonhlanhla N.</au><au>Lewis, David A.</au><au>Lang, Dirk</au><au>Carias, Ann M.</au><au>Jaspan, Heather B.</au><au>Wilson, Douglas P. K.</au><au>McGilvray, Marcus</au><au>Cianci, Gianguido C.</au><au>Anderson, Meegan R.</au><au>Dinh, Minh H.</au><au>Williamson, Anna-Lise</au><au>Passmore, Jo-Ann S.</au><au>Chiodi, Francesca</au><au>Hope, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males</atitle><jtitle>Mucosal immunology</jtitle><stitle>Mucosal Immunol</stitle><addtitle>Mucosal Immunol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>13</volume><issue>1</issue><spage>118</spage><epage>127</epage><pages>118-127</pages><issn>1933-0219</issn><eissn>1935-3456</eissn><abstract>We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target cell availability in the foreskin. We measured chemokine gene expression and the impact of sexually transmitted infections (STIs) on the density and location of T and Langerhans cells. Chemokine C–C ligand 27 (CCL27) was expressed 6.94-fold higher in the inner foreskin when compared with the outer foreskin. We show that the density of CD4
+
CCR5
+
cells/mm
2
was higher in the epithelium of the inner foreskin, regardless of STI status, in parallel with higher CCL27 gene expression. In the presence of STIs, there were higher numbers of CD4
+
CCR5
+
cells/mm
2
cells in the sub-stratum of the outer and inner foreskin with concurrently higher number of CD207
+
Langerhans cells (LC) in both tissues, with the latter cells being closer to the keratin surface of the outer FS in the presence of an STI. When we tested the ability of exogenous CCL27 to induce T-cell migration in foreskin tissue, CD4 + T cells were able to relocate to the inner foreskin epithelium in response. We provide novel insight into the impact CCL27 and STIs on immune and HIV-1 target cell changes in the foreskin.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>31619762</pmid><doi>10.1038/s41385-019-0209-6</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1933-0219 |
| ispartof | Mucosal immunology, 2020-01, Vol.13 (1), p.118-127 |
| issn | 1933-0219 1935-3456 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_476332 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Adolescent Adult Allergology Antibodies Bacterial Infections - immunology Bacterial Infections - therapy Biomedical and Life Sciences Biomedicine CCR5 protein CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell adhesion & migration Cell migration Cell Movement Chemokine CCL27 - genetics Chemokine CCL27 - metabolism Chemokines Circumcision Circumcision, Male Epithelium Foreskin - metabolism Foreskin - pathology Gastroenterology Gene expression Gene Expression Regulation HIV HIV Infections - immunology HIV Infections - therapy HIV-1 - physiology Human immunodeficiency virus Humans Immunology Keratin Langerhans cells Langerhans Cells - immunology Ligands Lymphocytes T Male Males Sexually Transmitted Diseases South Africa STD Young Adult |
| title | Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T05%3A21%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20chemokine%20C%E2%80%93C%20ligand%2027,%20foreskin%20anatomy%20and%20sexually%20transmitted%20infections%20on%20HIV-1%20target%20cell%20availability%20in%20adolescent%20South%20African%20males&rft.jtitle=Mucosal%20immunology&rft.au=Gray,%20Clive%20M.&rft.date=2020-01-01&rft.volume=13&rft.issue=1&rft.spage=118&rft.epage=127&rft.pages=118-127&rft.issn=1933-0219&rft.eissn=1935-3456&rft_id=info:doi/10.1038/s41385-019-0209-6&rft_dat=%3Cproquest_swepu%3E2327335448%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2327335448&rft_id=info:pmid/31619762&rfr_iscdi=true |