Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia
[Display omitted] •One-carbon metabolism and the APOEε4 allele variant could interact in dementia.•This potential interaction has not been addressed in prognostic dementia studies.•We measured metabolites in sera in a longitudinal study on cognition in dementia.•Choline oxidation metabolites seem to...
Gespeichert in:
| Veröffentlicht in: | Brain research 2020-01, Vol.1726, p.146519-146519, Article 146519 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 146519 |
|---|---|
| container_issue | |
| container_start_page | 146519 |
| container_title | Brain research |
| container_volume | 1726 |
| creator | Hildre, Audun Skjaerseth Solvang, Stein-Erik Hafstad Aarsland, Dag Midtun, Øivind McCann, Adrian Ervik, Arne Olav Nygård, Ottar Ueland, Per Magne Nordrehaug, Jan Erik Giil, Lasse Melvaer |
| description | [Display omitted]
•One-carbon metabolism and the APOEε4 allele variant could interact in dementia.•This potential interaction has not been addressed in prognostic dementia studies.•We measured metabolites in sera in a longitudinal study on cognition in dementia.•Choline oxidation metabolites seem to improve cognitive prognosis in APOEε4 carriers.•In comparison, they may be detrimental to cognitive prognosis in non-carriers.
Metabolites involved in one-carbon metabolism (OCM) may predict cognitive prognosis in dementia. The link between OCM, apolipoprotein E (APOE), and DNA methylation creates a biologically plausible mechanism of interaction.
To assess OCM metabolites as predictors of 5-year cognitive prognosis in patients with mild dementia, and in subgroups defined by the APOEε4 allele variant.
We followed one-hundred and fifty-two patients with mild dementia (86 with Alzheimer’s disease, 66 with Lewy body dementia, including 90 with at least one APOEε4 allele) for 5 years with annual Mini-Mental State Examinations (MMSE). Total homocysteine, methionine, choline, betaine, dimethylglycine, sarcosine, folate, cobalamin and pyridoxal 5′-phoshate were measured in serum at baseline. We used linear mixed models to assess metabolite-MMSE associations, including 3-way interactions between metabolites, time, and APOEε4. False-discovery rate adjusted p-values (Q-values) are reported.
Metabolite concentrations were not different in patients with dementia according to the presence of APOEε4. Overall, serum concentration of total homocysteine was inversely associated with MMSE performance, while betaine was positively associated with MMSE (Q |
| doi_str_mv | 10.1016/j.brainres.2019.146519 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_476139</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899319305736</els_id><sourcerecordid>2309474681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3719-5d35072e7f87713914d89137772a0c111838d055e791d9c8cd9e22d5f8ca55203</originalsourceid><addsrcrecordid>eNqFkkuOEzEQhlsIxISBK4y8ZNPBj267vQNFvKSR2MDacuzqiUPabmwnmVyGW3ANzoSnOxlWiJXtqu-v3y5XVd0QvCSY8Dfb5Tpq5yOkJcVELknDWyKfVAvSCVpz2uCn1QJjzOtOSnZVvUhpW46MSfy8umKEtw1v8KL6uQrDGDz4nFDoUd4AMpuwcx5QuHdWZxc8GnXeHPUJDcG6_jRBOqVg3JxeQz4C-Dk-FvEYxhgyOI9-_2rQHZRiBx2d9hlpb5EJd95ldwBkwUxWbvJw0y2OLm9KYigHp19Wz3q9S_DqvF5X3z68_7r6VN9--fh59e62NkwQWbeWtVhQEH0nBGGSNLaThAkhqMaGENKxzuK2BSGJlaYzVgKltu07o9uWYnZd1XPddIRxv1ZjdIOOJxW0U-fQ97ID1Qhe6hde_pMvb7d_RRchaWjLJZ-0r2dtAX_sIWU1uGRgt9Mewj4pyrBsRMM7UlA-oyaGlCL0j0YEq4c5UFt1mQP1MAdqnoMivDl77NcD2EfZ5eML8HYGoHT14CCqZEr_DVgXwWRlg_ufxx81DMxL</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2309474681</pqid></control><display><type>article</type><title>Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Hildre, Audun Skjaerseth ; Solvang, Stein-Erik Hafstad ; Aarsland, Dag ; Midtun, Øivind ; McCann, Adrian ; Ervik, Arne Olav ; Nygård, Ottar ; Ueland, Per Magne ; Nordrehaug, Jan Erik ; Giil, Lasse Melvaer</creator><creatorcontrib>Hildre, Audun Skjaerseth ; Solvang, Stein-Erik Hafstad ; Aarsland, Dag ; Midtun, Øivind ; McCann, Adrian ; Ervik, Arne Olav ; Nygård, Ottar ; Ueland, Per Magne ; Nordrehaug, Jan Erik ; Giil, Lasse Melvaer</creatorcontrib><description>[Display omitted]
•One-carbon metabolism and the APOEε4 allele variant could interact in dementia.•This potential interaction has not been addressed in prognostic dementia studies.•We measured metabolites in sera in a longitudinal study on cognition in dementia.•Choline oxidation metabolites seem to improve cognitive prognosis in APOEε4 carriers.•In comparison, they may be detrimental to cognitive prognosis in non-carriers.
Metabolites involved in one-carbon metabolism (OCM) may predict cognitive prognosis in dementia. The link between OCM, apolipoprotein E (APOE), and DNA methylation creates a biologically plausible mechanism of interaction.
To assess OCM metabolites as predictors of 5-year cognitive prognosis in patients with mild dementia, and in subgroups defined by the APOEε4 allele variant.
We followed one-hundred and fifty-two patients with mild dementia (86 with Alzheimer’s disease, 66 with Lewy body dementia, including 90 with at least one APOEε4 allele) for 5 years with annual Mini-Mental State Examinations (MMSE). Total homocysteine, methionine, choline, betaine, dimethylglycine, sarcosine, folate, cobalamin and pyridoxal 5′-phoshate were measured in serum at baseline. We used linear mixed models to assess metabolite-MMSE associations, including 3-way interactions between metabolites, time, and APOEε4. False-discovery rate adjusted p-values (Q-values) are reported.
Metabolite concentrations were not different in patients with dementia according to the presence of APOEε4. Overall, serum concentration of total homocysteine was inversely associated with MMSE performance, while betaine was positively associated with MMSE (Q < 0.05), but neither was associated with MMSE decline. Serum concentrations of betaine, dimethylglycine and sarcosine, however, were associated with slower MMSE decline in patients with APOEε4, but with faster MMSE decline in patients without the allele (all 3-way interactions: Q < 0.05).
Components of the choline oxidation pathway are associated with a better cognitive prognosis in APOEε4 carriers and a worse cognitive prognosis in non-carriers. Further research investigating targeted metabolic interventions according to APOE allele status is warranted.</description><identifier>ISSN: 0006-8993</identifier><identifier>ISSN: 1872-6240</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2019.146519</identifier><identifier>PMID: 31654640</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Alzheimer Disease - diagnosis ; Alzheimer Disease - genetics ; Alzheimer Disease - metabolism ; Alzheimer’s disease ; APOE ; APOE4 ; APOE4ε4 ; Apolipoprotein E ; Apolipoprotein E4 - genetics ; Betaine ; Choline - metabolism ; Choline oxidation ; Cognitive decline ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - genetics ; Cognitive Dysfunction - metabolism ; Dementia ; Dementia - diagnosis ; Dementia - genetics ; Dementia - metabolism ; Dimethylglycine ; Effect modification ; Female ; Humans ; Interaction ; Lewy body dementia ; Lewy Body Disease - diagnosis ; Lewy Body Disease - genetics ; Lewy Body Disease - metabolism ; Male ; Medicin och hälsovetenskap ; Mini-mental state examination ; MMSE-decline ; Prognosis</subject><ispartof>Brain research, 2020-01, Vol.1726, p.146519-146519, Article 146519</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3719-5d35072e7f87713914d89137772a0c111838d055e791d9c8cd9e22d5f8ca55203</citedby><cites>FETCH-LOGICAL-c3719-5d35072e7f87713914d89137772a0c111838d055e791d9c8cd9e22d5f8ca55203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2019.146519$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31654640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:142569639$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Hildre, Audun Skjaerseth</creatorcontrib><creatorcontrib>Solvang, Stein-Erik Hafstad</creatorcontrib><creatorcontrib>Aarsland, Dag</creatorcontrib><creatorcontrib>Midtun, Øivind</creatorcontrib><creatorcontrib>McCann, Adrian</creatorcontrib><creatorcontrib>Ervik, Arne Olav</creatorcontrib><creatorcontrib>Nygård, Ottar</creatorcontrib><creatorcontrib>Ueland, Per Magne</creatorcontrib><creatorcontrib>Nordrehaug, Jan Erik</creatorcontrib><creatorcontrib>Giil, Lasse Melvaer</creatorcontrib><title>Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>[Display omitted]
•One-carbon metabolism and the APOEε4 allele variant could interact in dementia.•This potential interaction has not been addressed in prognostic dementia studies.•We measured metabolites in sera in a longitudinal study on cognition in dementia.•Choline oxidation metabolites seem to improve cognitive prognosis in APOEε4 carriers.•In comparison, they may be detrimental to cognitive prognosis in non-carriers.
Metabolites involved in one-carbon metabolism (OCM) may predict cognitive prognosis in dementia. The link between OCM, apolipoprotein E (APOE), and DNA methylation creates a biologically plausible mechanism of interaction.
To assess OCM metabolites as predictors of 5-year cognitive prognosis in patients with mild dementia, and in subgroups defined by the APOEε4 allele variant.
We followed one-hundred and fifty-two patients with mild dementia (86 with Alzheimer’s disease, 66 with Lewy body dementia, including 90 with at least one APOEε4 allele) for 5 years with annual Mini-Mental State Examinations (MMSE). Total homocysteine, methionine, choline, betaine, dimethylglycine, sarcosine, folate, cobalamin and pyridoxal 5′-phoshate were measured in serum at baseline. We used linear mixed models to assess metabolite-MMSE associations, including 3-way interactions between metabolites, time, and APOEε4. False-discovery rate adjusted p-values (Q-values) are reported.
Metabolite concentrations were not different in patients with dementia according to the presence of APOEε4. Overall, serum concentration of total homocysteine was inversely associated with MMSE performance, while betaine was positively associated with MMSE (Q < 0.05), but neither was associated with MMSE decline. Serum concentrations of betaine, dimethylglycine and sarcosine, however, were associated with slower MMSE decline in patients with APOEε4, but with faster MMSE decline in patients without the allele (all 3-way interactions: Q < 0.05).
Components of the choline oxidation pathway are associated with a better cognitive prognosis in APOEε4 carriers and a worse cognitive prognosis in non-carriers. Further research investigating targeted metabolic interventions according to APOE allele status is warranted.</description><subject>Aged</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer’s disease</subject><subject>APOE</subject><subject>APOE4</subject><subject>APOE4ε4</subject><subject>Apolipoprotein E</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Betaine</subject><subject>Choline - metabolism</subject><subject>Choline oxidation</subject><subject>Cognitive decline</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - genetics</subject><subject>Cognitive Dysfunction - metabolism</subject><subject>Dementia</subject><subject>Dementia - diagnosis</subject><subject>Dementia - genetics</subject><subject>Dementia - metabolism</subject><subject>Dimethylglycine</subject><subject>Effect modification</subject><subject>Female</subject><subject>Humans</subject><subject>Interaction</subject><subject>Lewy body dementia</subject><subject>Lewy Body Disease - diagnosis</subject><subject>Lewy Body Disease - genetics</subject><subject>Lewy Body Disease - metabolism</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Mini-mental state examination</subject><subject>MMSE-decline</subject><subject>Prognosis</subject><issn>0006-8993</issn><issn>1872-6240</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuOEzEQhlsIxISBK4y8ZNPBj267vQNFvKSR2MDacuzqiUPabmwnmVyGW3ANzoSnOxlWiJXtqu-v3y5XVd0QvCSY8Dfb5Tpq5yOkJcVELknDWyKfVAvSCVpz2uCn1QJjzOtOSnZVvUhpW46MSfy8umKEtw1v8KL6uQrDGDz4nFDoUd4AMpuwcx5QuHdWZxc8GnXeHPUJDcG6_jRBOqVg3JxeQz4C-Dk-FvEYxhgyOI9-_2rQHZRiBx2d9hlpb5EJd95ldwBkwUxWbvJw0y2OLm9KYigHp19Wz3q9S_DqvF5X3z68_7r6VN9--fh59e62NkwQWbeWtVhQEH0nBGGSNLaThAkhqMaGENKxzuK2BSGJlaYzVgKltu07o9uWYnZd1XPddIRxv1ZjdIOOJxW0U-fQ97ID1Qhe6hde_pMvb7d_RRchaWjLJZ-0r2dtAX_sIWU1uGRgt9Mewj4pyrBsRMM7UlA-oyaGlCL0j0YEq4c5UFt1mQP1MAdqnoMivDl77NcD2EfZ5eML8HYGoHT14CCqZEr_DVgXwWRlg_ufxx81DMxL</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Hildre, Audun Skjaerseth</creator><creator>Solvang, Stein-Erik Hafstad</creator><creator>Aarsland, Dag</creator><creator>Midtun, Øivind</creator><creator>McCann, Adrian</creator><creator>Ervik, Arne Olav</creator><creator>Nygård, Ottar</creator><creator>Ueland, Per Magne</creator><creator>Nordrehaug, Jan Erik</creator><creator>Giil, Lasse Melvaer</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20200101</creationdate><title>Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia</title><author>Hildre, Audun Skjaerseth ; Solvang, Stein-Erik Hafstad ; Aarsland, Dag ; Midtun, Øivind ; McCann, Adrian ; Ervik, Arne Olav ; Nygård, Ottar ; Ueland, Per Magne ; Nordrehaug, Jan Erik ; Giil, Lasse Melvaer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3719-5d35072e7f87713914d89137772a0c111838d055e791d9c8cd9e22d5f8ca55203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer’s disease</topic><topic>APOE</topic><topic>APOE4</topic><topic>APOE4ε4</topic><topic>Apolipoprotein E</topic><topic>Apolipoprotein E4 - genetics</topic><topic>Betaine</topic><topic>Choline - metabolism</topic><topic>Choline oxidation</topic><topic>Cognitive decline</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - genetics</topic><topic>Cognitive Dysfunction - metabolism</topic><topic>Dementia</topic><topic>Dementia - diagnosis</topic><topic>Dementia - genetics</topic><topic>Dementia - metabolism</topic><topic>Dimethylglycine</topic><topic>Effect modification</topic><topic>Female</topic><topic>Humans</topic><topic>Interaction</topic><topic>Lewy body dementia</topic><topic>Lewy Body Disease - diagnosis</topic><topic>Lewy Body Disease - genetics</topic><topic>Lewy Body Disease - metabolism</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Mini-mental state examination</topic><topic>MMSE-decline</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hildre, Audun Skjaerseth</creatorcontrib><creatorcontrib>Solvang, Stein-Erik Hafstad</creatorcontrib><creatorcontrib>Aarsland, Dag</creatorcontrib><creatorcontrib>Midtun, Øivind</creatorcontrib><creatorcontrib>McCann, Adrian</creatorcontrib><creatorcontrib>Ervik, Arne Olav</creatorcontrib><creatorcontrib>Nygård, Ottar</creatorcontrib><creatorcontrib>Ueland, Per Magne</creatorcontrib><creatorcontrib>Nordrehaug, Jan Erik</creatorcontrib><creatorcontrib>Giil, Lasse Melvaer</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hildre, Audun Skjaerseth</au><au>Solvang, Stein-Erik Hafstad</au><au>Aarsland, Dag</au><au>Midtun, Øivind</au><au>McCann, Adrian</au><au>Ervik, Arne Olav</au><au>Nygård, Ottar</au><au>Ueland, Per Magne</au><au>Nordrehaug, Jan Erik</au><au>Giil, Lasse Melvaer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>1726</volume><spage>146519</spage><epage>146519</epage><pages>146519-146519</pages><artnum>146519</artnum><issn>0006-8993</issn><issn>1872-6240</issn><eissn>1872-6240</eissn><abstract>[Display omitted]
•One-carbon metabolism and the APOEε4 allele variant could interact in dementia.•This potential interaction has not been addressed in prognostic dementia studies.•We measured metabolites in sera in a longitudinal study on cognition in dementia.•Choline oxidation metabolites seem to improve cognitive prognosis in APOEε4 carriers.•In comparison, they may be detrimental to cognitive prognosis in non-carriers.
Metabolites involved in one-carbon metabolism (OCM) may predict cognitive prognosis in dementia. The link between OCM, apolipoprotein E (APOE), and DNA methylation creates a biologically plausible mechanism of interaction.
To assess OCM metabolites as predictors of 5-year cognitive prognosis in patients with mild dementia, and in subgroups defined by the APOEε4 allele variant.
We followed one-hundred and fifty-two patients with mild dementia (86 with Alzheimer’s disease, 66 with Lewy body dementia, including 90 with at least one APOEε4 allele) for 5 years with annual Mini-Mental State Examinations (MMSE). Total homocysteine, methionine, choline, betaine, dimethylglycine, sarcosine, folate, cobalamin and pyridoxal 5′-phoshate were measured in serum at baseline. We used linear mixed models to assess metabolite-MMSE associations, including 3-way interactions between metabolites, time, and APOEε4. False-discovery rate adjusted p-values (Q-values) are reported.
Metabolite concentrations were not different in patients with dementia according to the presence of APOEε4. Overall, serum concentration of total homocysteine was inversely associated with MMSE performance, while betaine was positively associated with MMSE (Q < 0.05), but neither was associated with MMSE decline. Serum concentrations of betaine, dimethylglycine and sarcosine, however, were associated with slower MMSE decline in patients with APOEε4, but with faster MMSE decline in patients without the allele (all 3-way interactions: Q < 0.05).
Components of the choline oxidation pathway are associated with a better cognitive prognosis in APOEε4 carriers and a worse cognitive prognosis in non-carriers. Further research investigating targeted metabolic interventions according to APOE allele status is warranted.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31654640</pmid><doi>10.1016/j.brainres.2019.146519</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2020-01, Vol.1726, p.146519-146519, Article 146519 |
| issn | 0006-8993 1872-6240 1872-6240 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_476139 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aged Alzheimer Disease - diagnosis Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer’s disease APOE APOE4 APOE4ε4 Apolipoprotein E Apolipoprotein E4 - genetics Betaine Choline - metabolism Choline oxidation Cognitive decline Cognitive Dysfunction - diagnosis Cognitive Dysfunction - genetics Cognitive Dysfunction - metabolism Dementia Dementia - diagnosis Dementia - genetics Dementia - metabolism Dimethylglycine Effect modification Female Humans Interaction Lewy body dementia Lewy Body Disease - diagnosis Lewy Body Disease - genetics Lewy Body Disease - metabolism Male Medicin och hälsovetenskap Mini-mental state examination MMSE-decline Prognosis |
| title | Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T15%3A43%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Components%20of%20the%20choline%20oxidation%20pathway%20modify%20the%20association%20between%20the%20apolipoprotein%20%CE%B54%20gene%20variant%20and%20cognitive%20decline%20in%20patients%20with%20dementia&rft.jtitle=Brain%20research&rft.au=Hildre,%20Audun%20Skjaerseth&rft.date=2020-01-01&rft.volume=1726&rft.spage=146519&rft.epage=146519&rft.pages=146519-146519&rft.artnum=146519&rft.issn=0006-8993&rft.eissn=1872-6240&rft_id=info:doi/10.1016/j.brainres.2019.146519&rft_dat=%3Cproquest_swepu%3E2309474681%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2309474681&rft_id=info:pmid/31654640&rft_els_id=S0006899319305736&rfr_iscdi=true |