NF‐E2‐related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin‐1 mutated Alzheimer's disease astrocytes

Alzheimer's disease (AD) is a common dementia affecting a vast number of individuals and significantly impairing quality of life. Despite extensive research in animal models and numerous promising treatment trials, there is still no curative treatment for AD. Astrocytes, the most common cell ty...

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Veröffentlicht in:	Glia 2020-03, Vol.68 (3), p.589-599
Hauptverfasser:	Oksanen, Minna, Hyötyläinen, Ida, Trontti, Kalevi, Rolova, Taisia, Wojciechowski, Sara, Koskuvi, Marja, Viitanen, Matti, Levonen, Anna‐Liisa, Hovatta, Iiris, Roybon, Laurent, Lehtonen, Šárka, Kanninen, Katja M., Hämäläinen, Riikka H., Koistinaho, Jari
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Amyloid beta-Peptides - metabolism Amyloidogenic Proteins - metabolism Animal models Animals Antioxidants Antioxidants - pharmacology Astrocytes Astrocytes - drug effects Astrocytes - metabolism Basic Medicine Biologi Biological Sciences Central nervous system Clinical trials Dementia disorders Disease Models, Animal Glutathione Glycolysis Humans Immunologi Immunologi inom det medicinska området Immunology Immunology in the medical area Inflammation Inflammation - metabolism Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Metabolic activation Metabolic rate Metabolism Natural Sciences Naturvetenskap Neurodegenerative diseases NF-E2-Related Factor 2 - metabolism NRF2 Oxidative metabolism Oxidative stress Plaque, Amyloid - metabolism Presenilin 1 Presenilin-1 - metabolism Quality of life Reactive oxygen species Senile plaques
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