Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis

•The apparent effectiveness of d-cycloserine for anxiety disorders has declined over time•This “decline effect” may be due to how d-cycloserine (DCS) has been administered•Our individual participant data meta-analysis included 1047 patients in 21 trials•Number and timing of DCS doses, and severity,...

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Veröffentlicht in:	Journal of anxiety disorders 2019-12, Vol.68, p.102149-102149, Article 102149
Hauptverfasser:	Rosenfield, David, Smits, Jasper A.J., Hofmann, Stefan G., Mataix-Cols, David, de la Cruz, Lorena Fernández, Andersson, Erik, Rück, Christian, Monzani, Benedetta, Pérez-Vigil, Ana, Frumento, Paolo, Davis, Michael, de Kleine, Rianne A., Difede, JoAnn, Dunlop, Boadie W., Farrell, Lara J., Geller, Daniel, Gerardi, Maryrose, Guastella, Adam J., Hendriks, Gert-Jan, Kushner, Matt G., Lee, Francis S., Lenze, Eric J., Levinson, Cheri A., McConnell, Harry, Plag, Jens, Pollack, Mark H., Ressler, Kerry J., Rodebaugh, Thomas L., Rothbaum, Barbara O., Storch, Eric A., Ströhle, Andreas, Tart, Candyce D., Tolin, David F., van Minnen, Agnes, Waters, Allison M., Weems, Carl F., Wilhelm, Sabine, Wyka, Katarzyna, Altemus, Margaret, Anderson, Page, Cukor, Judith, Finck, Claudia, Geffken, Gary R., Golfels, Fabian, Goodman, Wayne K., Gutner, Cassidy A., Heyman, Isobel, Jovanovic, Tanja, Lewin, Adam B., McNamara, Joseph P., Murphy, Tanya K., Norrholm, Seth, Thuras, Paul, Turner, Cynthia, Otto, Michael W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anxiety - psychology Anxiety - therapy Anxiety Disorders - drug therapy Anxiety Disorders - psychology Anxiety Disorders - therapy augmentation Child Combined Modality Therapy - methods Cycloserine - administration & dosage Cycloserine - therapeutic use d-cycloserine decline effect dosing exposure Female Humans Implosive Therapy - methods Male Middle Aged Treatment Outcome Young Adult
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