Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure

Anhedonia is a core symptom of several psychiatric disorders but its biological underpinnings are poorly understood. We performed a genome-wide association study of state anhedonia in 375,275 UK Biobank participants and assessed for genetic correlation between anhedonia and neuropsychiatric conditio...

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Veröffentlicht in:	Translational psychiatry 2019-12, Vol.9 (1), p.327-9, Article 327
Hauptverfasser:	Ward, Joey, Lyall, Laura M., Bethlehem, Richard A. I., Ferguson, Amy, Strawbridge, Rona J., Lyall, Donald M., Cullen, Breda, Graham, Nicholas, Johnston, Keira J. A., Bailey, Mark E. S., Murray, Graham K., Smith, Daniel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 59/57 631/208/212/748 692/699/476/1333 692/699/476/1414 692/699/476/1799 Adult Aged Anhedonia - physiology Behavioral Sciences Biological Psychology Bipolar disorder Brain - diagnostic imaging Cohort Studies Databases, Factual Female Genetic Loci - genetics Genome-Wide Association Study Genomes Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Mental disorders Mental Disorders - diagnostic imaging Mental Disorders - genetics Mental Disorders - physiopathology Middle Aged Multifactorial Inheritance - genetics Neurosciences NMR Nuclear magnetic resonance Obsessive compulsive disorder Parkinson's disease Pharmacotherapy Psychiatry Schizophrenia
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