CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer

To examine the association between CYP2D6 genotype, discontinuation of tamoxifen therapy, and prognosis for breast cancer. We conducted a prospective-retrospective study linking data from a clinical breast cancer register, the Swedish Prescribed Drug Register, and self-reported questionnaires. We ge...

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Veröffentlicht in:	Journal of clinical oncology 2020-02, Vol.38 (6), p.548-557
Hauptverfasser:	He, Wei, Grassmann, Felix, Eriksson, Mikael, Eliasson, Erik, Margolin, Sara, Thorén, Linda, Hall, Per, Czene, Kamila
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents, Hormonal - metabolism Antineoplastic Agents, Hormonal - therapeutic use Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cytochrome P-450 CYP2D6 - genetics Female Genotype Humans Inactivation, Metabolic - genetics Medicin och hälsovetenskap Middle Aged ORIGINAL REPORTS Prognosis Registries Tamoxifen - metabolism Tamoxifen - therapeutic use
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