Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study o...

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Veröffentlicht in:	Lancet neurology 2020-02, Vol.19 (2), p.145-156
Hauptverfasser:	Nicholas, Jennifer, Grossman, Murray, McMillan, Corey T, Massimo, Lauren, Van Deerlin, Vivianna M, Warren, Jason D, Fox, Nick C, Bocchetta, Martina, Boeve, Bradley F, Knopman, David S, Rademakers, Rosa, van Swieten, John C, Meeter, Lieke H, Dopper, Elise GP, Snowden, Julie S, Saxon, Jennifer, Pickering-Brown, Stuart, Le Ber, Isabelle, Brice, Alexis, Caroppo, Paola, Ghidoni, Roberta, Pievani, Michela, Binetti, Giuliano, Dickerson, Bradford C, Lucente, Diane, Graff, Caroline, Ghoshal, Nupur, Galimberti, Daniela, Scarpini, Elio, Mackenzie, Ian R, Hsiung, Ging-Yuek R, Sengdy, Pheth, Boxer, Adam L, Taylor, Joanne B, Synofzik, Matthis, Wilke, Carlo, Sulzer, Patricia, Kwok, John, Lladó, Albert, Borrego-Ecija, Sergi, Santana, Isabel, Almeida, Maria Rosário, Tábuas-Pereira, Miguel, Moreno, Fermin, Barandiaran, Myriam, Indakoetxea, Begoña, Levin, Johannes, Danek, Adrian, Rowe, James B, Anderl-Straub, Sarah, Masellis, Mario, Black, Sandra E, Lautrette, Geraldine, Vandenberghe, Rik, Rogalski, Emily J, Weintraub, Sandra, Gerhard, Alexander, Onyike, Chiadi U, Papageorgiou, Sokratis G, Bras, Jose, Rohrer, Jonathan D, Heller, Carolin, Convery, Rhian S, Shafei, Rachelle M, Jones, David T, Baker, Matt, Gavrilova, Ralitza, Domoto-Reilly, Kimiko, Poos, Jackie M, Van der Ende, Emma L, Panman, Jessica L, Seelaar, Harro, Fostinelli, Silvia, Chiang, Huei-Hsin, Arighi, Andrea, Fenoglio, Chiara, Heuer, Hilary, Miller, Bruce, Karydas, Anna, Fong, Jamie, João Leitão, Maria, Santiago, Beatriz, Ferreira, Carlos, De Arriba, Maria, Tainta, Mikel, Zulaica, Miren, Ferreira, Catarina, Semler, Elisa, Ludolph, Albert, Miltenberger, Gabriel, Rogaeva, Ekaterina, Bruffaerts, Rose, Vandenbulcke, Mathieu, Mesulam, M Marsel, Bigio, Eileen, Kroupis, Christos, Stefanis, Leonidas, Shoesmith, Christien, Robertson, Erik, Geschwind, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age determination Age of Onset Aged Aged, 80 and over Alzheimer's disease Amyotrophic lateral sclerosis C9orf72 Protein - genetics C9orf72 Protein - metabolism Clinical trials Cohort analysis Cohort Studies Death Dementia Dementia disorders Disease Progression Environmental factors Family Female Frontotemporal dementia Frontotemporal Dementia - genetics Frontotemporal Dementia - mortality Humans Life Sciences Literature reviews Male Medical research Middle Aged Mutation Neurodegenerative diseases Phenotype Phenotypes Progranulins - genetics Progranulins - metabolism Retrospective Studies Santé publique et épidémiologie Studies tau Proteins - genetics tau Proteins - metabolism
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