Deciphering the mechanistic effects of eIF4E phosphorylation on mRNA‐cap recognition

The mRNA cap‐binding oncoprotein “eIF4E” is phosphorylated at residue S209 by Mnk kinases, and is closely associated with tumor development and progression. Despite being well‐established, mechanistic details at the molecular level of mRNA recognition by eIF4E due to phosphorylation have not been cl...

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Veröffentlicht in:	Protein science 2020-06, Vol.29 (6), p.1373-1386
Hauptverfasser:	Lama, Dilraj, Verma, Chandra S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Attenuation Binding Computer simulation eIF4E electrostatics Eukaryotic Initiation Factor-4E - chemistry Eukaryotic Initiation Factor-4E - metabolism Humans Initiation factor eIF-4E Kinases Lysine Models, Molecular molecular dynamics simulations Molecular modelling mRNA mRNA‐cap analogs Phosphates Phosphorylation Protein Conformation Recognition Residues RNA Caps - chemistry RNA Caps - metabolism Substrate Specificity Translation initiation
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