Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded

Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, mol...

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Veröffentlicht in:Pathology 2020-02, Vol.52 (2), p.192-196
Hauptverfasser: Samaratunga, Hemamali, Delahunt, Brett, Egevad, Lars, Srigley, John R., Billis, Athanase, Bostwick, David G., Camparo, Philippe, Cheng, Liang, Clouston, David, Denham, James, Furusato, Bungo, Hartmann, Arndt, Jufe, Laura, Kench, James, Kenwright, Diane N., Kristiansen, Glen, Leite, Katia R.M., MacLennan, Gregory T., Merrimen, Jennifer, Moch, Holger, Oxley, Jon, Pan, Chin-Chen, Paner, Gladell, Ro, Jae, Sesterhenn, Isabell A.M., Shanks, Jonathan, Thunders, Michelle, Tsuzuki, Toyonori, Wheeler, Thomas, Yaxley, John W., Varma, Murali
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container_end_page 196
container_issue 2
container_start_page 192
container_title Pathology
container_volume 52
creator Samaratunga, Hemamali
Delahunt, Brett
Egevad, Lars
Srigley, John R.
Billis, Athanase
Bostwick, David G.
Camparo, Philippe
Cheng, Liang
Clouston, David
Denham, James
Furusato, Bungo
Hartmann, Arndt
Jufe, Laura
Kench, James
Kenwright, Diane N.
Kristiansen, Glen
Leite, Katia R.M.
MacLennan, Gregory T.
Merrimen, Jennifer
Moch, Holger
Oxley, Jon
Pan, Chin-Chen
Paner, Gladell
Ro, Jae
Sesterhenn, Isabell A.M.
Shanks, Jonathan
Thunders, Michelle
Tsuzuki, Toyonori
Wheeler, Thomas
Yaxley, John W.
Varma, Murali
description Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.
doi_str_mv 10.1016/j.pathol.2019.11.001
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ISUP grade
prognosis
Prostate adenocarcinoma
title Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded
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