CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance

The use of taxanes has for decades been crucial for treatment of several cancers. A major limitation of these therapies is inherent or acquired drug resistance. A key to improved outcome of taxane-based therapies is to develop tools to predict and monitor drug efficacy and resistance in the clinical...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.19384-17, Article 19384
Hauptverfasser:	Langebäck, Anette, Bacanu, Smaranda, Laursen, Henriette, Mout, Lisanne, Seki, Takahiro, Erkens-Schulze, Sigrun, Ramos, Anderson Daniel, Berggren, Anna, Cao, Yihai, Hartman, Johan, van Weerden, Wytske, Bergh, Jonas, Nordlund, Pär, Lööf, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 631/67/1347 631/67/1857 82 Animal models Biomarkers, Tumor - genetics Biopsy, Fine-Needle - methods Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Line, Tumor Dose-Response Relationship, Drug Drug dosages Drug efficacy Drug resistance Drug Resistance, Neoplasm Female Heterografts Humanities and Social Sciences Humans Male MCF-7 Cells Medicin och hälsovetenskap multidisciplinary Prognosis Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Science Science (multidisciplinary) Taxanes Taxoids - adverse effects Taxoids - pharmacology Tubulin - genetics Xenografts
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