Increased Burden of Common Risk Alleles in Children With a Significant Fracture History

ABSTRACT Extreme presentations of common disease in children are often presumed to be of Mendelian etiology, but their polygenic basis has not been fully explored. We tested whether children with significant fracture history and no osteogenesis imperfecta (OI) are at increased polygenic risk for fra...

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Veröffentlicht in:	Journal of bone and mineral research 2020-05, Vol.35 (5), p.875-882
Hauptverfasser:	Manousaki, Despoina, Kämpe, Anders, Forgetta, Vincenzo, Makitie, Riikka E, Bardai, Ghalib, Belisle, Alexandre, Li, Rui, Andersson, Sture, Makitie, Outi, Rauch, Frank, Richards, J Brent
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biobanks Bone Density - genetics Bone mineral density Canada Child Children Dual energy X-ray absorptiometry Etiology FRACTURE RISK ASSESSMENT Fractures Humans Long bone Lumbar Vertebrae Multifactorial Inheritance Osteogenesis OSTEOGENESIS IMPERFECTA Osteogenesis Imperfecta - diagnostic imaging Osteogenesis Imperfecta - genetics Osteoporosis Osteoporotic Fractures - genetics POLYGENIC FRACTURE RISK Risk Factors Spine (lumbar) Trauma Ultrasound Vertebrae
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