CD137 negatively affects “browning” of white adipose tissue during cold exposure
Prolonged cold exposure stimulates the formation of brownlike adipocytes expressing UCP1 (uncoupling-protein-1) in subcutaneous white adipose tissue which, together with classical brown adipose tissue, contributes to maintaining body temperature in mammals through nonshivering thermogenesis. The mec...
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| Veröffentlicht in: | The Journal of biological chemistry 2020-02, Vol.295 (7), p.2034-2042 |
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| container_title | The Journal of biological chemistry |
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| creator | Srivastava, Raj Kamal Moliner, Annalena Lee, Ee-Soo Nickles, Emily Sim, Eunice Liu, Chang Schwarz, Herbert Ibáñez, Carlos F. |
| description | Prolonged cold exposure stimulates the formation of brownlike adipocytes expressing UCP1 (uncoupling-protein-1) in subcutaneous white adipose tissue which, together with classical brown adipose tissue, contributes to maintaining body temperature in mammals through nonshivering thermogenesis. The mechanisms that regulate the formation of these cells, alternatively called beige or brite adipocytes, are incompletely understood. Here we report that mice lacking CD137, a cell surface protein used in several studies as a marker for beige adipocytes, showed elevated levels of thermogenic markers, including UCP1, increased numbers of beige adipocyte precursors, and expanded UCP1-expressing cell clusters in inguinal white adipose tissue after chronic cold exposure. CD137 knockout mice also showed enhanced cold resistance. These results indicate that CD137 functions as a negative regulator of “browning” in white adipose tissue and call into question the use of this protein as a functional marker for beige adipocytes. |
| doi_str_mv | 10.1074/jbc.AC119.011795 |
| format | Article |
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The mechanisms that regulate the formation of these cells, alternatively called beige or brite adipocytes, are incompletely understood. Here we report that mice lacking CD137, a cell surface protein used in several studies as a marker for beige adipocytes, showed elevated levels of thermogenic markers, including UCP1, increased numbers of beige adipocyte precursors, and expanded UCP1-expressing cell clusters in inguinal white adipose tissue after chronic cold exposure. CD137 knockout mice also showed enhanced cold resistance. These results indicate that CD137 functions as a negative regulator of “browning” in white adipose tissue and call into question the use of this protein as a functional marker for beige adipocytes.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1074/jbc.AC119.011795</identifier><identifier>PMID: 31919095</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>adipocyte ; Adipocytes, Beige - metabolism ; adipogenesis ; adipokine ; adipose tissue ; adipose tissue metabolism ; Adipose Tissue, Brown - metabolism ; Adipose Tissue, White - metabolism ; Animals ; beige adipocyte ; Body Temperature - genetics ; brite adipocyte ; Cold Temperature ; Gene Expression Regulation - genetics ; Humans ; Metabolism ; Mice ; Mice, Knockout ; thermogenesis ; Thermogenesis - genetics ; Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics ; UCP1 ; Uncoupling Protein 1 - genetics</subject><ispartof>The Journal of biological chemistry, 2020-02, Vol.295 (7), p.2034-2042</ispartof><rights>2020 © 2020 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.</rights><rights>2020 Srivastava et al.</rights><rights>2020 Srivastava et al. 2020 Srivastava et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-6e4cae1576b0cefd35c4e501bd5156506638852938df8e0c53f7a4385dd71f6a3</citedby><cites>FETCH-LOGICAL-c551t-6e4cae1576b0cefd35c4e501bd5156506638852938df8e0c53f7a4385dd71f6a3</cites><orcidid>0000-0002-3558-3424 ; 0000-0002-0955-8807</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029117/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029117/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,552,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31919095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:143127592$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Srivastava, Raj Kamal</creatorcontrib><creatorcontrib>Moliner, Annalena</creatorcontrib><creatorcontrib>Lee, Ee-Soo</creatorcontrib><creatorcontrib>Nickles, Emily</creatorcontrib><creatorcontrib>Sim, Eunice</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><creatorcontrib>Schwarz, Herbert</creatorcontrib><creatorcontrib>Ibáñez, Carlos F.</creatorcontrib><title>CD137 negatively affects “browning” of white adipose tissue during cold exposure</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>Prolonged cold exposure stimulates the formation of brownlike adipocytes expressing UCP1 (uncoupling-protein-1) in subcutaneous white adipose tissue which, together with classical brown adipose tissue, contributes to maintaining body temperature in mammals through nonshivering thermogenesis. The mechanisms that regulate the formation of these cells, alternatively called beige or brite adipocytes, are incompletely understood. Here we report that mice lacking CD137, a cell surface protein used in several studies as a marker for beige adipocytes, showed elevated levels of thermogenic markers, including UCP1, increased numbers of beige adipocyte precursors, and expanded UCP1-expressing cell clusters in inguinal white adipose tissue after chronic cold exposure. CD137 knockout mice also showed enhanced cold resistance. 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| source | MEDLINE; SWEPUB Freely available online; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | adipocyte Adipocytes, Beige - metabolism adipogenesis adipokine adipose tissue adipose tissue metabolism Adipose Tissue, Brown - metabolism Adipose Tissue, White - metabolism Animals beige adipocyte Body Temperature - genetics brite adipocyte Cold Temperature Gene Expression Regulation - genetics Humans Metabolism Mice Mice, Knockout thermogenesis Thermogenesis - genetics Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics UCP1 Uncoupling Protein 1 - genetics |
| title | CD137 negatively affects “browning” of white adipose tissue during cold exposure |
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