The Number of Signaling Pathways Altered by Driver Mutations in Chronic Lymphocytic Leukemia Impacts Disease Outcome

Investigation of signaling pathways altered by recurrent gene mutations and their clinical impact in a consecutive cohort of patients with newly diagnosed chronic lymphocytic leukemia (CLL). The heterogeneous clinical course and genetic complexity of CLL warrant improved molecular prognostication. H...

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Veröffentlicht in:	Clinical cancer research 2020-03, Vol.26 (6), p.1507-1515
Hauptverfasser:	Brieghel, Christian, da Cunha-Bang, Caspar, Yde, Christina Westmose, Schmidt, Ane Yde, Kinalis, Savvas, Nadeu, Ferran, Andersen, Michael Asger, Jacobsen, Line Offenbach, Andersen, Mette Klarskov, Pedersen, Lone Bredo, Delgado, Julio, Baumann, Tycho, Mattsson, Mattias, Mansouri, Larry, Rosenquist, Richard, Campo, Elias, Nielsen, Finn Cilius, Niemann, Carsten Utoft
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Computational Biology - methods Databases, Genetic - statistics & numerical data Genes, Neoplasm High-Throughput Nucleotide Sequencing - methods Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemia, Lymphocytic, Chronic, B-Cell - pathology Medicin och hälsovetenskap Mutation Prognosis Prospective Studies Signal Transduction Survival Rate
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