Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
Among patients with severe antineutrophil cytoplasmic antibody–associated vasculitis, plasma exchange did not reduce the incidence of death or end-stage kidney disease. A reduced-dose regimen of oral glucocorticoids was noninferior to a standard-dose regimen with respect to death or ESKD.
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2020-02, Vol.382 (7), p.622-631 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 631 |
|---|---|
| container_issue | 7 |
| container_start_page | 622 |
| container_title | The New England journal of medicine |
| container_volume | 382 |
| creator | Walsh, Michael Merkel, Peter A Peh, Chen-Au Szpirt, Wladimir M Puéchal, Xavier Fujimoto, Shouichi Hawley, Carmel M Khalidi, Nader Floßmann, Oliver Wald, Ron Girard, Louis P Levin, Adeera Gregorini, Gina Harper, Lorraine Clark, William F Pagnoux, Christian Specks, Ulrich Smyth, Lucy Tesar, Vladimir Ito-Ihara, Toshiko de Zoysa, Janak Rashme Szczeklik, Wojciech Flores-Suárez, Luis Felipe Carette, Simon Guillevin, Loïc Pusey, Charles D Casian, Alina L Brezina, Biljana Mazzetti, Andrea McAlear, Carol A Broadhurst, Elizabeth Reidlinger, Donna Mehta, Samir Ives, Natalie Jayne, David R.W |
| description | Among patients with severe antineutrophil cytoplasmic antibody–associated vasculitis, plasma exchange did not reduce the incidence of death or end-stage kidney disease. A reduced-dose regimen of oral glucocorticoids was noninferior to a standard-dose regimen with respect to death or ESKD. |
| doi_str_mv | 10.1056/NEJMoa1803537 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_473498</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2354258644</sourcerecordid><originalsourceid>FETCH-LOGICAL-c583t-a865e929ce913c69faa33650fc2d8d8337e4db604ed83aa2d56f4d47894bbe5b3</originalsourceid><addsrcrecordid>eNp1kU2P0zAQhi0EYsvCkSuKhDhwCPg79gUpqsoWVBYkPq6W40y2Lkm82EmBf49XLQtFwhd7Zp55rZkXoccEvyBYyJeXq7fvgiUKM8GqO2hBBGMl51jeRQuMqSp5pdkZepDSDudDuL6PzhjFglGtFmj9obdpsMXqh9va8QoKO7bFRT-74EKcvAu-TYUfi4-whwhFfbmsyzql4LydoC2-2OTm3k8-PUT3OtsneHS8z9Hn16tPy3W5eX_xZllvSicUm0qrpABNtQNNmJO6s5YxKXDnaKtaxVgFvG0k5pADa2krZMdbXinNmwZEw85RedBN3-F6bsx19IONP02w3hxTX_MLDK8Y1yrzrw58rgzQOhinaPuTttPK6LfmKuxNxaioqMwCzw8C23_a1vXG3OTy5gmXldiTzD49fhbDtxnSZHZhjmPeh6FMcCqU5PzPCC6GlCJ0t7IEmxtTzYmpmX_y9wi39G8XM_DsAAxDMiPshv8I_QJxRqiD</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2354258644</pqid></control><display><type>article</type><title>Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SWEPUB Freely available online</source><source>New England Journal of Medicine</source><creator>Walsh, Michael ; Merkel, Peter A ; Peh, Chen-Au ; Szpirt, Wladimir M ; Puéchal, Xavier ; Fujimoto, Shouichi ; Hawley, Carmel M ; Khalidi, Nader ; Floßmann, Oliver ; Wald, Ron ; Girard, Louis P ; Levin, Adeera ; Gregorini, Gina ; Harper, Lorraine ; Clark, William F ; Pagnoux, Christian ; Specks, Ulrich ; Smyth, Lucy ; Tesar, Vladimir ; Ito-Ihara, Toshiko ; de Zoysa, Janak Rashme ; Szczeklik, Wojciech ; Flores-Suárez, Luis Felipe ; Carette, Simon ; Guillevin, Loïc ; Pusey, Charles D ; Casian, Alina L ; Brezina, Biljana ; Mazzetti, Andrea ; McAlear, Carol A ; Broadhurst, Elizabeth ; Reidlinger, Donna ; Mehta, Samir ; Ives, Natalie ; Jayne, David R.W</creator><creatorcontrib>Walsh, Michael ; Merkel, Peter A ; Peh, Chen-Au ; Szpirt, Wladimir M ; Puéchal, Xavier ; Fujimoto, Shouichi ; Hawley, Carmel M ; Khalidi, Nader ; Floßmann, Oliver ; Wald, Ron ; Girard, Louis P ; Levin, Adeera ; Gregorini, Gina ; Harper, Lorraine ; Clark, William F ; Pagnoux, Christian ; Specks, Ulrich ; Smyth, Lucy ; Tesar, Vladimir ; Ito-Ihara, Toshiko ; de Zoysa, Janak Rashme ; Szczeklik, Wojciech ; Flores-Suárez, Luis Felipe ; Carette, Simon ; Guillevin, Loïc ; Pusey, Charles D ; Casian, Alina L ; Brezina, Biljana ; Mazzetti, Andrea ; McAlear, Carol A ; Broadhurst, Elizabeth ; Reidlinger, Donna ; Mehta, Samir ; Ives, Natalie ; Jayne, David R.W ; PEXIVAS Investigators</creatorcontrib><description>Among patients with severe antineutrophil cytoplasmic antibody–associated vasculitis, plasma exchange did not reduce the incidence of death or end-stage kidney disease. A reduced-dose regimen of oral glucocorticoids was noninferior to a standard-dose regimen with respect to death or ESKD.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1803537</identifier><identifier>PMID: 32053298</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Administration, Oral ; Adult ; Aged ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - mortality ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - therapy ; Antineutrophil cytoplasmic antibodies ; Apheresis ; Clinical trials ; Combined Modality Therapy ; Cyclophosphamide ; Cyclophosphamide - therapeutic use ; Death ; Dose-Response Relationship, Drug ; End-stage renal disease ; Female ; Glomerular filtration rate ; Glucocorticoids ; Glucocorticoids - administration & dosage ; Glucocorticoids - adverse effects ; Hemorrhage ; Human health and pathology ; Humans ; Immunosuppressive Agents ; Immunosuppressive Agents - therapeutic use ; Incidence ; Induction Chemotherapy ; Kidney Diseases ; Kidney Diseases - complications ; Kidney Failure, Chronic ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - prevention & control ; Life Sciences ; Male ; Middle Aged ; Patients ; Plasma ; Plasma Exchange ; Plasma Exchange - adverse effects ; Quality of life ; Rituximab ; Rituximab - therapeutic use ; Statistical analysis ; Urology and Nephrology ; Vasculitis</subject><ispartof>The New England journal of medicine, 2020-02, Vol.382 (7), p.622-631</ispartof><rights>Copyright © 2020 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2020 Massachusetts Medical Society.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-a865e929ce913c69faa33650fc2d8d8337e4db604ed83aa2d56f4d47894bbe5b3</citedby><cites>FETCH-LOGICAL-c583t-a865e929ce913c69faa33650fc2d8d8337e4db604ed83aa2d56f4d47894bbe5b3</cites><orcidid>0000-0002-8270-2617 ; 0000-0001-5976-3609 ; 0000-0002-0172-8023 ; 0000-0003-3573-9203 ; 0000-0002-3365-9923 ; 0000-0001-6463-2160 ; 0000-0002-1349-1123</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1803537$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1803537$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32053298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.umontpellier.fr/hal-03514675$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:143057859$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Walsh, Michael</creatorcontrib><creatorcontrib>Merkel, Peter A</creatorcontrib><creatorcontrib>Peh, Chen-Au</creatorcontrib><creatorcontrib>Szpirt, Wladimir M</creatorcontrib><creatorcontrib>Puéchal, Xavier</creatorcontrib><creatorcontrib>Fujimoto, Shouichi</creatorcontrib><creatorcontrib>Hawley, Carmel M</creatorcontrib><creatorcontrib>Khalidi, Nader</creatorcontrib><creatorcontrib>Floßmann, Oliver</creatorcontrib><creatorcontrib>Wald, Ron</creatorcontrib><creatorcontrib>Girard, Louis P</creatorcontrib><creatorcontrib>Levin, Adeera</creatorcontrib><creatorcontrib>Gregorini, Gina</creatorcontrib><creatorcontrib>Harper, Lorraine</creatorcontrib><creatorcontrib>Clark, William F</creatorcontrib><creatorcontrib>Pagnoux, Christian</creatorcontrib><creatorcontrib>Specks, Ulrich</creatorcontrib><creatorcontrib>Smyth, Lucy</creatorcontrib><creatorcontrib>Tesar, Vladimir</creatorcontrib><creatorcontrib>Ito-Ihara, Toshiko</creatorcontrib><creatorcontrib>de Zoysa, Janak Rashme</creatorcontrib><creatorcontrib>Szczeklik, Wojciech</creatorcontrib><creatorcontrib>Flores-Suárez, Luis Felipe</creatorcontrib><creatorcontrib>Carette, Simon</creatorcontrib><creatorcontrib>Guillevin, Loïc</creatorcontrib><creatorcontrib>Pusey, Charles D</creatorcontrib><creatorcontrib>Casian, Alina L</creatorcontrib><creatorcontrib>Brezina, Biljana</creatorcontrib><creatorcontrib>Mazzetti, Andrea</creatorcontrib><creatorcontrib>McAlear, Carol A</creatorcontrib><creatorcontrib>Broadhurst, Elizabeth</creatorcontrib><creatorcontrib>Reidlinger, Donna</creatorcontrib><creatorcontrib>Mehta, Samir</creatorcontrib><creatorcontrib>Ives, Natalie</creatorcontrib><creatorcontrib>Jayne, David R.W</creatorcontrib><creatorcontrib>PEXIVAS Investigators</creatorcontrib><title>Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Among patients with severe antineutrophil cytoplasmic antibody–associated vasculitis, plasma exchange did not reduce the incidence of death or end-stage kidney disease. A reduced-dose regimen of oral glucocorticoids was noninferior to a standard-dose regimen with respect to death or ESKD.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - mortality</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - therapy</subject><subject>Antineutrophil cytoplasmic antibodies</subject><subject>Apheresis</subject><subject>Clinical trials</subject><subject>Combined Modality Therapy</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Death</subject><subject>Dose-Response Relationship, Drug</subject><subject>End-stage renal disease</subject><subject>Female</subject><subject>Glomerular filtration rate</subject><subject>Glucocorticoids</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Glucocorticoids - adverse effects</subject><subject>Hemorrhage</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Immunosuppressive Agents</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Incidence</subject><subject>Induction Chemotherapy</subject><subject>Kidney Diseases</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Failure, Chronic</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - prevention & control</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Plasma</subject><subject>Plasma Exchange</subject><subject>Plasma Exchange - adverse effects</subject><subject>Quality of life</subject><subject>Rituximab</subject><subject>Rituximab - therapeutic use</subject><subject>Statistical analysis</subject><subject>Urology and Nephrology</subject><subject>Vasculitis</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>D8T</sourceid><recordid>eNp1kU2P0zAQhi0EYsvCkSuKhDhwCPg79gUpqsoWVBYkPq6W40y2Lkm82EmBf49XLQtFwhd7Zp55rZkXoccEvyBYyJeXq7fvgiUKM8GqO2hBBGMl51jeRQuMqSp5pdkZepDSDudDuL6PzhjFglGtFmj9obdpsMXqh9va8QoKO7bFRT-74EKcvAu-TYUfi4-whwhFfbmsyzql4LydoC2-2OTm3k8-PUT3OtsneHS8z9Hn16tPy3W5eX_xZllvSicUm0qrpABNtQNNmJO6s5YxKXDnaKtaxVgFvG0k5pADa2krZMdbXinNmwZEw85RedBN3-F6bsx19IONP02w3hxTX_MLDK8Y1yrzrw58rgzQOhinaPuTttPK6LfmKuxNxaioqMwCzw8C23_a1vXG3OTy5gmXldiTzD49fhbDtxnSZHZhjmPeh6FMcCqU5PzPCC6GlCJ0t7IEmxtTzYmpmX_y9wi39G8XM_DsAAxDMiPshv8I_QJxRqiD</recordid><startdate>20200213</startdate><enddate>20200213</enddate><creator>Walsh, Michael</creator><creator>Merkel, Peter A</creator><creator>Peh, Chen-Au</creator><creator>Szpirt, Wladimir M</creator><creator>Puéchal, Xavier</creator><creator>Fujimoto, Shouichi</creator><creator>Hawley, Carmel M</creator><creator>Khalidi, Nader</creator><creator>Floßmann, Oliver</creator><creator>Wald, Ron</creator><creator>Girard, Louis P</creator><creator>Levin, Adeera</creator><creator>Gregorini, Gina</creator><creator>Harper, Lorraine</creator><creator>Clark, William F</creator><creator>Pagnoux, Christian</creator><creator>Specks, Ulrich</creator><creator>Smyth, Lucy</creator><creator>Tesar, Vladimir</creator><creator>Ito-Ihara, Toshiko</creator><creator>de Zoysa, Janak Rashme</creator><creator>Szczeklik, Wojciech</creator><creator>Flores-Suárez, Luis Felipe</creator><creator>Carette, Simon</creator><creator>Guillevin, Loïc</creator><creator>Pusey, Charles D</creator><creator>Casian, Alina L</creator><creator>Brezina, Biljana</creator><creator>Mazzetti, Andrea</creator><creator>McAlear, Carol A</creator><creator>Broadhurst, Elizabeth</creator><creator>Reidlinger, Donna</creator><creator>Mehta, Samir</creator><creator>Ives, Natalie</creator><creator>Jayne, David R.W</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>1XC</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-8270-2617</orcidid><orcidid>https://orcid.org/0000-0001-5976-3609</orcidid><orcidid>https://orcid.org/0000-0002-0172-8023</orcidid><orcidid>https://orcid.org/0000-0003-3573-9203</orcidid><orcidid>https://orcid.org/0000-0002-3365-9923</orcidid><orcidid>https://orcid.org/0000-0001-6463-2160</orcidid><orcidid>https://orcid.org/0000-0002-1349-1123</orcidid></search><sort><creationdate>20200213</creationdate><title>Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis</title><author>Walsh, Michael ; Merkel, Peter A ; Peh, Chen-Au ; Szpirt, Wladimir M ; Puéchal, Xavier ; Fujimoto, Shouichi ; Hawley, Carmel M ; Khalidi, Nader ; Floßmann, Oliver ; Wald, Ron ; Girard, Louis P ; Levin, Adeera ; Gregorini, Gina ; Harper, Lorraine ; Clark, William F ; Pagnoux, Christian ; Specks, Ulrich ; Smyth, Lucy ; Tesar, Vladimir ; Ito-Ihara, Toshiko ; de Zoysa, Janak Rashme ; Szczeklik, Wojciech ; Flores-Suárez, Luis Felipe ; Carette, Simon ; Guillevin, Loïc ; Pusey, Charles D ; Casian, Alina L ; Brezina, Biljana ; Mazzetti, Andrea ; McAlear, Carol A ; Broadhurst, Elizabeth ; Reidlinger, Donna ; Mehta, Samir ; Ives, Natalie ; Jayne, David R.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-a865e929ce913c69faa33650fc2d8d8337e4db604ed83aa2d56f4d47894bbe5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - mortality</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - therapy</topic><topic>Antineutrophil cytoplasmic antibodies</topic><topic>Apheresis</topic><topic>Clinical trials</topic><topic>Combined Modality Therapy</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>Death</topic><topic>Dose-Response Relationship, Drug</topic><topic>End-stage renal disease</topic><topic>Female</topic><topic>Glomerular filtration rate</topic><topic>Glucocorticoids</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Glucocorticoids - adverse effects</topic><topic>Hemorrhage</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Immunosuppressive Agents</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Incidence</topic><topic>Induction Chemotherapy</topic><topic>Kidney Diseases</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Failure, Chronic</topic><topic>Kidney Failure, Chronic - epidemiology</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - prevention & control</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Plasma</topic><topic>Plasma Exchange</topic><topic>Plasma Exchange - adverse effects</topic><topic>Quality of life</topic><topic>Rituximab</topic><topic>Rituximab - therapeutic use</topic><topic>Statistical analysis</topic><topic>Urology and Nephrology</topic><topic>Vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walsh, Michael</creatorcontrib><creatorcontrib>Merkel, Peter A</creatorcontrib><creatorcontrib>Peh, Chen-Au</creatorcontrib><creatorcontrib>Szpirt, Wladimir M</creatorcontrib><creatorcontrib>Puéchal, Xavier</creatorcontrib><creatorcontrib>Fujimoto, Shouichi</creatorcontrib><creatorcontrib>Hawley, Carmel M</creatorcontrib><creatorcontrib>Khalidi, Nader</creatorcontrib><creatorcontrib>Floßmann, Oliver</creatorcontrib><creatorcontrib>Wald, Ron</creatorcontrib><creatorcontrib>Girard, Louis P</creatorcontrib><creatorcontrib>Levin, Adeera</creatorcontrib><creatorcontrib>Gregorini, Gina</creatorcontrib><creatorcontrib>Harper, Lorraine</creatorcontrib><creatorcontrib>Clark, William F</creatorcontrib><creatorcontrib>Pagnoux, Christian</creatorcontrib><creatorcontrib>Specks, Ulrich</creatorcontrib><creatorcontrib>Smyth, Lucy</creatorcontrib><creatorcontrib>Tesar, Vladimir</creatorcontrib><creatorcontrib>Ito-Ihara, Toshiko</creatorcontrib><creatorcontrib>de Zoysa, Janak Rashme</creatorcontrib><creatorcontrib>Szczeklik, Wojciech</creatorcontrib><creatorcontrib>Flores-Suárez, Luis Felipe</creatorcontrib><creatorcontrib>Carette, Simon</creatorcontrib><creatorcontrib>Guillevin, Loïc</creatorcontrib><creatorcontrib>Pusey, Charles D</creatorcontrib><creatorcontrib>Casian, Alina L</creatorcontrib><creatorcontrib>Brezina, Biljana</creatorcontrib><creatorcontrib>Mazzetti, Andrea</creatorcontrib><creatorcontrib>McAlear, Carol A</creatorcontrib><creatorcontrib>Broadhurst, Elizabeth</creatorcontrib><creatorcontrib>Reidlinger, Donna</creatorcontrib><creatorcontrib>Mehta, Samir</creatorcontrib><creatorcontrib>Ives, Natalie</creatorcontrib><creatorcontrib>Jayne, David R.W</creatorcontrib><creatorcontrib>PEXIVAS Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walsh, Michael</au><au>Merkel, Peter A</au><au>Peh, Chen-Au</au><au>Szpirt, Wladimir M</au><au>Puéchal, Xavier</au><au>Fujimoto, Shouichi</au><au>Hawley, Carmel M</au><au>Khalidi, Nader</au><au>Floßmann, Oliver</au><au>Wald, Ron</au><au>Girard, Louis P</au><au>Levin, Adeera</au><au>Gregorini, Gina</au><au>Harper, Lorraine</au><au>Clark, William F</au><au>Pagnoux, Christian</au><au>Specks, Ulrich</au><au>Smyth, Lucy</au><au>Tesar, Vladimir</au><au>Ito-Ihara, Toshiko</au><au>de Zoysa, Janak Rashme</au><au>Szczeklik, Wojciech</au><au>Flores-Suárez, Luis Felipe</au><au>Carette, Simon</au><au>Guillevin, Loïc</au><au>Pusey, Charles D</au><au>Casian, Alina L</au><au>Brezina, Biljana</au><au>Mazzetti, Andrea</au><au>McAlear, Carol A</au><au>Broadhurst, Elizabeth</au><au>Reidlinger, Donna</au><au>Mehta, Samir</au><au>Ives, Natalie</au><au>Jayne, David R.W</au><aucorp>PEXIVAS Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2020-02-13</date><risdate>2020</risdate><volume>382</volume><issue>7</issue><spage>622</spage><epage>631</epage><pages>622-631</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Among patients with severe antineutrophil cytoplasmic antibody–associated vasculitis, plasma exchange did not reduce the incidence of death or end-stage kidney disease. A reduced-dose regimen of oral glucocorticoids was noninferior to a standard-dose regimen with respect to death or ESKD.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>32053298</pmid><doi>10.1056/NEJMoa1803537</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8270-2617</orcidid><orcidid>https://orcid.org/0000-0001-5976-3609</orcidid><orcidid>https://orcid.org/0000-0002-0172-8023</orcidid><orcidid>https://orcid.org/0000-0003-3573-9203</orcidid><orcidid>https://orcid.org/0000-0002-3365-9923</orcidid><orcidid>https://orcid.org/0000-0001-6463-2160</orcidid><orcidid>https://orcid.org/0000-0002-1349-1123</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2020-02, Vol.382 (7), p.622-631 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_473498 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; New England Journal of Medicine |
| subjects | Administration, Oral Adult Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - mortality Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - therapy Antineutrophil cytoplasmic antibodies Apheresis Clinical trials Combined Modality Therapy Cyclophosphamide Cyclophosphamide - therapeutic use Death Dose-Response Relationship, Drug End-stage renal disease Female Glomerular filtration rate Glucocorticoids Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Hemorrhage Human health and pathology Humans Immunosuppressive Agents Immunosuppressive Agents - therapeutic use Incidence Induction Chemotherapy Kidney Diseases Kidney Diseases - complications Kidney Failure, Chronic Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - etiology Kidney Failure, Chronic - prevention & control Life Sciences Male Middle Aged Patients Plasma Plasma Exchange Plasma Exchange - adverse effects Quality of life Rituximab Rituximab - therapeutic use Statistical analysis Urology and Nephrology Vasculitis |
| title | Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A41%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20Exchange%20and%20Glucocorticoids%20in%20Severe%20ANCA-Associated%20Vasculitis&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Walsh,%20Michael&rft.aucorp=PEXIVAS%20Investigators&rft.date=2020-02-13&rft.volume=382&rft.issue=7&rft.spage=622&rft.epage=631&rft.pages=622-631&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMoa1803537&rft_dat=%3Cproquest_swepu%3E2354258644%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2354258644&rft_id=info:pmid/32053298&rfr_iscdi=true |