Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies
Eating disorders and substance use disorders frequently co‐occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin‐based =...
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| Veröffentlicht in: | Addiction biology 2021-01, Vol.26 (1), p.e12880-n/a |
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| creator | Baker, Jessica H. Gordon, Scott Mattheisen, Manuel Ripke, Stephan Yao, Shuyang Adan, Roger A.H. Boraska Perica, Vesna Cichon, Sven Cone, Roger D. DeSocio, Janiece E. Docampo, Elisa Escaramís, Geòrgia Esko, Tõnu Favaro, Angela Fischer, Krista Föcker, Manuel Gonidakis, Fragiskos Guillaume, Sébastien Guo, Yiran Hakonarson, Hakon Hebebrand, Johannes Helder, Sietske G. Herms, Stefan Herzog, Wolfgang Huckins, Laura M. Hudson, James I. Karhunen, Leila Karwautz, Andreas Kennedy, James L. Klump, Kelly L. Le Hellard, Stephanie Lin, Bochao Danae Meulenbelt, Ingrid Mitchell, Karen Monteleone, Alessio Maria Nacmias, Benedetta Ophoff, Roel A. Padyukov, Leonid Palotie, Aarno Pinto, Dalila Ricca, Valdo Ritschel, Franziska Santonastaso, Paolo Scherag, André Seitz, Jochen Slachtova, Lenka Slof‐Op't Landt, Margarita C.T. Slopien, Agnieszka Szatkiewicz, Jin P. Wagner, Gudrun Walton, Esther Widen, Elisabeth Crawford, Steven Johnson, Craig Mitchell, James Whiteman, David C. Birgegård, Andreas Norring, Claes Polimanti, Renato Clarke, Toni‐Kim Degenhardt, Franziska Docherty, Anna R. Foo, Jerome C. Fox, Louis Frank, Josef Hack, Laura M. Lahti, Jari Lahti‐Pulkkinen, Marius Loukola, Anu Palviainen, Teemu Saccone, Nancy L. Salvatore, Jessica E. Strohmaier, Jana Wang, Jen‐Chyong Wills, Amanda G. Boardman, Jason D. Choi, Doo‐Sup Culverhouse, Robert C. Dahmen, Norbert Domingue, Benjamin W. Gäebel, Wolfgang Ising, Marcus Keyes, Margaret Lucae, Susanne Nurnberger, John I. Preuss, Ulrich Bierut, Laura J. Brown, Sandra A. Costello, E. Jane Eriksson, Johan G. Foroud, Tatiana M. Hesselbrock, Victor Johnson, Eric O. Stallings, Michael C. Vrieze, Scott Wade, Tracey D. Heath, Andrew C. Martin, Nicholas G. Breen, Gerome Bulik, Cynthia M. |
| description | Eating disorders and substance use disorders frequently co‐occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin‐based = 0.23‐0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome‐wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance‐use‐related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism‐based genetic correlations between eating disorder‐ and substance‐use‐related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co‐varying for major depressive disorder loci. The patterns of association between eating disorder‐ and substance‐use‐related phenotypes highlights the potentially complex and substance‐specific relationships among these behaviors.
Eating disorders and substance use disorders frequently co‐occur. Using genome‐wide association studies, we found differential patterns of genetic correlations between specific eating disorder‐ and substance‐use‐ related phenotypes. These patterns of association highlight the potentially complex and substance‐specific associations among eating disorder‐ and substance‐use‐related behaviors. |
| doi_str_mv | 10.1111/adb.12880 |
| format | Article |
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Jane ; Eriksson, Johan G. ; Foroud, Tatiana M. ; Hesselbrock, Victor ; Johnson, Eric O. ; Stallings, Michael C. ; Vrieze, Scott ; Wade, Tracey D. ; Heath, Andrew C. ; Martin, Nicholas G. ; Breen, Gerome ; Bulik, Cynthia M.</creator><creatorcontrib>Baker, Jessica H. ; Gordon, Scott ; Mattheisen, Manuel ; Ripke, Stephan ; Yao, Shuyang ; Adan, Roger A.H. ; Boraska Perica, Vesna ; Cichon, Sven ; Cone, Roger D. ; DeSocio, Janiece E. ; Docampo, Elisa ; Escaramís, Geòrgia ; Esko, Tõnu ; Favaro, Angela ; Fischer, Krista ; Föcker, Manuel ; Gonidakis, Fragiskos ; Guillaume, Sébastien ; Guo, Yiran ; Hakonarson, Hakon ; Hebebrand, Johannes ; Helder, Sietske G. ; Herms, Stefan ; Herzog, Wolfgang ; Huckins, Laura M. ; Hudson, James I. ; Karhunen, Leila ; Karwautz, Andreas ; Kennedy, James L. ; Klump, Kelly L. ; Le Hellard, Stephanie ; Lin, Bochao Danae ; Meulenbelt, Ingrid ; Mitchell, Karen ; Monteleone, Alessio Maria ; Nacmias, Benedetta ; Ophoff, Roel A. ; Padyukov, Leonid ; Palotie, Aarno ; Pinto, Dalila ; Ricca, Valdo ; Ritschel, Franziska ; Santonastaso, Paolo ; Scherag, André ; Seitz, Jochen ; Slachtova, Lenka ; Slof‐Op't Landt, Margarita C.T. ; Slopien, Agnieszka ; Szatkiewicz, Jin P. ; Wagner, Gudrun ; Walton, Esther ; Widen, Elisabeth ; Crawford, Steven ; Johnson, Craig ; Mitchell, James ; Whiteman, David C. ; Birgegård, Andreas ; Norring, Claes ; Polimanti, Renato ; Clarke, Toni‐Kim ; Degenhardt, Franziska ; Docherty, Anna R. ; Foo, Jerome C. ; Fox, Louis ; Frank, Josef ; Hack, Laura M. ; Lahti, Jari ; Lahti‐Pulkkinen, Marius ; Loukola, Anu ; Palviainen, Teemu ; Saccone, Nancy L. ; Salvatore, Jessica E. ; Strohmaier, Jana ; Wang, Jen‐Chyong ; Wills, Amanda G. ; Boardman, Jason D. ; Choi, Doo‐Sup ; Culverhouse, Robert C. ; Dahmen, Norbert ; Domingue, Benjamin W. ; Gäebel, Wolfgang ; Ising, Marcus ; Keyes, Margaret ; Lucae, Susanne ; Nurnberger, John I. ; Preuss, Ulrich ; Bierut, Laura J. ; Brown, Sandra A. ; Costello, E. Jane ; Eriksson, Johan G. ; Foroud, Tatiana M. ; Hesselbrock, Victor ; Johnson, Eric O. ; Stallings, Michael C. ; Vrieze, Scott ; Wade, Tracey D. ; Heath, Andrew C. ; Martin, Nicholas G. ; Breen, Gerome ; Bulik, Cynthia M.</creatorcontrib><description>Eating disorders and substance use disorders frequently co‐occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin‐based = 0.23‐0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome‐wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance‐use‐related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism‐based genetic correlations between eating disorder‐ and substance‐use‐related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co‐varying for major depressive disorder loci. The patterns of association between eating disorder‐ and substance‐use‐related phenotypes highlights the potentially complex and substance‐specific relationships among these behaviors.
Eating disorders and substance use disorders frequently co‐occur. Using genome‐wide association studies, we found differential patterns of genetic correlations between specific eating disorder‐ and substance‐use‐ related phenotypes. These patterns of association highlight the potentially complex and substance‐specific associations among eating disorder‐ and substance‐use‐related behaviors.</description><identifier>ISSN: 1355-6215</identifier><identifier>ISSN: 1369-1600</identifier><identifier>EISSN: 1369-1600</identifier><identifier>DOI: 10.1111/adb.12880</identifier><identifier>PMID: 32064741</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>alcohol dependence ; Alcohol use ; Alcoholic beverages ; Alcoholism - genetics ; Anorexia ; anorexia-nervosa ; Biochemistry & Molecular Biology ; Biochemistry and Molecular Biology ; Biokemi och molekylärbiologi ; Bulimia ; Bulimia nervosa ; Cannabis ; Cigarettes ; Cognitive science ; comorbidity ; contributions ; Depressive Disorder, Major - genetics ; Drug dependence ; Drug use ; Eating disorders ; endocannabinoids ; environmental ; Feeding and Eating Disorders - genetics ; Gene polymorphism ; genetic correlation ; Genetic diversity ; Genetics & genetic processes ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; gwas ; Génétique & processus génétiques ; Human health and pathology ; Humans ; Life Sciences ; Linkage Disequilibrium ; Marijuana ; Medicin och hälsovetenskap ; Mental disorders ; Neuroscience ; Phenotype ; Phenotypes ; Polymorphism, Single Nucleotide ; Psychiatrics and mental health ; Risk Factors ; Schizophrenia ; Schizophrenia - genetics ; Sciences du vivant ; Single-nucleotide polymorphism ; Smoking ; Substance Abuse ; substance use ; Substance-Related Disorders - genetics ; Tobacco Use Disorder - genetics ; twin ; Twins ; women</subject><ispartof>Addiction biology, 2021-01, Vol.26 (1), p.e12880-n/a</ispartof><rights>2020 Society for the Study of Addiction</rights><rights>2020 Society for the Study of Addiction.</rights><rights>2021 Society for the Study of Addiction</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6500-a5600f7fec09fce345aa646839298fc26e7c337223c949450ca9c971567ba37e3</citedby><cites>FETCH-LOGICAL-c6500-a5600f7fec09fce345aa646839298fc26e7c337223c949450ca9c971567ba37e3</cites><orcidid>0000-0001-9368-9457 ; 0000-0002-7722-7348 ; 0000-0001-8405-381X ; 0000-0002-6540-5194 ; 0000-0002-8870-1949 ; 0000-0002-4310-5297 ; 0000-0001-5790-7584 ; 0000-0002-9015-6281 ; 0000-0002-6519-8586 ; 0000-0002-1724-5405 ; 0000-0002-0719-101X ; 0000-0002-7315-7899 ; 0000-0002-2786-8200 ; 0000-0002-4496-6451 ; 0000-0003-1080-4339 ; 0000-0002-5236-6149 ; 0000-0002-6621-3493 ; 0000-0003-2814-7461 ; 0000-0002-6619-873X ; 0000-0002-8070-9938 ; 0000-0003-2053-1792 ; 0000-0003-4867-9465 ; 0000-0002-1876-6368 ; 0000-0002-6769-9982 ; 0000-0003-0871-4596 ; 0000-0002-0576-2472 ; 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Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Baker, Jessica H.</creatorcontrib><creatorcontrib>Gordon, Scott</creatorcontrib><creatorcontrib>Mattheisen, Manuel</creatorcontrib><creatorcontrib>Ripke, Stephan</creatorcontrib><creatorcontrib>Yao, Shuyang</creatorcontrib><creatorcontrib>Adan, Roger A.H.</creatorcontrib><creatorcontrib>Boraska Perica, Vesna</creatorcontrib><creatorcontrib>Cichon, Sven</creatorcontrib><creatorcontrib>Cone, Roger D.</creatorcontrib><creatorcontrib>DeSocio, Janiece E.</creatorcontrib><creatorcontrib>Docampo, Elisa</creatorcontrib><creatorcontrib>Escaramís, Geòrgia</creatorcontrib><creatorcontrib>Esko, Tõnu</creatorcontrib><creatorcontrib>Favaro, Angela</creatorcontrib><creatorcontrib>Fischer, Krista</creatorcontrib><creatorcontrib>Föcker, Manuel</creatorcontrib><creatorcontrib>Gonidakis, Fragiskos</creatorcontrib><creatorcontrib>Guillaume, Sébastien</creatorcontrib><creatorcontrib>Guo, Yiran</creatorcontrib><creatorcontrib>Hakonarson, Hakon</creatorcontrib><creatorcontrib>Hebebrand, Johannes</creatorcontrib><creatorcontrib>Helder, Sietske G.</creatorcontrib><creatorcontrib>Herms, Stefan</creatorcontrib><creatorcontrib>Herzog, Wolfgang</creatorcontrib><creatorcontrib>Huckins, Laura M.</creatorcontrib><creatorcontrib>Hudson, James I.</creatorcontrib><creatorcontrib>Karhunen, Leila</creatorcontrib><creatorcontrib>Karwautz, Andreas</creatorcontrib><creatorcontrib>Kennedy, James L.</creatorcontrib><creatorcontrib>Klump, Kelly L.</creatorcontrib><creatorcontrib>Le Hellard, Stephanie</creatorcontrib><creatorcontrib>Lin, Bochao Danae</creatorcontrib><creatorcontrib>Meulenbelt, Ingrid</creatorcontrib><creatorcontrib>Mitchell, Karen</creatorcontrib><creatorcontrib>Monteleone, Alessio Maria</creatorcontrib><creatorcontrib>Nacmias, Benedetta</creatorcontrib><creatorcontrib>Ophoff, Roel A.</creatorcontrib><creatorcontrib>Padyukov, Leonid</creatorcontrib><creatorcontrib>Palotie, Aarno</creatorcontrib><creatorcontrib>Pinto, Dalila</creatorcontrib><creatorcontrib>Ricca, Valdo</creatorcontrib><creatorcontrib>Ritschel, Franziska</creatorcontrib><creatorcontrib>Santonastaso, Paolo</creatorcontrib><creatorcontrib>Scherag, André</creatorcontrib><creatorcontrib>Seitz, Jochen</creatorcontrib><creatorcontrib>Slachtova, Lenka</creatorcontrib><creatorcontrib>Slof‐Op't Landt, Margarita C.T.</creatorcontrib><creatorcontrib>Slopien, Agnieszka</creatorcontrib><creatorcontrib>Szatkiewicz, Jin P.</creatorcontrib><creatorcontrib>Wagner, Gudrun</creatorcontrib><creatorcontrib>Walton, Esther</creatorcontrib><creatorcontrib>Widen, Elisabeth</creatorcontrib><creatorcontrib>Crawford, Steven</creatorcontrib><creatorcontrib>Johnson, Craig</creatorcontrib><creatorcontrib>Mitchell, James</creatorcontrib><creatorcontrib>Whiteman, David C.</creatorcontrib><creatorcontrib>Birgegård, Andreas</creatorcontrib><creatorcontrib>Norring, Claes</creatorcontrib><creatorcontrib>Polimanti, Renato</creatorcontrib><creatorcontrib>Clarke, Toni‐Kim</creatorcontrib><creatorcontrib>Degenhardt, Franziska</creatorcontrib><creatorcontrib>Docherty, Anna R.</creatorcontrib><creatorcontrib>Foo, Jerome C.</creatorcontrib><creatorcontrib>Fox, Louis</creatorcontrib><creatorcontrib>Frank, Josef</creatorcontrib><creatorcontrib>Hack, Laura M.</creatorcontrib><creatorcontrib>Lahti, Jari</creatorcontrib><creatorcontrib>Lahti‐Pulkkinen, Marius</creatorcontrib><creatorcontrib>Loukola, Anu</creatorcontrib><creatorcontrib>Palviainen, Teemu</creatorcontrib><creatorcontrib>Saccone, Nancy L.</creatorcontrib><creatorcontrib>Salvatore, Jessica E.</creatorcontrib><creatorcontrib>Strohmaier, Jana</creatorcontrib><creatorcontrib>Wang, Jen‐Chyong</creatorcontrib><creatorcontrib>Wills, Amanda G.</creatorcontrib><creatorcontrib>Boardman, Jason D.</creatorcontrib><creatorcontrib>Choi, Doo‐Sup</creatorcontrib><creatorcontrib>Culverhouse, Robert C.</creatorcontrib><creatorcontrib>Dahmen, Norbert</creatorcontrib><creatorcontrib>Domingue, Benjamin W.</creatorcontrib><creatorcontrib>Gäebel, Wolfgang</creatorcontrib><creatorcontrib>Ising, Marcus</creatorcontrib><creatorcontrib>Keyes, Margaret</creatorcontrib><creatorcontrib>Lucae, Susanne</creatorcontrib><creatorcontrib>Nurnberger, John I.</creatorcontrib><creatorcontrib>Preuss, Ulrich</creatorcontrib><creatorcontrib>Bierut, Laura J.</creatorcontrib><creatorcontrib>Brown, Sandra A.</creatorcontrib><creatorcontrib>Costello, E. Jane</creatorcontrib><creatorcontrib>Eriksson, Johan G.</creatorcontrib><creatorcontrib>Foroud, Tatiana M.</creatorcontrib><creatorcontrib>Hesselbrock, Victor</creatorcontrib><creatorcontrib>Johnson, Eric O.</creatorcontrib><creatorcontrib>Stallings, Michael C.</creatorcontrib><creatorcontrib>Vrieze, Scott</creatorcontrib><creatorcontrib>Wade, Tracey D.</creatorcontrib><creatorcontrib>Heath, Andrew C.</creatorcontrib><creatorcontrib>Martin, Nicholas G.</creatorcontrib><creatorcontrib>Breen, Gerome</creatorcontrib><creatorcontrib>Bulik, Cynthia M.</creatorcontrib><title>Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies</title><title>Addiction biology</title><addtitle>Addict Biol</addtitle><description>Eating disorders and substance use disorders frequently co‐occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin‐based = 0.23‐0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome‐wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance‐use‐related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism‐based genetic correlations between eating disorder‐ and substance‐use‐related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co‐varying for major depressive disorder loci. The patterns of association between eating disorder‐ and substance‐use‐related phenotypes highlights the potentially complex and substance‐specific relationships among these behaviors.
Eating disorders and substance use disorders frequently co‐occur. Using genome‐wide association studies, we found differential patterns of genetic correlations between specific eating disorder‐ and substance‐use‐ related phenotypes. These patterns of association highlight the potentially complex and substance‐specific associations among eating disorder‐ and substance‐use‐related behaviors.</description><subject>alcohol dependence</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcoholism - genetics</subject><subject>Anorexia</subject><subject>anorexia-nervosa</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biochemistry and Molecular Biology</subject><subject>Biokemi och molekylärbiologi</subject><subject>Bulimia</subject><subject>Bulimia nervosa</subject><subject>Cannabis</subject><subject>Cigarettes</subject><subject>Cognitive science</subject><subject>comorbidity</subject><subject>contributions</subject><subject>Depressive Disorder, Major - genetics</subject><subject>Drug dependence</subject><subject>Drug use</subject><subject>Eating disorders</subject><subject>endocannabinoids</subject><subject>environmental</subject><subject>Feeding and Eating Disorders - genetics</subject><subject>Gene polymorphism</subject><subject>genetic correlation</subject><subject>Genetic diversity</subject><subject>Genetics & genetic processes</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>gwas</subject><subject>Génétique & processus génétiques</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Linkage Disequilibrium</subject><subject>Marijuana</subject><subject>Medicin och hälsovetenskap</subject><subject>Mental disorders</subject><subject>Neuroscience</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psychiatrics and mental health</subject><subject>Risk Factors</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Sciences du vivant</subject><subject>Single-nucleotide polymorphism</subject><subject>Smoking</subject><subject>Substance Abuse</subject><subject>substance use</subject><subject>Substance-Related Disorders - genetics</subject><subject>Tobacco Use Disorder - genetics</subject><subject>twin</subject><subject>Twins</subject><subject>women</subject><issn>1355-6215</issn><issn>1369-1600</issn><issn>1369-1600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9ks1u1DAUhSMEoqWw4AVQJFZIpPVf7JgF0lAKRRqJBbC2HOcm4zYTp3Yyo-5YsuQZeRKcybRQpOJFfHXznXPt5CTJc4yOcVwnuiqPMSkK9CA5xJTLDHOEHk51nmec4PwgeRLCBUKYiJw-Tg4oQZwJhg-TH19W2kOVNtDBYE3qbbhMSxi2AF0KerBdk1Y2OF-B__X9Z6q7Kg1jGQbdGYiNMUxPD60eoku_gs4N1z2EN-nZxlYQobT2bj35u_WEbmM31SE4Y6O769IwjJWF8DR5VOs2wLP9fpR8-3D29fQ8W37--Ol0scwMzxHKdB6vVosaDJK1AcpyrTnjBZVEFrUhHIShVBBCjWSS5choaaTAORelpgLoUZLNvmEL_Viq3tu19tfKaav2rctYgWKCMpxHXt7L995Vf0Q3QswoQkIK-t9Zzdir2GrGSUIkKjiK_NuZj_AaKgPd4HV7d-SdN51dqcZtlGBEEs6jAZ0NWgsNKOdLqzZkJ9zVY9sobVQZJxJeKJLHhJCoej2rVv8MO18sle0C-LVCMV6YYbTBEX-5P6V3VyOEQV240XfxpynCuODx82MZqVczZbwLwUN964yRmlKrYmrVLrWRffH3vW_Jm5hG4GQGtraF6_ud1OL9u9nyN_Kb_hw</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Baker, Jessica H.</creator><creator>Gordon, Scott</creator><creator>Mattheisen, Manuel</creator><creator>Ripke, Stephan</creator><creator>Yao, Shuyang</creator><creator>Adan, Roger A.H.</creator><creator>Boraska Perica, Vesna</creator><creator>Cichon, Sven</creator><creator>Cone, Roger D.</creator><creator>DeSocio, Janiece E.</creator><creator>Docampo, Elisa</creator><creator>Escaramís, Geòrgia</creator><creator>Esko, Tõnu</creator><creator>Favaro, Angela</creator><creator>Fischer, Krista</creator><creator>Föcker, Manuel</creator><creator>Gonidakis, Fragiskos</creator><creator>Guillaume, Sébastien</creator><creator>Guo, Yiran</creator><creator>Hakonarson, Hakon</creator><creator>Hebebrand, Johannes</creator><creator>Helder, Sietske G.</creator><creator>Herms, Stefan</creator><creator>Herzog, Wolfgang</creator><creator>Huckins, Laura M.</creator><creator>Hudson, James I.</creator><creator>Karhunen, Leila</creator><creator>Karwautz, Andreas</creator><creator>Kennedy, James L.</creator><creator>Klump, Kelly L.</creator><creator>Le Hellard, Stephanie</creator><creator>Lin, Bochao Danae</creator><creator>Meulenbelt, Ingrid</creator><creator>Mitchell, Karen</creator><creator>Monteleone, Alessio Maria</creator><creator>Nacmias, Benedetta</creator><creator>Ophoff, Roel A.</creator><creator>Padyukov, Leonid</creator><creator>Palotie, Aarno</creator><creator>Pinto, Dalila</creator><creator>Ricca, Valdo</creator><creator>Ritschel, Franziska</creator><creator>Santonastaso, Paolo</creator><creator>Scherag, André</creator><creator>Seitz, Jochen</creator><creator>Slachtova, Lenka</creator><creator>Slof‐Op't Landt, Margarita C.T.</creator><creator>Slopien, Agnieszka</creator><creator>Szatkiewicz, Jin P.</creator><creator>Wagner, Gudrun</creator><creator>Walton, Esther</creator><creator>Widen, Elisabeth</creator><creator>Crawford, Steven</creator><creator>Johnson, Craig</creator><creator>Mitchell, James</creator><creator>Whiteman, David C.</creator><creator>Birgegård, Andreas</creator><creator>Norring, Claes</creator><creator>Polimanti, Renato</creator><creator>Clarke, Toni‐Kim</creator><creator>Degenhardt, Franziska</creator><creator>Docherty, Anna R.</creator><creator>Foo, Jerome C.</creator><creator>Fox, Louis</creator><creator>Frank, Josef</creator><creator>Hack, Laura M.</creator><creator>Lahti, Jari</creator><creator>Lahti‐Pulkkinen, Marius</creator><creator>Loukola, Anu</creator><creator>Palviainen, Teemu</creator><creator>Saccone, Nancy L.</creator><creator>Salvatore, Jessica E.</creator><creator>Strohmaier, Jana</creator><creator>Wang, Jen‐Chyong</creator><creator>Wills, Amanda G.</creator><creator>Boardman, Jason D.</creator><creator>Choi, Doo‐Sup</creator><creator>Culverhouse, Robert C.</creator><creator>Dahmen, Norbert</creator><creator>Domingue, Benjamin W.</creator><creator>Gäebel, Wolfgang</creator><creator>Ising, Marcus</creator><creator>Keyes, Margaret</creator><creator>Lucae, Susanne</creator><creator>Nurnberger, John I.</creator><creator>Preuss, Ulrich</creator><creator>Bierut, Laura J.</creator><creator>Brown, Sandra A.</creator><creator>Costello, E. 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Jane ; Eriksson, Johan G. ; Foroud, Tatiana M. ; Hesselbrock, Victor ; Johnson, Eric O. ; Stallings, Michael C. ; Vrieze, Scott ; Wade, Tracey D. ; Heath, Andrew C. ; Martin, Nicholas G. ; Breen, Gerome ; Bulik, Cynthia M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6500-a5600f7fec09fce345aa646839298fc26e7c337223c949450ca9c971567ba37e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>alcohol dependence</topic><topic>Alcohol use</topic><topic>Alcoholic beverages</topic><topic>Alcoholism - genetics</topic><topic>Anorexia</topic><topic>anorexia-nervosa</topic><topic>Biochemistry & Molecular Biology</topic><topic>Biochemistry and Molecular Biology</topic><topic>Biokemi och molekylärbiologi</topic><topic>Bulimia</topic><topic>Bulimia nervosa</topic><topic>Cannabis</topic><topic>Cigarettes</topic><topic>Cognitive science</topic><topic>comorbidity</topic><topic>contributions</topic><topic>Depressive Disorder, Major - genetics</topic><topic>Drug dependence</topic><topic>Drug use</topic><topic>Eating disorders</topic><topic>endocannabinoids</topic><topic>environmental</topic><topic>Feeding and Eating Disorders - genetics</topic><topic>Gene polymorphism</topic><topic>genetic correlation</topic><topic>Genetic diversity</topic><topic>Genetics & genetic processes</topic><topic>Genome-wide association studies</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>gwas</topic><topic>Génétique & processus génétiques</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Linkage Disequilibrium</topic><topic>Marijuana</topic><topic>Medicin och hälsovetenskap</topic><topic>Mental disorders</topic><topic>Neuroscience</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Psychiatrics and mental health</topic><topic>Risk Factors</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>Sciences du vivant</topic><topic>Single-nucleotide polymorphism</topic><topic>Smoking</topic><topic>Substance Abuse</topic><topic>substance use</topic><topic>Substance-Related Disorders - genetics</topic><topic>Tobacco Use Disorder - genetics</topic><topic>twin</topic><topic>Twins</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baker, Jessica H.</creatorcontrib><creatorcontrib>Gordon, Scott</creatorcontrib><creatorcontrib>Mattheisen, Manuel</creatorcontrib><creatorcontrib>Ripke, Stephan</creatorcontrib><creatorcontrib>Yao, Shuyang</creatorcontrib><creatorcontrib>Adan, Roger A.H.</creatorcontrib><creatorcontrib>Boraska Perica, Vesna</creatorcontrib><creatorcontrib>Cichon, Sven</creatorcontrib><creatorcontrib>Cone, Roger D.</creatorcontrib><creatorcontrib>DeSocio, Janiece E.</creatorcontrib><creatorcontrib>Docampo, Elisa</creatorcontrib><creatorcontrib>Escaramís, Geòrgia</creatorcontrib><creatorcontrib>Esko, Tõnu</creatorcontrib><creatorcontrib>Favaro, Angela</creatorcontrib><creatorcontrib>Fischer, Krista</creatorcontrib><creatorcontrib>Föcker, Manuel</creatorcontrib><creatorcontrib>Gonidakis, Fragiskos</creatorcontrib><creatorcontrib>Guillaume, Sébastien</creatorcontrib><creatorcontrib>Guo, Yiran</creatorcontrib><creatorcontrib>Hakonarson, Hakon</creatorcontrib><creatorcontrib>Hebebrand, Johannes</creatorcontrib><creatorcontrib>Helder, Sietske G.</creatorcontrib><creatorcontrib>Herms, Stefan</creatorcontrib><creatorcontrib>Herzog, Wolfgang</creatorcontrib><creatorcontrib>Huckins, Laura M.</creatorcontrib><creatorcontrib>Hudson, James I.</creatorcontrib><creatorcontrib>Karhunen, Leila</creatorcontrib><creatorcontrib>Karwautz, Andreas</creatorcontrib><creatorcontrib>Kennedy, James L.</creatorcontrib><creatorcontrib>Klump, Kelly L.</creatorcontrib><creatorcontrib>Le Hellard, Stephanie</creatorcontrib><creatorcontrib>Lin, Bochao Danae</creatorcontrib><creatorcontrib>Meulenbelt, Ingrid</creatorcontrib><creatorcontrib>Mitchell, Karen</creatorcontrib><creatorcontrib>Monteleone, Alessio Maria</creatorcontrib><creatorcontrib>Nacmias, Benedetta</creatorcontrib><creatorcontrib>Ophoff, Roel A.</creatorcontrib><creatorcontrib>Padyukov, Leonid</creatorcontrib><creatorcontrib>Palotie, Aarno</creatorcontrib><creatorcontrib>Pinto, Dalila</creatorcontrib><creatorcontrib>Ricca, Valdo</creatorcontrib><creatorcontrib>Ritschel, Franziska</creatorcontrib><creatorcontrib>Santonastaso, Paolo</creatorcontrib><creatorcontrib>Scherag, André</creatorcontrib><creatorcontrib>Seitz, Jochen</creatorcontrib><creatorcontrib>Slachtova, Lenka</creatorcontrib><creatorcontrib>Slof‐Op't Landt, Margarita C.T.</creatorcontrib><creatorcontrib>Slopien, Agnieszka</creatorcontrib><creatorcontrib>Szatkiewicz, Jin P.</creatorcontrib><creatorcontrib>Wagner, Gudrun</creatorcontrib><creatorcontrib>Walton, Esther</creatorcontrib><creatorcontrib>Widen, Elisabeth</creatorcontrib><creatorcontrib>Crawford, Steven</creatorcontrib><creatorcontrib>Johnson, Craig</creatorcontrib><creatorcontrib>Mitchell, James</creatorcontrib><creatorcontrib>Whiteman, David C.</creatorcontrib><creatorcontrib>Birgegård, Andreas</creatorcontrib><creatorcontrib>Norring, Claes</creatorcontrib><creatorcontrib>Polimanti, Renato</creatorcontrib><creatorcontrib>Clarke, Toni‐Kim</creatorcontrib><creatorcontrib>Degenhardt, Franziska</creatorcontrib><creatorcontrib>Docherty, Anna R.</creatorcontrib><creatorcontrib>Foo, Jerome C.</creatorcontrib><creatorcontrib>Fox, Louis</creatorcontrib><creatorcontrib>Frank, Josef</creatorcontrib><creatorcontrib>Hack, Laura M.</creatorcontrib><creatorcontrib>Lahti, Jari</creatorcontrib><creatorcontrib>Lahti‐Pulkkinen, Marius</creatorcontrib><creatorcontrib>Loukola, Anu</creatorcontrib><creatorcontrib>Palviainen, Teemu</creatorcontrib><creatorcontrib>Saccone, Nancy L.</creatorcontrib><creatorcontrib>Salvatore, Jessica E.</creatorcontrib><creatorcontrib>Strohmaier, Jana</creatorcontrib><creatorcontrib>Wang, Jen‐Chyong</creatorcontrib><creatorcontrib>Wills, Amanda G.</creatorcontrib><creatorcontrib>Boardman, Jason D.</creatorcontrib><creatorcontrib>Choi, Doo‐Sup</creatorcontrib><creatorcontrib>Culverhouse, Robert C.</creatorcontrib><creatorcontrib>Dahmen, Norbert</creatorcontrib><creatorcontrib>Domingue, Benjamin W.</creatorcontrib><creatorcontrib>Gäebel, Wolfgang</creatorcontrib><creatorcontrib>Ising, Marcus</creatorcontrib><creatorcontrib>Keyes, Margaret</creatorcontrib><creatorcontrib>Lucae, Susanne</creatorcontrib><creatorcontrib>Nurnberger, John I.</creatorcontrib><creatorcontrib>Preuss, Ulrich</creatorcontrib><creatorcontrib>Bierut, Laura J.</creatorcontrib><creatorcontrib>Brown, Sandra A.</creatorcontrib><creatorcontrib>Costello, E. Jane</creatorcontrib><creatorcontrib>Eriksson, Johan G.</creatorcontrib><creatorcontrib>Foroud, Tatiana M.</creatorcontrib><creatorcontrib>Hesselbrock, Victor</creatorcontrib><creatorcontrib>Johnson, Eric O.</creatorcontrib><creatorcontrib>Stallings, Michael C.</creatorcontrib><creatorcontrib>Vrieze, Scott</creatorcontrib><creatorcontrib>Wade, Tracey D.</creatorcontrib><creatorcontrib>Heath, Andrew C.</creatorcontrib><creatorcontrib>Martin, Nicholas G.</creatorcontrib><creatorcontrib>Breen, Gerome</creatorcontrib><creatorcontrib>Bulik, Cynthia M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Addiction biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baker, Jessica H.</au><au>Gordon, Scott</au><au>Mattheisen, Manuel</au><au>Ripke, Stephan</au><au>Yao, Shuyang</au><au>Adan, Roger A.H.</au><au>Boraska Perica, Vesna</au><au>Cichon, Sven</au><au>Cone, Roger D.</au><au>DeSocio, Janiece E.</au><au>Docampo, Elisa</au><au>Escaramís, Geòrgia</au><au>Esko, Tõnu</au><au>Favaro, Angela</au><au>Fischer, Krista</au><au>Föcker, Manuel</au><au>Gonidakis, Fragiskos</au><au>Guillaume, Sébastien</au><au>Guo, Yiran</au><au>Hakonarson, Hakon</au><au>Hebebrand, Johannes</au><au>Helder, Sietske G.</au><au>Herms, Stefan</au><au>Herzog, Wolfgang</au><au>Huckins, Laura M.</au><au>Hudson, James I.</au><au>Karhunen, Leila</au><au>Karwautz, Andreas</au><au>Kennedy, James L.</au><au>Klump, Kelly L.</au><au>Le Hellard, Stephanie</au><au>Lin, Bochao Danae</au><au>Meulenbelt, Ingrid</au><au>Mitchell, Karen</au><au>Monteleone, Alessio Maria</au><au>Nacmias, Benedetta</au><au>Ophoff, Roel A.</au><au>Padyukov, Leonid</au><au>Palotie, Aarno</au><au>Pinto, Dalila</au><au>Ricca, Valdo</au><au>Ritschel, Franziska</au><au>Santonastaso, Paolo</au><au>Scherag, André</au><au>Seitz, Jochen</au><au>Slachtova, Lenka</au><au>Slof‐Op't Landt, Margarita C.T.</au><au>Slopien, Agnieszka</au><au>Szatkiewicz, Jin P.</au><au>Wagner, Gudrun</au><au>Walton, Esther</au><au>Widen, Elisabeth</au><au>Crawford, Steven</au><au>Johnson, Craig</au><au>Mitchell, James</au><au>Whiteman, David C.</au><au>Birgegård, Andreas</au><au>Norring, Claes</au><au>Polimanti, Renato</au><au>Clarke, Toni‐Kim</au><au>Degenhardt, Franziska</au><au>Docherty, Anna R.</au><au>Foo, Jerome C.</au><au>Fox, Louis</au><au>Frank, Josef</au><au>Hack, Laura M.</au><au>Lahti, Jari</au><au>Lahti‐Pulkkinen, Marius</au><au>Loukola, Anu</au><au>Palviainen, Teemu</au><au>Saccone, Nancy L.</au><au>Salvatore, Jessica E.</au><au>Strohmaier, Jana</au><au>Wang, Jen‐Chyong</au><au>Wills, Amanda G.</au><au>Boardman, Jason D.</au><au>Choi, Doo‐Sup</au><au>Culverhouse, Robert C.</au><au>Dahmen, Norbert</au><au>Domingue, Benjamin W.</au><au>Gäebel, Wolfgang</au><au>Ising, Marcus</au><au>Keyes, Margaret</au><au>Lucae, Susanne</au><au>Nurnberger, John I.</au><au>Preuss, Ulrich</au><au>Bierut, Laura J.</au><au>Brown, Sandra A.</au><au>Costello, E. Jane</au><au>Eriksson, Johan G.</au><au>Foroud, Tatiana M.</au><au>Hesselbrock, Victor</au><au>Johnson, Eric O.</au><au>Stallings, Michael C.</au><au>Vrieze, Scott</au><au>Wade, Tracey D.</au><au>Heath, Andrew C.</au><au>Martin, Nicholas G.</au><au>Breen, Gerome</au><au>Bulik, Cynthia M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies</atitle><jtitle>Addiction biology</jtitle><addtitle>Addict Biol</addtitle><date>2021-01</date><risdate>2021</risdate><volume>26</volume><issue>1</issue><spage>e12880</spage><epage>n/a</epage><pages>e12880-n/a</pages><issn>1355-6215</issn><issn>1369-1600</issn><eissn>1369-1600</eissn><abstract>Eating disorders and substance use disorders frequently co‐occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin‐based = 0.23‐0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome‐wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance‐use‐related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism‐based genetic correlations between eating disorder‐ and substance‐use‐related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co‐varying for major depressive disorder loci. The patterns of association between eating disorder‐ and substance‐use‐related phenotypes highlights the potentially complex and substance‐specific relationships among these behaviors.
Eating disorders and substance use disorders frequently co‐occur. Using genome‐wide association studies, we found differential patterns of genetic correlations between specific eating disorder‐ and substance‐use‐ related phenotypes. These patterns of association highlight the potentially complex and substance‐specific associations among eating disorder‐ and substance‐use‐related behaviors.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>32064741</pmid><doi>10.1111/adb.12880</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0001-9368-9457</orcidid><orcidid>https://orcid.org/0000-0002-7722-7348</orcidid><orcidid>https://orcid.org/0000-0001-8405-381X</orcidid><orcidid>https://orcid.org/0000-0002-6540-5194</orcidid><orcidid>https://orcid.org/0000-0002-8870-1949</orcidid><orcidid>https://orcid.org/0000-0002-4310-5297</orcidid><orcidid>https://orcid.org/0000-0001-5790-7584</orcidid><orcidid>https://orcid.org/0000-0002-9015-6281</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0002-1724-5405</orcidid><orcidid>https://orcid.org/0000-0002-0719-101X</orcidid><orcidid>https://orcid.org/0000-0002-7315-7899</orcidid><orcidid>https://orcid.org/0000-0002-2786-8200</orcidid><orcidid>https://orcid.org/0000-0002-4496-6451</orcidid><orcidid>https://orcid.org/0000-0003-1080-4339</orcidid><orcidid>https://orcid.org/0000-0002-5236-6149</orcidid><orcidid>https://orcid.org/0000-0002-6621-3493</orcidid><orcidid>https://orcid.org/0000-0003-2814-7461</orcidid><orcidid>https://orcid.org/0000-0002-6619-873X</orcidid><orcidid>https://orcid.org/0000-0002-8070-9938</orcidid><orcidid>https://orcid.org/0000-0003-2053-1792</orcidid><orcidid>https://orcid.org/0000-0003-4867-9465</orcidid><orcidid>https://orcid.org/0000-0002-1876-6368</orcidid><orcidid>https://orcid.org/0000-0002-6769-9982</orcidid><orcidid>https://orcid.org/0000-0003-0871-4596</orcidid><orcidid>https://orcid.org/0000-0002-0576-2472</orcidid><orcidid>https://orcid.org/0000-0002-7798-6221</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6215 |
| ispartof | Addiction biology, 2021-01, Vol.26 (1), p.e12880-n/a |
| issn | 1355-6215 1369-1600 1369-1600 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_473415 |
| source | MEDLINE; SWEPUB Freely available online; Access via Wiley Online Library |
| subjects | alcohol dependence Alcohol use Alcoholic beverages Alcoholism - genetics Anorexia anorexia-nervosa Biochemistry & Molecular Biology Biochemistry and Molecular Biology Biokemi och molekylärbiologi Bulimia Bulimia nervosa Cannabis Cigarettes Cognitive science comorbidity contributions Depressive Disorder, Major - genetics Drug dependence Drug use Eating disorders endocannabinoids environmental Feeding and Eating Disorders - genetics Gene polymorphism genetic correlation Genetic diversity Genetics & genetic processes Genome-wide association studies Genome-Wide Association Study Genomes gwas Génétique & processus génétiques Human health and pathology Humans Life Sciences Linkage Disequilibrium Marijuana Medicin och hälsovetenskap Mental disorders Neuroscience Phenotype Phenotypes Polymorphism, Single Nucleotide Psychiatrics and mental health Risk Factors Schizophrenia Schizophrenia - genetics Sciences du vivant Single-nucleotide polymorphism Smoking Substance Abuse substance use Substance-Related Disorders - genetics Tobacco Use Disorder - genetics twin Twins women |
| title | Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T04%3A12%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Shared%20genetic%20risk%20between%20eating%20disorder%E2%80%90%20and%20substance%E2%80%90use%E2%80%90related%20phenotypes:%20Evidence%20from%20genome%E2%80%90wide%20association%20studies&rft.jtitle=Addiction%20biology&rft.au=Baker,%20Jessica%20H.&rft.date=2021-01&rft.volume=26&rft.issue=1&rft.spage=e12880&rft.epage=n/a&rft.pages=e12880-n/a&rft.issn=1355-6215&rft.eissn=1369-1600&rft_id=info:doi/10.1111/adb.12880&rft_dat=%3Cproquest_swepu%3E2467633719%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2467633719&rft_id=info:pmid/32064741&rfr_iscdi=true |