Profiles of patients on warfarin anticoagulation therapy in a leading tertiary referral hospital in Kenya; findings and implications for Kenya
Background: Patients' profiles affect the outcome with warfarin; however, this data, and its implications, is scarce in resource-poor countries without access to pharmacogenetics or regular INR testing. Objectives: To characterize the profiles of patients on long-term warfarin therapy and subse...
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| Veröffentlicht in: | Expert review of cardiovascular therapy 2020-03, Vol.18 (3), p.165-173 |
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| container_title | Expert review of cardiovascular therapy |
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| creator | Nyamu, David Gitonga Guantai, Anastasia Nkatha Osanjo, George Oyamo Godman, Brian Aklillu, Eleni |
| description | Background: Patients' profiles affect the outcome with warfarin; however, this data, and its implications, is scarce in resource-poor countries without access to pharmacogenetics or regular INR testing.
Objectives: To characterize the profiles of patients on long-term warfarin therapy and subsequently use these to guide future anticoagulation management.
Methods: Cross-sectional study among 180 adult patients receiving warfarin therapy in at a leading referral hospital in Kenya. Sociodemographic characteristics were obtained through face-to-face interviews. Details of warfarin therapy, concomitant medication and comorbidities were retrieved from medical records. Associations between patients' profiles and the clinical indications of anticoagulation were computed at p ≤ 0.05.
Results: Warfarin maintenance dose was 6.17 (±2.75) mg per day. Venous thromboembolism (56.6%) amongst obese patients (p = 0.0019) and cardioembolic events (48.3%) among males (p = 0.0316) aged ≤50 years (p = 0.0436) whose body mass indices were ≤ 25 (p |
| doi_str_mv | 10.1080/14779072.2020.1734452 |
| format | Article |
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Objectives: To characterize the profiles of patients on long-term warfarin therapy and subsequently use these to guide future anticoagulation management.
Methods: Cross-sectional study among 180 adult patients receiving warfarin therapy in at a leading referral hospital in Kenya. Sociodemographic characteristics were obtained through face-to-face interviews. Details of warfarin therapy, concomitant medication and comorbidities were retrieved from medical records. Associations between patients' profiles and the clinical indications of anticoagulation were computed at p ≤ 0.05.
Results: Warfarin maintenance dose was 6.17 (±2.75) mg per day. Venous thromboembolism (56.6%) amongst obese patients (p = 0.0019) and cardioembolic events (48.3%) among males (p = 0.0316) aged ≤50 years (p = 0.0436) whose body mass indices were ≤ 25 (p < 0.0001) were the most common indications. Two-fifths and 45.0% of the patients had at least one other disease and concomitant medications.
Conclusions: Long term warfarin therapy among Kenyans is mainly for overweight or lean middle-aged individuals suffering from venous or cardioembolic diseases. Studies should correlate patients' profiles with warfarin response to guide future management.</description><identifier>ISSN: 1477-9072</identifier><identifier>EISSN: 1744-8344</identifier><identifier>DOI: 10.1080/14779072.2020.1734452</identifier><identifier>PMID: 32090626</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Kenya ; patient Profiles ; Warfarin ; Warfarin Anticoagulation Therapy</subject><ispartof>Expert review of cardiovascular therapy, 2020-03, Vol.18 (3), p.165-173</ispartof><rights>2020 Informa UK Limited, trading as Taylor & Francis Group 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-f30301c01858b1685faab04d0d87b2c16821d6f79b15fa96470dc0faa13f6b453</citedby><cites>FETCH-LOGICAL-c451t-f30301c01858b1685faab04d0d87b2c16821d6f79b15fa96470dc0faa13f6b453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,550,776,881</link.rule.ids><linktorsrc>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:232090626$$EView_record_in_Swedish_Publication_Index_(SWEPUB)$$FView_record_in_$$GSwedish_Publication_Index_(SWEPUB)$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32090626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:232090626$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nyamu, David Gitonga</creatorcontrib><creatorcontrib>Guantai, Anastasia Nkatha</creatorcontrib><creatorcontrib>Osanjo, George Oyamo</creatorcontrib><creatorcontrib>Godman, Brian</creatorcontrib><creatorcontrib>Aklillu, Eleni</creatorcontrib><title>Profiles of patients on warfarin anticoagulation therapy in a leading tertiary referral hospital in Kenya; findings and implications for Kenya</title><title>Expert review of cardiovascular therapy</title><addtitle>Expert Rev Cardiovasc Ther</addtitle><description>Background: Patients' profiles affect the outcome with warfarin; however, this data, and its implications, is scarce in resource-poor countries without access to pharmacogenetics or regular INR testing.
Objectives: To characterize the profiles of patients on long-term warfarin therapy and subsequently use these to guide future anticoagulation management.
Methods: Cross-sectional study among 180 adult patients receiving warfarin therapy in at a leading referral hospital in Kenya. Sociodemographic characteristics were obtained through face-to-face interviews. Details of warfarin therapy, concomitant medication and comorbidities were retrieved from medical records. Associations between patients' profiles and the clinical indications of anticoagulation were computed at p ≤ 0.05.
Results: Warfarin maintenance dose was 6.17 (±2.75) mg per day. Venous thromboembolism (56.6%) amongst obese patients (p = 0.0019) and cardioembolic events (48.3%) among males (p = 0.0316) aged ≤50 years (p = 0.0436) whose body mass indices were ≤ 25 (p < 0.0001) were the most common indications. Two-fifths and 45.0% of the patients had at least one other disease and concomitant medications.
Conclusions: Long term warfarin therapy among Kenyans is mainly for overweight or lean middle-aged individuals suffering from venous or cardioembolic diseases. Studies should correlate patients' profiles with warfarin response to guide future management.</description><subject>Kenya</subject><subject>patient Profiles</subject><subject>Warfarin</subject><subject>Warfarin Anticoagulation Therapy</subject><issn>1477-9072</issn><issn>1744-8344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>D8T</sourceid><recordid>eNp9kc1O3TAQha2KqlDoIxT5BUL9lzgRGxCCtipSWcDamiQ2uOTakW10dV-iz8ykubDsyscz3xn_HEK-cnbGWcu-caV1x7Q4E0xgSUulavGBHHGtVNXi7gA1MtUCHZLPOf9hTKqulp_IoRSsY41ojsjfuxSdn2ym0dEZirehoA50C8lB8oFCKH6I8PgyYRcb5ckmmHd0adHJwujDIy02FQ9pR5N1NiWY6FPMsy8okPtlww7OqfNhgTOOHKnfzJMf_o3M1MW0Qifko4Mp2y_79Zg83FzfX_2obn9__3l1eVsNqualcpJJxgfG27rtedPWDqBnamRjq3sxYEXwsXG66zm2ukZpNg4MIS5d06taHpNqnZu3dn7pzZz8Bq9vInizLz2jskZpKWqBfL3yQ4o54yPfHZyZJQ_zlodZ8jD7PNB3uvpw4saO7663ABC4WAEf8BM2sI1pGk2B3RSTSxAGn438_xmvU3edfg</recordid><startdate>20200303</startdate><enddate>20200303</enddate><creator>Nyamu, David Gitonga</creator><creator>Guantai, Anastasia Nkatha</creator><creator>Osanjo, George Oyamo</creator><creator>Godman, Brian</creator><creator>Aklillu, Eleni</creator><general>Taylor & Francis</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20200303</creationdate><title>Profiles of patients on warfarin anticoagulation therapy in a leading tertiary referral hospital in Kenya; findings and implications for Kenya</title><author>Nyamu, David Gitonga ; Guantai, Anastasia Nkatha ; Osanjo, George Oyamo ; Godman, Brian ; Aklillu, Eleni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-f30301c01858b1685faab04d0d87b2c16821d6f79b15fa96470dc0faa13f6b453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Kenya</topic><topic>patient Profiles</topic><topic>Warfarin</topic><topic>Warfarin Anticoagulation Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nyamu, David Gitonga</creatorcontrib><creatorcontrib>Guantai, Anastasia Nkatha</creatorcontrib><creatorcontrib>Osanjo, George Oyamo</creatorcontrib><creatorcontrib>Godman, Brian</creatorcontrib><creatorcontrib>Aklillu, Eleni</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Expert review of cardiovascular therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Nyamu, David Gitonga</au><au>Guantai, Anastasia Nkatha</au><au>Osanjo, George Oyamo</au><au>Godman, Brian</au><au>Aklillu, Eleni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Profiles of patients on warfarin anticoagulation therapy in a leading tertiary referral hospital in Kenya; findings and implications for Kenya</atitle><jtitle>Expert review of cardiovascular therapy</jtitle><addtitle>Expert Rev Cardiovasc Ther</addtitle><date>2020-03-03</date><risdate>2020</risdate><volume>18</volume><issue>3</issue><spage>165</spage><epage>173</epage><pages>165-173</pages><issn>1477-9072</issn><eissn>1744-8344</eissn><abstract>Background: Patients' profiles affect the outcome with warfarin; however, this data, and its implications, is scarce in resource-poor countries without access to pharmacogenetics or regular INR testing.
Objectives: To characterize the profiles of patients on long-term warfarin therapy and subsequently use these to guide future anticoagulation management.
Methods: Cross-sectional study among 180 adult patients receiving warfarin therapy in at a leading referral hospital in Kenya. Sociodemographic characteristics were obtained through face-to-face interviews. Details of warfarin therapy, concomitant medication and comorbidities were retrieved from medical records. Associations between patients' profiles and the clinical indications of anticoagulation were computed at p ≤ 0.05.
Results: Warfarin maintenance dose was 6.17 (±2.75) mg per day. Venous thromboembolism (56.6%) amongst obese patients (p = 0.0019) and cardioembolic events (48.3%) among males (p = 0.0316) aged ≤50 years (p = 0.0436) whose body mass indices were ≤ 25 (p < 0.0001) were the most common indications. Two-fifths and 45.0% of the patients had at least one other disease and concomitant medications.
Conclusions: Long term warfarin therapy among Kenyans is mainly for overweight or lean middle-aged individuals suffering from venous or cardioembolic diseases. Studies should correlate patients' profiles with warfarin response to guide future management.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>32090626</pmid><doi>10.1080/14779072.2020.1734452</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Kenya patient Profiles Warfarin Warfarin Anticoagulation Therapy |
| title | Profiles of patients on warfarin anticoagulation therapy in a leading tertiary referral hospital in Kenya; findings and implications for Kenya |
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