Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe

This study aims to assess antimicrobial consumption in the pediatric department of a tertiary care public hospital in Zimbabwe. Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as da...

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Veröffentlicht in:Journal of chemotherapy (Florence) 2020-11, Vol.32 (8), p.456-459
Hauptverfasser: Olaru, Ioana D., Meierkord, Anne, Godman, Brian, Ngwenya, Crispen, Fitzgerald, Felicity, Dondo, Vongai, Ferrand, Rashida A., Kranzer, Katharina
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container_end_page 459
container_issue 8
container_start_page 456
container_title Journal of chemotherapy (Florence)
container_volume 32
creator Olaru, Ioana D.
Meierkord, Anne
Godman, Brian
Ngwenya, Crispen
Fitzgerald, Felicity
Dondo, Vongai
Ferrand, Rashida A.
Kranzer, Katharina
description This study aims to assess antimicrobial consumption in the pediatric department of a tertiary care public hospital in Zimbabwe. Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as days of therapy per 100 inpatient days (DOT/100 PD). Adherence of antimicrobial drug prescriptions to the National Guidelines was also evaluated. A total of 121 (93.1%) children were prescribed at least one antimicrobial out of 130 children admitted. The median age was 14 months (IQR: 3 − 48 months). Overall antimicrobial consumption was 155.4 DOT/100 PD (95% CI 146-165.2). The most frequently prescribed antimicrobials were benzylpenicillin, gentamicin and ceftriaxone. Prescriptions were adherent to national guidelines in 57.7% of children. This study shows that there is high antimicrobial drug usage in hospitalized children in Zimbabwe and a considerable proportion of prescriptions are non-adherent with national guidelines.
doi_str_mv 10.1080/1120009X.2020.1734719
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subjects AMR
Anti-Bacterial Agents - administration & dosage
Antibiotic resistance
Antimicrobial consumption
Antimicrobial resistance
Antimicrobial Stewardship
Child
Child, Preschool
Children
Drug Utilization
Female
Guideline Adherence - statistics & numerical data
Humans
Infant
Infant, Newborn
Inpatients - statistics & numerical data
Male
Practice Guidelines as Topic
Practice Patterns, Physicians' - statistics & numerical data
Tertiary Care Centers - standards
Tertiary Care Centers - statistics & numerical data
Zimbabwe
title Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe
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