Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe
This study aims to assess antimicrobial consumption in the pediatric department of a tertiary care public hospital in Zimbabwe. Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as da...
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Veröffentlicht in: | Journal of chemotherapy (Florence) 2020-11, Vol.32 (8), p.456-459 |
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creator | Olaru, Ioana D. Meierkord, Anne Godman, Brian Ngwenya, Crispen Fitzgerald, Felicity Dondo, Vongai Ferrand, Rashida A. Kranzer, Katharina |
description | This study aims to assess antimicrobial consumption in the pediatric department of a tertiary care public hospital in Zimbabwe. Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as days of therapy per 100 inpatient days (DOT/100 PD). Adherence of antimicrobial drug prescriptions to the National Guidelines was also evaluated. A total of 121 (93.1%) children were prescribed at least one antimicrobial out of 130 children admitted. The median age was 14 months (IQR: 3 − 48 months). Overall antimicrobial consumption was 155.4 DOT/100 PD (95% CI 146-165.2). The most frequently prescribed antimicrobials were benzylpenicillin, gentamicin and ceftriaxone. Prescriptions were adherent to national guidelines in 57.7% of children. This study shows that there is high antimicrobial drug usage in hospitalized children in Zimbabwe and a considerable proportion of prescriptions are non-adherent with national guidelines. |
doi_str_mv | 10.1080/1120009X.2020.1734719 |
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Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as days of therapy per 100 inpatient days (DOT/100 PD). Adherence of antimicrobial drug prescriptions to the National Guidelines was also evaluated. A total of 121 (93.1%) children were prescribed at least one antimicrobial out of 130 children admitted. The median age was 14 months (IQR: 3 − 48 months). Overall antimicrobial consumption was 155.4 DOT/100 PD (95% CI 146-165.2). The most frequently prescribed antimicrobials were benzylpenicillin, gentamicin and ceftriaxone. Prescriptions were adherent to national guidelines in 57.7% of children. This study shows that there is high antimicrobial drug usage in hospitalized children in Zimbabwe and a considerable proportion of prescriptions are non-adherent with national guidelines.</description><identifier>ISSN: 1120-009X</identifier><identifier>EISSN: 1973-9478</identifier><identifier>DOI: 10.1080/1120009X.2020.1734719</identifier><identifier>PMID: 32114964</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>AMR ; Anti-Bacterial Agents - administration & dosage ; Antibiotic resistance ; Antimicrobial consumption ; Antimicrobial resistance ; Antimicrobial Stewardship ; Child ; Child, Preschool ; Children ; Drug Utilization ; Female ; Guideline Adherence - statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Inpatients - statistics & numerical data ; Male ; Practice Guidelines as Topic ; Practice Patterns, Physicians' - statistics & numerical data ; Tertiary Care Centers - standards ; Tertiary Care Centers - statistics & numerical data ; Zimbabwe</subject><ispartof>Journal of chemotherapy (Florence), 2020-11, Vol.32 (8), p.456-459</ispartof><rights>2020 Edizioni Scientifi che per l'Informazione su Farmaci e Terapia 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-67235e8ac5aac18b73158cbfe52f8f9687a1cb56ffe0f423eef8320828ab3dc53</citedby><cites>FETCH-LOGICAL-c506t-67235e8ac5aac18b73158cbfe52f8f9687a1cb56ffe0f423eef8320828ab3dc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,550,776,881</link.rule.ids><linktorsrc>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:143158879$$EView_record_in_Swedish_Publication_Index_(SWEPUB)$$FView_record_in_$$GSwedish_Publication_Index_(SWEPUB)$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32114964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:143158879$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Olaru, Ioana D.</creatorcontrib><creatorcontrib>Meierkord, Anne</creatorcontrib><creatorcontrib>Godman, Brian</creatorcontrib><creatorcontrib>Ngwenya, Crispen</creatorcontrib><creatorcontrib>Fitzgerald, Felicity</creatorcontrib><creatorcontrib>Dondo, Vongai</creatorcontrib><creatorcontrib>Ferrand, Rashida A.</creatorcontrib><creatorcontrib>Kranzer, Katharina</creatorcontrib><title>Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe</title><title>Journal of chemotherapy (Florence)</title><addtitle>J Chemother</addtitle><description>This study aims to assess antimicrobial consumption in the pediatric department of a tertiary care public hospital in Zimbabwe. Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as days of therapy per 100 inpatient days (DOT/100 PD). Adherence of antimicrobial drug prescriptions to the National Guidelines was also evaluated. A total of 121 (93.1%) children were prescribed at least one antimicrobial out of 130 children admitted. The median age was 14 months (IQR: 3 − 48 months). Overall antimicrobial consumption was 155.4 DOT/100 PD (95% CI 146-165.2). The most frequently prescribed antimicrobials were benzylpenicillin, gentamicin and ceftriaxone. Prescriptions were adherent to national guidelines in 57.7% of children. This study shows that there is high antimicrobial drug usage in hospitalized children in Zimbabwe and a considerable proportion of prescriptions are non-adherent with national guidelines.</description><subject>AMR</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Antibiotic resistance</subject><subject>Antimicrobial consumption</subject><subject>Antimicrobial resistance</subject><subject>Antimicrobial Stewardship</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Drug Utilization</subject><subject>Female</subject><subject>Guideline Adherence - statistics & numerical data</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inpatients - statistics & numerical data</subject><subject>Male</subject><subject>Practice Guidelines as Topic</subject><subject>Practice Patterns, Physicians' - statistics & numerical data</subject><subject>Tertiary Care Centers - standards</subject><subject>Tertiary Care Centers - statistics & numerical data</subject><subject>Zimbabwe</subject><issn>1120-009X</issn><issn>1973-9478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kU1vFDEMhiMEolXpTwDNkcuUfMzk44KoKr6kSlxAQlyCJ-OUwMxkSWZZ9d_j1W4reuEUx3782vLL2HPBLwS3_JUQknPuvl5ILillVGeEe8ROhTOqdZ2xjykmpt1DJ-y81p_Ecy2NcvopO1FSiM7p7pR9v6wVa51xWZscG1jWNKdQ8pBgarYVKTM2m4I1lDSk5YZiCGsKWBuY8_6PY4K1pNCkZQNrIqFKYfMtzQMMO3zGnkSYKp4f3zP25d3bz1cf2utP7z9eXV63oed6bbWRqkcLoQcIwg5Gid6GIWIvo41OWwMiDL2OEXnspEKMVklupYVBjaFXZ6w96NYdbraD35Q0Q7n1GZI_pn5RhL4jaa6If33gqTLjGGjvAtODtoeVJf3wN_mPN5pOpzoSeHkUKPn3Fuvq51QDThMsmLfVS6WdNb1zmtD-gNJhay0Y78cI7veG-jtD_d5QfzSU-l78u-N91519BLw5AGmJucywy2Ua_Qq3Uy6xwBJS9er_M_4CGS-ziQ</recordid><startdate>20201116</startdate><enddate>20201116</enddate><creator>Olaru, Ioana D.</creator><creator>Meierkord, Anne</creator><creator>Godman, Brian</creator><creator>Ngwenya, Crispen</creator><creator>Fitzgerald, Felicity</creator><creator>Dondo, Vongai</creator><creator>Ferrand, Rashida A.</creator><creator>Kranzer, Katharina</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20201116</creationdate><title>Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe</title><author>Olaru, Ioana D. ; Meierkord, Anne ; Godman, Brian ; Ngwenya, Crispen ; Fitzgerald, Felicity ; Dondo, Vongai ; Ferrand, Rashida A. ; Kranzer, Katharina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-67235e8ac5aac18b73158cbfe52f8f9687a1cb56ffe0f423eef8320828ab3dc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>AMR</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Antibiotic resistance</topic><topic>Antimicrobial consumption</topic><topic>Antimicrobial resistance</topic><topic>Antimicrobial Stewardship</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Drug Utilization</topic><topic>Female</topic><topic>Guideline Adherence - statistics & numerical data</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Inpatients - statistics & numerical data</topic><topic>Male</topic><topic>Practice Guidelines as Topic</topic><topic>Practice Patterns, Physicians' - statistics & numerical data</topic><topic>Tertiary Care Centers - standards</topic><topic>Tertiary Care Centers - statistics & numerical data</topic><topic>Zimbabwe</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olaru, Ioana D.</creatorcontrib><creatorcontrib>Meierkord, Anne</creatorcontrib><creatorcontrib>Godman, Brian</creatorcontrib><creatorcontrib>Ngwenya, Crispen</creatorcontrib><creatorcontrib>Fitzgerald, Felicity</creatorcontrib><creatorcontrib>Dondo, Vongai</creatorcontrib><creatorcontrib>Ferrand, Rashida A.</creatorcontrib><creatorcontrib>Kranzer, Katharina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of chemotherapy (Florence)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Olaru, Ioana D.</au><au>Meierkord, Anne</au><au>Godman, Brian</au><au>Ngwenya, Crispen</au><au>Fitzgerald, Felicity</au><au>Dondo, Vongai</au><au>Ferrand, Rashida A.</au><au>Kranzer, Katharina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe</atitle><jtitle>Journal of chemotherapy (Florence)</jtitle><addtitle>J Chemother</addtitle><date>2020-11-16</date><risdate>2020</risdate><volume>32</volume><issue>8</issue><spage>456</spage><epage>459</epage><pages>456-459</pages><issn>1120-009X</issn><eissn>1973-9478</eissn><abstract>This study aims to assess antimicrobial consumption in the pediatric department of a tertiary care public hospital in Zimbabwe. Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as days of therapy per 100 inpatient days (DOT/100 PD). Adherence of antimicrobial drug prescriptions to the National Guidelines was also evaluated. A total of 121 (93.1%) children were prescribed at least one antimicrobial out of 130 children admitted. The median age was 14 months (IQR: 3 − 48 months). Overall antimicrobial consumption was 155.4 DOT/100 PD (95% CI 146-165.2). The most frequently prescribed antimicrobials were benzylpenicillin, gentamicin and ceftriaxone. Prescriptions were adherent to national guidelines in 57.7% of children. 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subjects | AMR Anti-Bacterial Agents - administration & dosage Antibiotic resistance Antimicrobial consumption Antimicrobial resistance Antimicrobial Stewardship Child Child, Preschool Children Drug Utilization Female Guideline Adherence - statistics & numerical data Humans Infant Infant, Newborn Inpatients - statistics & numerical data Male Practice Guidelines as Topic Practice Patterns, Physicians' - statistics & numerical data Tertiary Care Centers - standards Tertiary Care Centers - statistics & numerical data Zimbabwe |
title | Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe |
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