Preoperative antibiotic prophylaxis regimen in brain tumour surgery in Sweden: a quasi-experimental study
Background There has been varied clinical practice concerning antibiotic prophylaxis in patients undergoing craniotomy. In Sweden, both Cloxacillin and Cefuroxime have frequently been used. We aimed to study the clinical effectiveness of these two regimens. Methods A quasi-experimental design was us...
Gespeichert in:
| Veröffentlicht in: | Acta neurochirurgica 2020-11, Vol.162 (11), p.2849-2856 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2856 |
|---|---|
| container_issue | 11 |
| container_start_page | 2849 |
| container_title | Acta neurochirurgica |
| container_volume | 162 |
| creator | Skyrman, Simon Bartek, Jiri Haghighi, Maryam Fornebo, Ida Skoglund, Tomas Jakola, Asgeir Store von Vogelsang, Ann-Christin Förander, Petter |
| description | Background
There has been varied clinical practice concerning antibiotic prophylaxis in patients undergoing craniotomy. In Sweden, both Cloxacillin and Cefuroxime have frequently been used. We aimed to study the clinical effectiveness of these two regimens.
Methods
A quasi-experimental design was used. The sample consisted of 580 adult (> 18 years) patients operated 2012–2015, of which 375 received Cloxacillin (pre-intervention group) and 205 received Cefuroxime (intervention group). Primary endpoint was the incidence of surgical site infection (SSI) 12 months after surgery, while secondary endpoints were the need for reoperation due to SSI, the amount antibiotics used and the number of visits in the outpatient clinic related to SSI. A control group from another institution was reviewed to rule out clinical trial effects.
Results
When analysed by intention to treat, the pre-intervention group had a significant higher incidence of SSI, 13.3% (50/375) vs 5.4% (11/205) in the intervention group (
p
|
| doi_str_mv | 10.1007/s00701-020-04309-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_471455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2522964486</sourcerecordid><originalsourceid>FETCH-LOGICAL-c550t-3479405ed8bb554e145f53d3323a9f827ad16f5c83da7aad24a552c3f8d14f023</originalsourceid><addsrcrecordid>eNp9kstu1TAQhi0Eohd4ARYoEhs2Bl9zYYFUVVCQKrUSsLacZJK65MSpHbc9b8-kORTaRTcTe-ab8czkJ-QNZx84Y8XHiIZxygSjTElW0fwZ2WeVEhQNe45nhuFc5OUeOYjxEm-iUPIl2ZNClpJxuU_ceQA_QbCzu4bMjrOrnZ9dk03BTxfbwd66mAXo3QbGzI1ZHSzaOW18CllMoYewXfw_bqCF8VNms6tko6Nwi0WXpNkOWZxTu31FXnR2iPB69z0kv75--Xn8jZ6enXw_PjqljdZsplIV2LyGtqxrrRVwpTstW4kt26orRWFbnne6KWVrC2tboazWopFd2XLVMSEPCV3rxhuYUm0mbMOGrfHWmZ3rN57AqAJr6yf5Pk0GXX1aeFFJWXDkP688whtoGxwx2OFB2sPI6C5M769NgfNJvjz4flcg-KsEcTYbFxsYBjuCT9EIxZhW-Yq-e4Re4t5HXJ8RWogqV6rMkRIr1QQfY4DuvhnOzKIUsyrFoFLMnVLMkvT2_zHuU_5KAwG52wuGRvzP_95-ouwfXJvMaA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2522964486</pqid></control><display><type>article</type><title>Preoperative antibiotic prophylaxis regimen in brain tumour surgery in Sweden: a quasi-experimental study</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>SWEPUB Freely available online</source><creator>Skyrman, Simon ; Bartek, Jiri ; Haghighi, Maryam ; Fornebo, Ida ; Skoglund, Tomas ; Jakola, Asgeir Store ; von Vogelsang, Ann-Christin ; Förander, Petter</creator><creatorcontrib>Skyrman, Simon ; Bartek, Jiri ; Haghighi, Maryam ; Fornebo, Ida ; Skoglund, Tomas ; Jakola, Asgeir Store ; von Vogelsang, Ann-Christin ; Förander, Petter</creatorcontrib><description>Background
There has been varied clinical practice concerning antibiotic prophylaxis in patients undergoing craniotomy. In Sweden, both Cloxacillin and Cefuroxime have frequently been used. We aimed to study the clinical effectiveness of these two regimens.
Methods
A quasi-experimental design was used. The sample consisted of 580 adult (> 18 years) patients operated 2012–2015, of which 375 received Cloxacillin (pre-intervention group) and 205 received Cefuroxime (intervention group). Primary endpoint was the incidence of surgical site infection (SSI) 12 months after surgery, while secondary endpoints were the need for reoperation due to SSI, the amount antibiotics used and the number of visits in the outpatient clinic related to SSI. A control group from another institution was reviewed to rule out clinical trial effects.
Results
When analysed by intention to treat, the pre-intervention group had a significant higher incidence of SSI, 13.3% (50/375) vs 5.4% (11/205) in the intervention group (
p
< 0.01). A treatment per protocol analysis confirmed the result. The number of reoperations due to SSI were significantly reduced in the intervention group, 3.4% (7/205) vs 8.3% (31/375) (
p
= 0.02), as was the total antibiotic use (
p
= 0.03) and the number of visits in the outpatient clinic (
p
< 0.01). In the control group, the reoperation rate as result of SSI was lower (
p
= 0.02) prior to the opposite change from Cefuroxime to Cloxacillin, 1.8% (27/1529) vs 3.1% (43/1378).
Conclusion
In Sweden, Cefuroxime as prophylaxis in brain tumour surgery by craniotomy seems to be superior to Cloxacillin.</description><identifier>ISSN: 0001-6268</identifier><identifier>ISSN: 0942-0940</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/s00701-020-04309-6</identifier><identifier>PMID: 32383013</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adult ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Antibiotic Prophylaxis - methods ; Antibiotics ; Brain cancer ; Brain Neoplasms - surgery ; Brain tumors ; Cefuroxime ; Cefuroxime - administration & dosage ; Cefuroxime - therapeutic use ; Cloxacillin ; Disease prevention ; Female ; Humans ; Incidence ; Infection ; Infectious Medicine ; Infektionsmedicin ; Interventional Radiology ; Kirurgi ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Minimally Invasive Surgery ; Neurologi ; Neurology ; Neuroradiology ; Neurosurgery ; Neurosurgical Procedures - adverse effects ; Neurosurgical Procedures - methods ; Original - Infection ; Original Article - Infection ; Outpatient care facilities ; Patients ; Prophylaxis ; Quasi-experimental methods ; Surgery ; Surgical Orthopedics ; Surgical site infections ; Surgical Wound Infection - drug therapy ; Surgical Wound Infection - epidemiology ; Surgical Wound Infection - prevention & control ; Sweden ; Treatment Outcome</subject><ispartof>Acta neurochirurgica, 2020-11, Vol.162 (11), p.2849-2856</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-3479405ed8bb554e145f53d3323a9f827ad16f5c83da7aad24a552c3f8d14f023</citedby><cites>FETCH-LOGICAL-c550t-3479405ed8bb554e145f53d3323a9f827ad16f5c83da7aad24a552c3f8d14f023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00701-020-04309-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00701-020-04309-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32383013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/293371$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:143614919$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Skyrman, Simon</creatorcontrib><creatorcontrib>Bartek, Jiri</creatorcontrib><creatorcontrib>Haghighi, Maryam</creatorcontrib><creatorcontrib>Fornebo, Ida</creatorcontrib><creatorcontrib>Skoglund, Tomas</creatorcontrib><creatorcontrib>Jakola, Asgeir Store</creatorcontrib><creatorcontrib>von Vogelsang, Ann-Christin</creatorcontrib><creatorcontrib>Förander, Petter</creatorcontrib><title>Preoperative antibiotic prophylaxis regimen in brain tumour surgery in Sweden: a quasi-experimental study</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir</addtitle><addtitle>Acta Neurochir (Wien)</addtitle><description>Background
There has been varied clinical practice concerning antibiotic prophylaxis in patients undergoing craniotomy. In Sweden, both Cloxacillin and Cefuroxime have frequently been used. We aimed to study the clinical effectiveness of these two regimens.
Methods
A quasi-experimental design was used. The sample consisted of 580 adult (> 18 years) patients operated 2012–2015, of which 375 received Cloxacillin (pre-intervention group) and 205 received Cefuroxime (intervention group). Primary endpoint was the incidence of surgical site infection (SSI) 12 months after surgery, while secondary endpoints were the need for reoperation due to SSI, the amount antibiotics used and the number of visits in the outpatient clinic related to SSI. A control group from another institution was reviewed to rule out clinical trial effects.
Results
When analysed by intention to treat, the pre-intervention group had a significant higher incidence of SSI, 13.3% (50/375) vs 5.4% (11/205) in the intervention group (
p
< 0.01). A treatment per protocol analysis confirmed the result. The number of reoperations due to SSI were significantly reduced in the intervention group, 3.4% (7/205) vs 8.3% (31/375) (
p
= 0.02), as was the total antibiotic use (
p
= 0.03) and the number of visits in the outpatient clinic (
p
< 0.01). In the control group, the reoperation rate as result of SSI was lower (
p
= 0.02) prior to the opposite change from Cefuroxime to Cloxacillin, 1.8% (27/1529) vs 3.1% (43/1378).
Conclusion
In Sweden, Cefuroxime as prophylaxis in brain tumour surgery by craniotomy seems to be superior to Cloxacillin.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotic Prophylaxis - methods</subject><subject>Antibiotics</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - surgery</subject><subject>Brain tumors</subject><subject>Cefuroxime</subject><subject>Cefuroxime - administration & dosage</subject><subject>Cefuroxime - therapeutic use</subject><subject>Cloxacillin</subject><subject>Disease prevention</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infection</subject><subject>Infectious Medicine</subject><subject>Infektionsmedicin</subject><subject>Interventional Radiology</subject><subject>Kirurgi</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Minimally Invasive Surgery</subject><subject>Neurologi</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Neurosurgical Procedures - adverse effects</subject><subject>Neurosurgical Procedures - methods</subject><subject>Original - Infection</subject><subject>Original Article - Infection</subject><subject>Outpatient care facilities</subject><subject>Patients</subject><subject>Prophylaxis</subject><subject>Quasi-experimental methods</subject><subject>Surgery</subject><subject>Surgical Orthopedics</subject><subject>Surgical site infections</subject><subject>Surgical Wound Infection - drug therapy</subject><subject>Surgical Wound Infection - epidemiology</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Sweden</subject><subject>Treatment Outcome</subject><issn>0001-6268</issn><issn>0942-0940</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>D8T</sourceid><recordid>eNp9kstu1TAQhi0Eohd4ARYoEhs2Bl9zYYFUVVCQKrUSsLacZJK65MSpHbc9b8-kORTaRTcTe-ab8czkJ-QNZx84Y8XHiIZxygSjTElW0fwZ2WeVEhQNe45nhuFc5OUeOYjxEm-iUPIl2ZNClpJxuU_ceQA_QbCzu4bMjrOrnZ9dk03BTxfbwd66mAXo3QbGzI1ZHSzaOW18CllMoYewXfw_bqCF8VNms6tko6Nwi0WXpNkOWZxTu31FXnR2iPB69z0kv75--Xn8jZ6enXw_PjqljdZsplIV2LyGtqxrrRVwpTstW4kt26orRWFbnne6KWVrC2tboazWopFd2XLVMSEPCV3rxhuYUm0mbMOGrfHWmZ3rN57AqAJr6yf5Pk0GXX1aeFFJWXDkP688whtoGxwx2OFB2sPI6C5M769NgfNJvjz4flcg-KsEcTYbFxsYBjuCT9EIxZhW-Yq-e4Re4t5HXJ8RWogqV6rMkRIr1QQfY4DuvhnOzKIUsyrFoFLMnVLMkvT2_zHuU_5KAwG52wuGRvzP_95-ouwfXJvMaA</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Skyrman, Simon</creator><creator>Bartek, Jiri</creator><creator>Haghighi, Maryam</creator><creator>Fornebo, Ida</creator><creator>Skoglund, Tomas</creator><creator>Jakola, Asgeir Store</creator><creator>von Vogelsang, Ann-Christin</creator><creator>Förander, Petter</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20201101</creationdate><title>Preoperative antibiotic prophylaxis regimen in brain tumour surgery in Sweden: a quasi-experimental study</title><author>Skyrman, Simon ; Bartek, Jiri ; Haghighi, Maryam ; Fornebo, Ida ; Skoglund, Tomas ; Jakola, Asgeir Store ; von Vogelsang, Ann-Christin ; Förander, Petter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-3479405ed8bb554e145f53d3323a9f827ad16f5c83da7aad24a552c3f8d14f023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotic Prophylaxis - methods</topic><topic>Antibiotics</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - surgery</topic><topic>Brain tumors</topic><topic>Cefuroxime</topic><topic>Cefuroxime - administration & dosage</topic><topic>Cefuroxime - therapeutic use</topic><topic>Cloxacillin</topic><topic>Disease prevention</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infection</topic><topic>Infectious Medicine</topic><topic>Infektionsmedicin</topic><topic>Interventional Radiology</topic><topic>Kirurgi</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Minimally Invasive Surgery</topic><topic>Neurologi</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Neurosurgical Procedures - adverse effects</topic><topic>Neurosurgical Procedures - methods</topic><topic>Original - Infection</topic><topic>Original Article - Infection</topic><topic>Outpatient care facilities</topic><topic>Patients</topic><topic>Prophylaxis</topic><topic>Quasi-experimental methods</topic><topic>Surgery</topic><topic>Surgical Orthopedics</topic><topic>Surgical site infections</topic><topic>Surgical Wound Infection - drug therapy</topic><topic>Surgical Wound Infection - epidemiology</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Sweden</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skyrman, Simon</creatorcontrib><creatorcontrib>Bartek, Jiri</creatorcontrib><creatorcontrib>Haghighi, Maryam</creatorcontrib><creatorcontrib>Fornebo, Ida</creatorcontrib><creatorcontrib>Skoglund, Tomas</creatorcontrib><creatorcontrib>Jakola, Asgeir Store</creatorcontrib><creatorcontrib>von Vogelsang, Ann-Christin</creatorcontrib><creatorcontrib>Förander, Petter</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skyrman, Simon</au><au>Bartek, Jiri</au><au>Haghighi, Maryam</au><au>Fornebo, Ida</au><au>Skoglund, Tomas</au><au>Jakola, Asgeir Store</au><au>von Vogelsang, Ann-Christin</au><au>Förander, Petter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative antibiotic prophylaxis regimen in brain tumour surgery in Sweden: a quasi-experimental study</atitle><jtitle>Acta neurochirurgica</jtitle><stitle>Acta Neurochir</stitle><addtitle>Acta Neurochir (Wien)</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>162</volume><issue>11</issue><spage>2849</spage><epage>2856</epage><pages>2849-2856</pages><issn>0001-6268</issn><issn>0942-0940</issn><eissn>0942-0940</eissn><abstract>Background
There has been varied clinical practice concerning antibiotic prophylaxis in patients undergoing craniotomy. In Sweden, both Cloxacillin and Cefuroxime have frequently been used. We aimed to study the clinical effectiveness of these two regimens.
Methods
A quasi-experimental design was used. The sample consisted of 580 adult (> 18 years) patients operated 2012–2015, of which 375 received Cloxacillin (pre-intervention group) and 205 received Cefuroxime (intervention group). Primary endpoint was the incidence of surgical site infection (SSI) 12 months after surgery, while secondary endpoints were the need for reoperation due to SSI, the amount antibiotics used and the number of visits in the outpatient clinic related to SSI. A control group from another institution was reviewed to rule out clinical trial effects.
Results
When analysed by intention to treat, the pre-intervention group had a significant higher incidence of SSI, 13.3% (50/375) vs 5.4% (11/205) in the intervention group (
p
< 0.01). A treatment per protocol analysis confirmed the result. The number of reoperations due to SSI were significantly reduced in the intervention group, 3.4% (7/205) vs 8.3% (31/375) (
p
= 0.02), as was the total antibiotic use (
p
= 0.03) and the number of visits in the outpatient clinic (
p
< 0.01). In the control group, the reoperation rate as result of SSI was lower (
p
= 0.02) prior to the opposite change from Cefuroxime to Cloxacillin, 1.8% (27/1529) vs 3.1% (43/1378).
Conclusion
In Sweden, Cefuroxime as prophylaxis in brain tumour surgery by craniotomy seems to be superior to Cloxacillin.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>32383013</pmid><doi>10.1007/s00701-020-04309-6</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6268 |
| ispartof | Acta neurochirurgica, 2020-11, Vol.162 (11), p.2849-2856 |
| issn | 0001-6268 0942-0940 0942-0940 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_471455 |
| source | MEDLINE; SpringerLink Journals; SWEPUB Freely available online |
| subjects | Adult Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibiotic Prophylaxis - methods Antibiotics Brain cancer Brain Neoplasms - surgery Brain tumors Cefuroxime Cefuroxime - administration & dosage Cefuroxime - therapeutic use Cloxacillin Disease prevention Female Humans Incidence Infection Infectious Medicine Infektionsmedicin Interventional Radiology Kirurgi Male Medicine Medicine & Public Health Middle Aged Minimally Invasive Surgery Neurologi Neurology Neuroradiology Neurosurgery Neurosurgical Procedures - adverse effects Neurosurgical Procedures - methods Original - Infection Original Article - Infection Outpatient care facilities Patients Prophylaxis Quasi-experimental methods Surgery Surgical Orthopedics Surgical site infections Surgical Wound Infection - drug therapy Surgical Wound Infection - epidemiology Surgical Wound Infection - prevention & control Sweden Treatment Outcome |
| title | Preoperative antibiotic prophylaxis regimen in brain tumour surgery in Sweden: a quasi-experimental study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T02%3A05%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preoperative%20antibiotic%20prophylaxis%20regimen%20in%20brain%20tumour%20surgery%20in%20Sweden:%20a%20quasi-experimental%20study&rft.jtitle=Acta%20neurochirurgica&rft.au=Skyrman,%20Simon&rft.date=2020-11-01&rft.volume=162&rft.issue=11&rft.spage=2849&rft.epage=2856&rft.pages=2849-2856&rft.issn=0001-6268&rft.eissn=0942-0940&rft_id=info:doi/10.1007/s00701-020-04309-6&rft_dat=%3Cproquest_swepu%3E2522964486%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2522964486&rft_id=info:pmid/32383013&rfr_iscdi=true |