Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease
Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer’s disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connec...
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| Veröffentlicht in: | Trends in molecular medicine 2020-09, Vol.26 (9), p.803-818 |
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| creator | Berger, Thomas Lee, Hyunah Young, Allan H. Aarsland, Dag Thuret, Sandrine |
| description | Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer’s disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.
Human AHN is severely depleted in both MDD and AD indicated by reduction of distinct neurogenic markers and hippocampal volume.Human AHN might be a converging mechanism for MDD and AD, indicating clinical as well as genetic links.Human AHN might display an interesting therapeutic target to potentially develop novel treatment strategies for MDD and AD. |
| doi_str_mv | 10.1016/j.molmed.2020.03.010 |
| format | Article |
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Human AHN is severely depleted in both MDD and AD indicated by reduction of distinct neurogenic markers and hippocampal volume.Human AHN might be a converging mechanism for MDD and AD, indicating clinical as well as genetic links.Human AHN might display an interesting therapeutic target to potentially develop novel treatment strategies for MDD and AD.</description><identifier>ISSN: 1471-4914</identifier><identifier>ISSN: 1471-499X</identifier><identifier>EISSN: 1471-499X</identifier><identifier>DOI: 10.1016/j.molmed.2020.03.010</identifier><identifier>PMID: 32418723</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>adult hippocampal neurogenesis ; Alzheimer Disease - physiopathology ; Alzheimer’s disease ; Animals ; Depressive Disorder, Major - physiopathology ; Hippocampus - physiopathology ; Humans ; major depressive disorder ; Medicin och hälsovetenskap ; Neurogenesis - physiology</subject><ispartof>Trends in molecular medicine, 2020-09, Vol.26 (9), p.803-818</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-7bc721c64d811ce6bde9156ad8fb801fdb384df84933d0a8e26dc0d1d57251ac3</citedby><cites>FETCH-LOGICAL-c450t-7bc721c64d811ce6bde9156ad8fb801fdb384df84933d0a8e26dc0d1d57251ac3</cites><orcidid>0000-0003-1260-8083</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.molmed.2020.03.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32418723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:144610480$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Berger, Thomas</creatorcontrib><creatorcontrib>Lee, Hyunah</creatorcontrib><creatorcontrib>Young, Allan H.</creatorcontrib><creatorcontrib>Aarsland, Dag</creatorcontrib><creatorcontrib>Thuret, Sandrine</creatorcontrib><title>Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease</title><title>Trends in molecular medicine</title><addtitle>Trends Mol Med</addtitle><description>Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer’s disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.
Human AHN is severely depleted in both MDD and AD indicated by reduction of distinct neurogenic markers and hippocampal volume.Human AHN might be a converging mechanism for MDD and AD, indicating clinical as well as genetic links.Human AHN might display an interesting therapeutic target to potentially develop novel treatment strategies for MDD and AD.</description><subject>adult hippocampal neurogenesis</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer’s disease</subject><subject>Animals</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>major depressive disorder</subject><subject>Medicin och hälsovetenskap</subject><subject>Neurogenesis - physiology</subject><issn>1471-4914</issn><issn>1471-499X</issn><issn>1471-499X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhiMEoqXwBgjlyCVhxnYS54K0agtFKnChEjfLsSfgJYmDvSmCE6_B6_EkeJXdcoKTR57vm5Hmz7KnCCUC1i-25eiHkWzJgEEJvASEe9kpigYL0bYf79_VKE6yRzFuAbBqGvkwO-FMoGwYP81uNnYZdvmVm2dv9DjrIX9HS_CfaKLoYu6m_K3e-pBf0BwoRndL-YWLPlgKuZ5svhl-fCY3Uvj981fct0hHepw96PUQ6cnhPctuXl1-OL8qrt-_fnO-uS6MqGBXNJ1pGJpaWIloqO4stVjV2sq-k4C97bgUtpei5dyClsRqa8CirRpWoTb8LCvWufEbzUun5uBGHb4rr506fH1JFal0CMZE4tt_8nPw9q90FFGIGkFISO7z1U3g14XiTo0uGhoGPZFfomICBG-4qHhCxYqa4GMM1N8tQlD78NRWreGpfXgKuErhJe3ZYcPS7XtH6ZhWAl6uAKWb3joKKhpHkyHrApmdst79f8Mf1Q-vwA</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Berger, Thomas</creator><creator>Lee, Hyunah</creator><creator>Young, Allan H.</creator><creator>Aarsland, Dag</creator><creator>Thuret, Sandrine</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0003-1260-8083</orcidid></search><sort><creationdate>20200901</creationdate><title>Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease</title><author>Berger, Thomas ; Lee, Hyunah ; Young, Allan H. ; Aarsland, Dag ; Thuret, Sandrine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-7bc721c64d811ce6bde9156ad8fb801fdb384df84933d0a8e26dc0d1d57251ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>adult hippocampal neurogenesis</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer’s disease</topic><topic>Animals</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>major depressive disorder</topic><topic>Medicin och hälsovetenskap</topic><topic>Neurogenesis - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berger, Thomas</creatorcontrib><creatorcontrib>Lee, Hyunah</creatorcontrib><creatorcontrib>Young, Allan H.</creatorcontrib><creatorcontrib>Aarsland, Dag</creatorcontrib><creatorcontrib>Thuret, Sandrine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Trends in molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berger, Thomas</au><au>Lee, Hyunah</au><au>Young, Allan H.</au><au>Aarsland, Dag</au><au>Thuret, Sandrine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease</atitle><jtitle>Trends in molecular medicine</jtitle><addtitle>Trends Mol Med</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>26</volume><issue>9</issue><spage>803</spage><epage>818</epage><pages>803-818</pages><issn>1471-4914</issn><issn>1471-499X</issn><eissn>1471-499X</eissn><abstract>Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer’s disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.
Human AHN is severely depleted in both MDD and AD indicated by reduction of distinct neurogenic markers and hippocampal volume.Human AHN might be a converging mechanism for MDD and AD, indicating clinical as well as genetic links.Human AHN might display an interesting therapeutic target to potentially develop novel treatment strategies for MDD and AD.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32418723</pmid><doi>10.1016/j.molmed.2020.03.010</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-1260-8083</orcidid></addata></record> |
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| subjects | adult hippocampal neurogenesis Alzheimer Disease - physiopathology Alzheimer’s disease Animals Depressive Disorder, Major - physiopathology Hippocampus - physiopathology Humans major depressive disorder Medicin och hälsovetenskap Neurogenesis - physiology |
| title | Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease |
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