The cellular basis of increased PET hypoxia tracer uptake in focal cerebral ischemia with comparison between [18F]FMISO and [64Cu]CuATSM

PET hypoxia imaging can assess tissue viability in acute ischemic stroke (AIS). [18F]FMISO is an established tracer but requires substantial accumulation time, limiting its use in hyperacute AIS. [64Cu]CuATSM requires less accumulation time and has shown promise as a hypoxia tracer. We compared thes...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2021-03, Vol.41 (3), p.617-629
Hauptverfasser:	Little, Philip V, Arnberg, Fabian, Jussing, Emma, Lu, Li, Ingemann Jensen, Andreas, Mitsios, Nicholas, Mulder, Jan, Tran, Thuy A, Holmin, Staffan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - chemistry Astrocytes - metabolism Autoradiography Brain - diagnostic imaging Brain Ischemia - metabolism Brain Ischemia - pathology Cerebellar Cortex - chemistry Cerebellar Cortex - diagnostic imaging Cerebellar Cortex - pathology Coordination Complexes Copper Radioisotopes - chemistry Disease Models, Animal Fluorine Radioisotopes - chemistry Hypoxia Male Misonidazole - analogs & derivatives Misonidazole - chemical synthesis Misonidazole - chemistry Neurons - chemistry Neurons - metabolism Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Original Positron-Emission Tomography Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Rats Rats, Sprague-Dawley Thiosemicarbazones - chemical synthesis Thiosemicarbazones - chemistry
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