Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification

RATIONALE:Vascular calcification, the formation of calcium phosphate crystals in the vessel wall, is mediated by vascular smooth muscle cells (VSMCs). However, the underlying molecular mechanisms remain elusive, precluding mechanism-based therapies. OBJECTIVE:Phenotypic switching denotes a loss of c...

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Veröffentlicht in:	Circulation research 2020-09, Vol.127 (7), p.911-927
Hauptverfasser:	Furmanik, Malgorzata, Chatrou, Martijn, van Gorp, Rick, Akbulut, Asim, Willems, Brecht, Schmidt, Harald, van Eys, Guillaume, Bochaton-Piallat, Marie-Luce, Proudfoot, Diane, Biessen, Erik, Hedin, Ulf, Perisic, Ljubica, Mees, Barend, Shanahan, Catherine, Reutelingsperger, Chris, Schurgers, Leon
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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