High-definition likelihood inference of genetic correlations across human complex traits

Genetic correlation is a central parameter for understanding shared genetic architecture between complex traits. By using summary statistics from genome-wide association studies (GWAS), linkage disequilibrium score regression (LDSC) was developed for unbiased estimation of genetic correlations. Alth...

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Veröffentlicht in:	Nature genetics 2020-08, Vol.52 (8), p.859-864
Hauptverfasser:	Ning, Zheng, Pawitan, Yudi, Shen, Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/43 631/114/794 631/208/205/2138 Accuracy Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Comparative analysis Efficiency Estimates Gene Function Genetic Predisposition to Disease - genetics Genetic research Genome-wide association studies Genome-Wide Association Study - methods Genomes Genomic analysis Genomics High definition High density lipoprotein Human Genetics Humans Identification methods Information processing Linkage disequilibrium Linkage Disequilibrium - genetics Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Methods Models, Genetic Normal distribution Phenotype Phenotypes Polymorphism, Single Nucleotide - genetics Regression analysis Sample size Simulation Statistics technical-report
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