Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine

Rhabdoid tumors are devastating pediatric cancers in need of improved therapies. We sought to identify small molecules that exhibit and efficacy against preclinical models of rhabdoid tumor. We screened eight rhabdoid tumor cell lines with 481 small molecules and compared their sensitivity with that...

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Veröffentlicht in:	Clinical cancer research 2020-09, Vol.26 (18), p.4995-5006
Hauptverfasser:	Howard, Thomas P, Oberlick, Elaine M, Rees, Matthew G, Arnoff, Taylor E, Pham, Minh-Tam, Brenan, Lisa, DoCarmo, Mariana, Hong, Andrew L, Kugener, Guillaume, Chou, Hsien-Chao, Drosos, Yiannis, Mathias, Kaeli M, Ramos, Pilar, Seashore-Ludlow, Brinton, Giacomelli, Andrew O, Wang, Xiaofeng, Freeman, 3rd, Burgess B, Blankenship, Kaley, Hoffmann, Lauren, Tiv, Hong L, Gokhale, Prafulla C, Johannessen, Cory M, Stewart, Elizabeth A, Schreiber, Stuart L, Hahn, William C, Roberts, Charles W M
Format:	Artikel
Sprache:	eng
Schlagworte:	Medicin och hälsovetenskap
Online-Zugang:	Volltext
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