Development of a chemical probe against NUDT15

The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides, but was later shown to hydrolyze the active thiopurine metabolites, 6-thio-(d)GTP, thereby dictating the clinical response of this standard-of-care treatment for leukemia and inflammatory diseases. Nonetheless,...

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Veröffentlicht in:	Nature chemical biology 2020-10, Vol.16 (10), p.1120-1128
Hauptverfasser:	Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C. K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1644 631/67 631/92/556 631/92/613 Binding Sites Biochemical Engineering Biochemistry Biochemistry and Molecular Biology Biokemi och molekylärbiologi Biologi Biological Sciences Biology Bioorganic Chemistry Biophysics Cell Biology Cell Line Chemistry Chemistry and Materials Science Chemistry/Food Science Drug Design Drug Development Enzymes Escherichia coli Health services Humans Hydrolase Inflammatory diseases Inorganic Pyrophosphatase - antagonists & inhibitors Inorganic Pyrophosphatase - genetics Inorganic Pyrophosphatase - metabolism Laboratories Lead compounds Leukemia Medical research Medicin och hälsovetenskap Metabolism Metabolites Models, Molecular Natural Sciences Naturvetenskap Nucleic acids Nucleotides Physiology Protein Binding Protein Conformation Pyrophosphatases - antagonists & inhibitors Pyrophosphatases - chemistry Pyrophosphatases - genetics Pyrophosphatases - metabolism Structure-Activity Relationship Thioguanine Toxicity
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