Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel K V 6.4 Subunit

By studying healthy women who do not request analgesia during their first delivery, we investigate genetic effects on labor pain. Such women have normal sensory and psychometric test results, except for significantly higher cuff pressure pain. We find an excess of heterozygotes carrying the rare all...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-07, Vol.32 (3), p.107941
Hauptverfasser:	Lee, Michael C, Nahorski, Michael S, Hockley, James R F, Lu, Van B, Ison, Gillian, Pattison, Luke A, Callejo, Gerard, Stouffer, Kaitlin, Fletcher, Emily, Brown, Christopher, Drissi, Ichrak, Wheeler, Daniel, Ernfors, Patrik, Menon, David, Reimann, Frank, Smith, Ewan St John, Woods, C Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Amino Acid Sequence Analgesics - pharmacology Animals Base Sequence Cell Membrane - metabolism Cognition Cohort Studies Emotions Female Ganglia, Spinal - metabolism Heterozygote Humans Ion Channel Gating - genetics Labor Pain - genetics Labor Pain - metabolism Labor Pain - physiopathology Male Mice, Inbred C57BL Models, Biological Mutation - genetics Nociceptors - metabolism Pain Threshold Polymorphism, Single Nucleotide - genetics Potassium Channels, Voltage-Gated - chemistry Potassium Channels, Voltage-Gated - genetics Potassium Channels, Voltage-Gated - metabolism Pregnancy Protein Multimerization Protein Subunits - metabolism Sensory Receptor Cells - metabolism Shab Potassium Channels - metabolism Subcellular Fractions - metabolism Uterus - innervation
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