Long-term whole-grain rye and wheat consumption and their associations with selected biomarkers of inflammation, endothelial function, and cardiovascular disease
Background/objectives Whole-grain (WG) intake has been associated with a lowered risk of developing type 2 diabetes, cardiovascular disease, and some cancers in epidemiological studies. Reduced subclinical inflammation could be one important mechanism behind such associations. This study investigate...
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| Veröffentlicht in: | European journal of clinical nutrition 2021-01, Vol.75 (1), p.123-132 |
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| creator | Mhd Omar, Nor Adila Wu, Huaxing Larsson, Anders Wolk, Alicja Landberg, Rikard |
| description | Background/objectives
Whole-grain (WG) intake has been associated with a lowered risk of developing type 2 diabetes, cardiovascular disease, and some cancers in epidemiological studies. Reduced subclinical inflammation could be one important mechanism behind such associations. This study investigated whether high long-term WG rye and wheat intakes were associated with lower concentrations of biomarkers of inflammation, endothelial function, and protein biomarkers associated with cardiovascular disease.
Subjects/methods
We assessed WG intake by food frequency questionnaire (FFQ) and by measuring alkylresorcinols (ARs) in plasma and adipose tissue, respectively. Selected biomarkers in free-living 109 women and 149 men were analyzed from two clinical subcohort studies (Swedish Mammography Cohort-Clinical (SMC-C) and Cohort of Swedish Men-Clinical (COSM-C), respectively. Total WG rye and wheat (WGRnW) and the ratio of WG rye to WG rye and wheat (WGR/WGRnW) were estimated from FFQs. ARs were measured in plasma and adipose tissue by gas chromatography-mass spectrometry (GC-MS) and the biomarkers by ELISA.
Results
We found no consistent associations between WG intake assessed by different methods and the selected biomarkers. However, WGRnW intake was inversely associated with cathepsin S (
P-trend
|
| doi_str_mv | 10.1038/s41430-020-00714-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_469012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A655716552</galeid><sourcerecordid>A655716552</sourcerecordid><originalsourceid>FETCH-LOGICAL-c750t-91cfbebcb39efccaed51e948aab47b104465db3b1b3880585cad2097a0299693</originalsourceid><addsrcrecordid>eNp9k8tu1TAQhiMEoqXwAiyQJSRWTbETJ46XVblKlVhQsbXG9vgct0l8sBOqPg5vis-lPVRqqygX_f7-yczYUxRvGT1htO4-Js54TUta5ZsKxsv6WXHIuGjLpuX0eXFIZZPFvHZQvErpktK8KKqXxUFdia6qu_aw-HsexkU5YRzI9TL0WC4i-JHEGyQw2qwhTMSEMc3DavJh3KjTEn0kkFIwHtZqItd-WpKEPZoJLdE-DBCvMCYSHPGj62EYNuQxwdGGHKD30BM3j2arrsMaiNaHP5DM3EMk1ieEhK-LFw76hG9276Pi4svni7Nv5fmPr9_PTs9LIxo6lZIZp1EbXUt0xgDahqHkHYDmQjPKedtYXWum666jTdcYsBWVAmglZSvro6Lchk3XuJq1WkWfS7hRAbzaSVf5CxVvJWVV5n8-ykfMmUezVGYJ_ZC7sPZpDYYZ61TV1lZxEFoBs1Y52aLrWto5x3JU-WjUVQx2n8ptOoxzznJGPHuPH_V-8r9OVYgLNc-KM9F29MmC9_gwKya45OuC32_5nMfvGdOkLsMcx7wlquJCsk6whu6pBfSo8s6HKYIZfDLqtG0awfKj2v_7HrXAESP0YUTns3yPP3mAz5fFwZsHDR_-M-RD3E_LFPp5c1jvg9UWNDGkFNHd9YFRtZ4ytZ0yladMbaZM1dn0bteKWQ9o7yy3Y5WBetfbvDQuMO579UTYfwMtNvg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2479187150</pqid></control><display><type>article</type><title>Long-term whole-grain rye and wheat consumption and their associations with selected biomarkers of inflammation, endothelial function, and cardiovascular disease</title><source>Alma/SFX Local Collection</source><creator>Mhd Omar, Nor Adila ; Wu, Huaxing ; Larsson, Anders ; Wolk, Alicja ; Landberg, Rikard</creator><creatorcontrib>Mhd Omar, Nor Adila ; Wu, Huaxing ; Larsson, Anders ; Wolk, Alicja ; Landberg, Rikard</creatorcontrib><description>Background/objectives
Whole-grain (WG) intake has been associated with a lowered risk of developing type 2 diabetes, cardiovascular disease, and some cancers in epidemiological studies. Reduced subclinical inflammation could be one important mechanism behind such associations. This study investigated whether high long-term WG rye and wheat intakes were associated with lower concentrations of biomarkers of inflammation, endothelial function, and protein biomarkers associated with cardiovascular disease.
Subjects/methods
We assessed WG intake by food frequency questionnaire (FFQ) and by measuring alkylresorcinols (ARs) in plasma and adipose tissue, respectively. Selected biomarkers in free-living 109 women and 149 men were analyzed from two clinical subcohort studies (Swedish Mammography Cohort-Clinical (SMC-C) and Cohort of Swedish Men-Clinical (COSM-C), respectively. Total WG rye and wheat (WGRnW) and the ratio of WG rye to WG rye and wheat (WGR/WGRnW) were estimated from FFQs. ARs were measured in plasma and adipose tissue by gas chromatography-mass spectrometry (GC-MS) and the biomarkers by ELISA.
Results
We found no consistent associations between WG intake assessed by different methods and the selected biomarkers. However, WGRnW intake was inversely associated with cathepsin S (
P-trend
< 0.05) and total AR and C17:0/C21:0 in plasma were inversely associated with the endostatin concentration (
P-trend
< 0.05) adjusted for BMI, age, and sex.
Conclusion
The results give limited support to the hypothesis that a high WG wheat and rye intake is associated with lower concentrations of common biomarkers of inflammation and CVD that have previously been reported inversely associated with WG intake or an overall healthy lifestyle.</description><identifier>ISSN: 0954-3007</identifier><identifier>ISSN: 1476-5640</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-020-00714-3</identifier><identifier>PMID: 32782386</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/700/2814 ; 692/700/478/174 ; Adipose tissue ; Analysis ; Biological markers ; Biomarkers ; Cardiovascular disease ; Cardiovascular diseases ; Cathepsin S ; Clinical Nutrition ; Diabetes mellitus (non-insulin dependent) ; Diagnosis ; Endostatin ; Epidemiology ; Food intake ; Gas chromatography ; Grain ; Health aspects ; Hälsovetenskap ; Inflammation ; Internal Medicine ; Kardiologi ; Klinisk medicin ; Mammography ; Mass spectrometry ; Mass spectroscopy ; Medicin och hälsovetenskap ; Medicine ; Medicine & Public Health ; Men ; Metabolic Diseases ; Näringslära ; Properties ; Public Health ; Rye ; Wheat</subject><ispartof>European journal of clinical nutrition, 2021-01, Vol.75 (1), p.123-132</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c750t-91cfbebcb39efccaed51e948aab47b104465db3b1b3880585cad2097a0299693</citedby><cites>FETCH-LOGICAL-c750t-91cfbebcb39efccaed51e948aab47b104465db3b1b3880585cad2097a0299693</cites><orcidid>0000-0003-3161-0402 ; 0000-0001-7387-6845</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32782386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174942$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-417680$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:144419014$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://research.chalmers.se/publication/518943$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Mhd Omar, Nor Adila</creatorcontrib><creatorcontrib>Wu, Huaxing</creatorcontrib><creatorcontrib>Larsson, Anders</creatorcontrib><creatorcontrib>Wolk, Alicja</creatorcontrib><creatorcontrib>Landberg, Rikard</creatorcontrib><title>Long-term whole-grain rye and wheat consumption and their associations with selected biomarkers of inflammation, endothelial function, and cardiovascular disease</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/objectives
Whole-grain (WG) intake has been associated with a lowered risk of developing type 2 diabetes, cardiovascular disease, and some cancers in epidemiological studies. Reduced subclinical inflammation could be one important mechanism behind such associations. This study investigated whether high long-term WG rye and wheat intakes were associated with lower concentrations of biomarkers of inflammation, endothelial function, and protein biomarkers associated with cardiovascular disease.
Subjects/methods
We assessed WG intake by food frequency questionnaire (FFQ) and by measuring alkylresorcinols (ARs) in plasma and adipose tissue, respectively. Selected biomarkers in free-living 109 women and 149 men were analyzed from two clinical subcohort studies (Swedish Mammography Cohort-Clinical (SMC-C) and Cohort of Swedish Men-Clinical (COSM-C), respectively. Total WG rye and wheat (WGRnW) and the ratio of WG rye to WG rye and wheat (WGR/WGRnW) were estimated from FFQs. ARs were measured in plasma and adipose tissue by gas chromatography-mass spectrometry (GC-MS) and the biomarkers by ELISA.
Results
We found no consistent associations between WG intake assessed by different methods and the selected biomarkers. However, WGRnW intake was inversely associated with cathepsin S (
P-trend
< 0.05) and total AR and C17:0/C21:0 in plasma were inversely associated with the endostatin concentration (
P-trend
< 0.05) adjusted for BMI, age, and sex.
Conclusion
The results give limited support to the hypothesis that a high WG wheat and rye intake is associated with lower concentrations of common biomarkers of inflammation and CVD that have previously been reported inversely associated with WG intake or an overall healthy lifestyle.</description><subject>692/700/2814</subject><subject>692/700/478/174</subject><subject>Adipose tissue</subject><subject>Analysis</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cathepsin S</subject><subject>Clinical Nutrition</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diagnosis</subject><subject>Endostatin</subject><subject>Epidemiology</subject><subject>Food intake</subject><subject>Gas chromatography</subject><subject>Grain</subject><subject>Health aspects</subject><subject>Hälsovetenskap</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Kardiologi</subject><subject>Klinisk medicin</subject><subject>Mammography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Men</subject><subject>Metabolic Diseases</subject><subject>Näringslära</subject><subject>Properties</subject><subject>Public Health</subject><subject>Rye</subject><subject>Wheat</subject><issn>0954-3007</issn><issn>1476-5640</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9k8tu1TAQhiMEoqXwAiyQJSRWTbETJ46XVblKlVhQsbXG9vgct0l8sBOqPg5vis-lPVRqqygX_f7-yczYUxRvGT1htO4-Js54TUta5ZsKxsv6WXHIuGjLpuX0eXFIZZPFvHZQvErpktK8KKqXxUFdia6qu_aw-HsexkU5YRzI9TL0WC4i-JHEGyQw2qwhTMSEMc3DavJh3KjTEn0kkFIwHtZqItd-WpKEPZoJLdE-DBCvMCYSHPGj62EYNuQxwdGGHKD30BM3j2arrsMaiNaHP5DM3EMk1ieEhK-LFw76hG9276Pi4svni7Nv5fmPr9_PTs9LIxo6lZIZp1EbXUt0xgDahqHkHYDmQjPKedtYXWum666jTdcYsBWVAmglZSvro6Lchk3XuJq1WkWfS7hRAbzaSVf5CxVvJWVV5n8-ykfMmUezVGYJ_ZC7sPZpDYYZ61TV1lZxEFoBs1Y52aLrWto5x3JU-WjUVQx2n8ptOoxzznJGPHuPH_V-8r9OVYgLNc-KM9F29MmC9_gwKya45OuC32_5nMfvGdOkLsMcx7wlquJCsk6whu6pBfSo8s6HKYIZfDLqtG0awfKj2v_7HrXAESP0YUTns3yPP3mAz5fFwZsHDR_-M-RD3E_LFPp5c1jvg9UWNDGkFNHd9YFRtZ4ytZ0yladMbaZM1dn0bteKWQ9o7yy3Y5WBetfbvDQuMO579UTYfwMtNvg</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Mhd Omar, Nor Adila</creator><creator>Wu, Huaxing</creator><creator>Larsson, Anders</creator><creator>Wolk, Alicja</creator><creator>Landberg, Rikard</creator><general>Nature Publishing Group UK</general><general>Nature Publishing 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whole-grain rye and wheat consumption and their associations with selected biomarkers of inflammation, endothelial function, and cardiovascular disease</title><author>Mhd Omar, Nor Adila ; Wu, Huaxing ; Larsson, Anders ; Wolk, Alicja ; Landberg, Rikard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c750t-91cfbebcb39efccaed51e948aab47b104465db3b1b3880585cad2097a0299693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/700/2814</topic><topic>692/700/478/174</topic><topic>Adipose tissue</topic><topic>Analysis</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cathepsin S</topic><topic>Clinical Nutrition</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diagnosis</topic><topic>Endostatin</topic><topic>Epidemiology</topic><topic>Food intake</topic><topic>Gas chromatography</topic><topic>Grain</topic><topic>Health aspects</topic><topic>Hälsovetenskap</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Kardiologi</topic><topic>Klinisk medicin</topic><topic>Mammography</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medicin och hälsovetenskap</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Men</topic><topic>Metabolic Diseases</topic><topic>Näringslära</topic><topic>Properties</topic><topic>Public Health</topic><topic>Rye</topic><topic>Wheat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mhd Omar, Nor Adila</creatorcontrib><creatorcontrib>Wu, Huaxing</creatorcontrib><creatorcontrib>Larsson, Anders</creatorcontrib><creatorcontrib>Wolk, Alicja</creatorcontrib><creatorcontrib>Landberg, Rikard</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central 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Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Chalmers tekniska högskola</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mhd Omar, Nor Adila</au><au>Wu, Huaxing</au><au>Larsson, Anders</au><au>Wolk, Alicja</au><au>Landberg, Rikard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term whole-grain rye and wheat consumption and their associations with selected biomarkers of inflammation, endothelial function, and cardiovascular disease</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>75</volume><issue>1</issue><spage>123</spage><epage>132</epage><pages>123-132</pages><issn>0954-3007</issn><issn>1476-5640</issn><eissn>1476-5640</eissn><abstract>Background/objectives
Whole-grain (WG) intake has been associated with a lowered risk of developing type 2 diabetes, cardiovascular disease, and some cancers in epidemiological studies. Reduced subclinical inflammation could be one important mechanism behind such associations. This study investigated whether high long-term WG rye and wheat intakes were associated with lower concentrations of biomarkers of inflammation, endothelial function, and protein biomarkers associated with cardiovascular disease.
Subjects/methods
We assessed WG intake by food frequency questionnaire (FFQ) and by measuring alkylresorcinols (ARs) in plasma and adipose tissue, respectively. Selected biomarkers in free-living 109 women and 149 men were analyzed from two clinical subcohort studies (Swedish Mammography Cohort-Clinical (SMC-C) and Cohort of Swedish Men-Clinical (COSM-C), respectively. Total WG rye and wheat (WGRnW) and the ratio of WG rye to WG rye and wheat (WGR/WGRnW) were estimated from FFQs. ARs were measured in plasma and adipose tissue by gas chromatography-mass spectrometry (GC-MS) and the biomarkers by ELISA.
Results
We found no consistent associations between WG intake assessed by different methods and the selected biomarkers. However, WGRnW intake was inversely associated with cathepsin S (
P-trend
< 0.05) and total AR and C17:0/C21:0 in plasma were inversely associated with the endostatin concentration (
P-trend
< 0.05) adjusted for BMI, age, and sex.
Conclusion
The results give limited support to the hypothesis that a high WG wheat and rye intake is associated with lower concentrations of common biomarkers of inflammation and CVD that have previously been reported inversely associated with WG intake or an overall healthy lifestyle.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32782386</pmid><doi>10.1038/s41430-020-00714-3</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-3161-0402</orcidid><orcidid>https://orcid.org/0000-0001-7387-6845</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of clinical nutrition, 2021-01, Vol.75 (1), p.123-132 |
| issn | 0954-3007 1476-5640 1476-5640 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | 692/700/2814 692/700/478/174 Adipose tissue Analysis Biological markers Biomarkers Cardiovascular disease Cardiovascular diseases Cathepsin S Clinical Nutrition Diabetes mellitus (non-insulin dependent) Diagnosis Endostatin Epidemiology Food intake Gas chromatography Grain Health aspects Hälsovetenskap Inflammation Internal Medicine Kardiologi Klinisk medicin Mammography Mass spectrometry Mass spectroscopy Medicin och hälsovetenskap Medicine Medicine & Public Health Men Metabolic Diseases Näringslära Properties Public Health Rye Wheat |
| title | Long-term whole-grain rye and wheat consumption and their associations with selected biomarkers of inflammation, endothelial function, and cardiovascular disease |
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