Travel-related hepatitis E: a two-decade GeoSentinel analysis
Abstract Background Hepatitis E virus (HEV) is widely distributed worldwide and is endemic in developing countries. Travel-related HEV infection has been reported at national levels, but global data are missing. Moreover, the global availability of HEV diagnostic testing has not been explored so far...
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| Veröffentlicht in: | Journal of travel medicine 2020-11, Vol.27 (7) |
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| creator | Nicolini, Laura Ambra P Stoney, Rhett J Della Vecchia, Andrea Grobusch, Martin Gautret, Philippe Angelo, Kristina M van Genderen, Perry J J Bottieau, Emmanuel Leder, Karin Asgeirsson, Hilmir Leung, Daniel T Connor, Bradley Pandey, Prativa Toscanini, Federica Gobbi, Federico Castelli, Francesco Bassetti, Matteo Hamer, Davidson H |
| description | Abstract
Background
Hepatitis E virus (HEV) is widely distributed worldwide and is endemic in developing countries. Travel-related HEV infection has been reported at national levels, but global data are missing. Moreover, the global availability of HEV diagnostic testing has not been explored so far. The aim of this study is to describe the epidemiology of HEV infections in returning travellers and availability of HEV diagnostic testing in the GeoSentinel surveillance network.
Methods
This was a multicentre retrospective cross-sectional study. All confirmed and probable HEV travel-related infections reported in the GeoSentinel Network between 1999 and 2018 were evaluated. GeoSentinel sites were asked to complete a survey in 2018 to assess the availability and accessibility of HEV diagnostic procedures (i.e. serology and molecular tests) throughout the study period.
Results
Overall, 165 travel-related HEV infections were reported, mainly since 2010 (60%) and in tourists (50%). Travellers were exposed to hepatitis E in 27 countries; most travellers (62%) were exposed to HEV in South Asia. One patient was pregnant at the time of HEV infection and 14 had a concomitant gastrointestinal infection. No deaths were reported. In the 51% of patients with information available, there was no pre-travel consultation. Among 44 GeoSentinel sites that responded to the survey, 73% have access to HEV serology at a local level, while 55% could perform (at a local or central level) molecular diagnostics.
Conclusion
Reported access to HEV diagnostic testing is suboptimal among sites that responded to the survey; this could negatively affect diagnosing HEV. Pre-travel consultations before travel to South Asia and other low-income and high-prevalence areas with a focus on food and water precautions could be helpful in preventing hepatitis E infection. Improved HEV diagnostic capacity should be implemented to prevent and correctly diagnose travel-related HEV infection. |
| doi_str_mv | 10.1093/jtm/taaa132 |
| format | Article |
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Background
Hepatitis E virus (HEV) is widely distributed worldwide and is endemic in developing countries. Travel-related HEV infection has been reported at national levels, but global data are missing. Moreover, the global availability of HEV diagnostic testing has not been explored so far. The aim of this study is to describe the epidemiology of HEV infections in returning travellers and availability of HEV diagnostic testing in the GeoSentinel surveillance network.
Methods
This was a multicentre retrospective cross-sectional study. All confirmed and probable HEV travel-related infections reported in the GeoSentinel Network between 1999 and 2018 were evaluated. GeoSentinel sites were asked to complete a survey in 2018 to assess the availability and accessibility of HEV diagnostic procedures (i.e. serology and molecular tests) throughout the study period.
Results
Overall, 165 travel-related HEV infections were reported, mainly since 2010 (60%) and in tourists (50%). Travellers were exposed to hepatitis E in 27 countries; most travellers (62%) were exposed to HEV in South Asia. One patient was pregnant at the time of HEV infection and 14 had a concomitant gastrointestinal infection. No deaths were reported. In the 51% of patients with information available, there was no pre-travel consultation. Among 44 GeoSentinel sites that responded to the survey, 73% have access to HEV serology at a local level, while 55% could perform (at a local or central level) molecular diagnostics.
Conclusion
Reported access to HEV diagnostic testing is suboptimal among sites that responded to the survey; this could negatively affect diagnosing HEV. Pre-travel consultations before travel to South Asia and other low-income and high-prevalence areas with a focus on food and water precautions could be helpful in preventing hepatitis E infection. Improved HEV diagnostic capacity should be implemented to prevent and correctly diagnose travel-related HEV infection.</description><identifier>ISSN: 1195-1982</identifier><identifier>EISSN: 1708-8305</identifier><identifier>DOI: 10.1093/jtm/taaa132</identifier><identifier>PMID: 32789467</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Accident prevention ; Availability ; Bacteriology ; Cardiology and cardiovascular system ; Developing countries ; Diagnostic systems ; Diagnostic tests ; Emerging diseases ; Epidemiology ; Hepatitis ; Human health and pathology ; Infections ; Infectious diseases ; LDCs ; Life Sciences ; Microbiology and Parasitology ; Parasitology ; Polls & surveys ; Serology ; Tourists ; Travel ; Travellers ; Virology ; Viruses</subject><ispartof>Journal of travel medicine, 2020-11, Vol.27 (7)</ispartof><rights>International Society of Travel Medicine 2020. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2020</rights><rights>International Society of Travel Medicine 2020. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-6e4c500a933db1142f865d4c4772602e4ed006690c54efc41764cfbad7ccada63</citedby><cites>FETCH-LOGICAL-c489t-6e4c500a933db1142f865d4c4772602e4ed006690c54efc41764cfbad7ccada63</cites><orcidid>0000-0002-4538-1463 ; 0000-0002-4700-1495 ; 0000-0001-8401-0801 ; 0000-0002-1664-958X ; 0000-0002-4126-9167 ; 0000-0002-9360-6233</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,1578,27903,27904</link.rule.ids><backlink>$$Uhttps://amu.hal.science/hal-03165151$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:145362881$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nicolini, Laura Ambra P</creatorcontrib><creatorcontrib>Stoney, Rhett J</creatorcontrib><creatorcontrib>Della Vecchia, Andrea</creatorcontrib><creatorcontrib>Grobusch, Martin</creatorcontrib><creatorcontrib>Gautret, Philippe</creatorcontrib><creatorcontrib>Angelo, Kristina M</creatorcontrib><creatorcontrib>van Genderen, Perry J J</creatorcontrib><creatorcontrib>Bottieau, Emmanuel</creatorcontrib><creatorcontrib>Leder, Karin</creatorcontrib><creatorcontrib>Asgeirsson, Hilmir</creatorcontrib><creatorcontrib>Leung, Daniel T</creatorcontrib><creatorcontrib>Connor, Bradley</creatorcontrib><creatorcontrib>Pandey, Prativa</creatorcontrib><creatorcontrib>Toscanini, Federica</creatorcontrib><creatorcontrib>Gobbi, Federico</creatorcontrib><creatorcontrib>Castelli, Francesco</creatorcontrib><creatorcontrib>Bassetti, Matteo</creatorcontrib><creatorcontrib>Hamer, Davidson H</creatorcontrib><title>Travel-related hepatitis E: a two-decade GeoSentinel analysis</title><title>Journal of travel medicine</title><description>Abstract
Background
Hepatitis E virus (HEV) is widely distributed worldwide and is endemic in developing countries. Travel-related HEV infection has been reported at national levels, but global data are missing. Moreover, the global availability of HEV diagnostic testing has not been explored so far. The aim of this study is to describe the epidemiology of HEV infections in returning travellers and availability of HEV diagnostic testing in the GeoSentinel surveillance network.
Methods
This was a multicentre retrospective cross-sectional study. All confirmed and probable HEV travel-related infections reported in the GeoSentinel Network between 1999 and 2018 were evaluated. GeoSentinel sites were asked to complete a survey in 2018 to assess the availability and accessibility of HEV diagnostic procedures (i.e. serology and molecular tests) throughout the study period.
Results
Overall, 165 travel-related HEV infections were reported, mainly since 2010 (60%) and in tourists (50%). Travellers were exposed to hepatitis E in 27 countries; most travellers (62%) were exposed to HEV in South Asia. One patient was pregnant at the time of HEV infection and 14 had a concomitant gastrointestinal infection. No deaths were reported. In the 51% of patients with information available, there was no pre-travel consultation. Among 44 GeoSentinel sites that responded to the survey, 73% have access to HEV serology at a local level, while 55% could perform (at a local or central level) molecular diagnostics.
Conclusion
Reported access to HEV diagnostic testing is suboptimal among sites that responded to the survey; this could negatively affect diagnosing HEV. Pre-travel consultations before travel to South Asia and other low-income and high-prevalence areas with a focus on food and water precautions could be helpful in preventing hepatitis E infection. Improved HEV diagnostic capacity should be implemented to prevent and correctly diagnose travel-related HEV infection.</description><subject>Accident prevention</subject><subject>Availability</subject><subject>Bacteriology</subject><subject>Cardiology and cardiovascular system</subject><subject>Developing countries</subject><subject>Diagnostic systems</subject><subject>Diagnostic tests</subject><subject>Emerging diseases</subject><subject>Epidemiology</subject><subject>Hepatitis</subject><subject>Human health and pathology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>LDCs</subject><subject>Life Sciences</subject><subject>Microbiology and Parasitology</subject><subject>Parasitology</subject><subject>Polls & surveys</subject><subject>Serology</subject><subject>Tourists</subject><subject>Travel</subject><subject>Travellers</subject><subject>Virology</subject><subject>Viruses</subject><issn>1195-1982</issn><issn>1708-8305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>D8T</sourceid><recordid>eNp9kd9rFDEQx4NYbK0--Q8sCFKRtfmdjVChlP4QDnywPoe57Ky3597mTLJX-t-bYw-hffApw8xnvjOTLyHvGP3MqBXn67w5zwDABH9BTpihTd0Iql6WmFlVM9vwY_I6pTWllDecvyLHgpvGSm1OyMV9hB0OdcQBMrbVCreQ-9yn6vpLBVV-CHWLHlqsbjH8wDH3Iw4VjDA8pj69IUcdDAnfHt5T8vPm-v7qrl58v_12dbmovWxsrjVKrygFK0S7ZEzyrtGqlV4awzXlKLGlVGtLvZLYecmMlr5bQmt8GQ1anJJ61k0PuJ2Wbhv7DcRHF6B3h9TvEqGTurGGF_7rzJfKBltf9o4wPGl7Whn7lfsVds5KK5USReDjLLB61nZ3uXD7HBVMK6bYjhX27DAshj8Tpuw2ffI4DDBimJLjUkiqy9WqoO-foeswxfKZe8oIo41W-2s_zZSPIaWI3b8NGHV7y12x3B0sL_SHmQ7T9r_gXyczqsk</recordid><startdate>20201109</startdate><enddate>20201109</enddate><creator>Nicolini, 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hepatitis E: a two-decade GeoSentinel analysis</title><author>Nicolini, Laura Ambra P ; Stoney, Rhett J ; Della Vecchia, Andrea ; Grobusch, Martin ; Gautret, Philippe ; Angelo, Kristina M ; van Genderen, Perry J J ; Bottieau, Emmanuel ; Leder, Karin ; Asgeirsson, Hilmir ; Leung, Daniel T ; Connor, Bradley ; Pandey, Prativa ; Toscanini, Federica ; Gobbi, Federico ; Castelli, Francesco ; Bassetti, Matteo ; Hamer, Davidson H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-6e4c500a933db1142f865d4c4772602e4ed006690c54efc41764cfbad7ccada63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Accident prevention</topic><topic>Availability</topic><topic>Bacteriology</topic><topic>Cardiology and cardiovascular system</topic><topic>Developing countries</topic><topic>Diagnostic systems</topic><topic>Diagnostic tests</topic><topic>Emerging diseases</topic><topic>Epidemiology</topic><topic>Hepatitis</topic><topic>Human health and pathology</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>LDCs</topic><topic>Life Sciences</topic><topic>Microbiology and Parasitology</topic><topic>Parasitology</topic><topic>Polls & surveys</topic><topic>Serology</topic><topic>Tourists</topic><topic>Travel</topic><topic>Travellers</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nicolini, Laura Ambra P</creatorcontrib><creatorcontrib>Stoney, Rhett J</creatorcontrib><creatorcontrib>Della Vecchia, Andrea</creatorcontrib><creatorcontrib>Grobusch, Martin</creatorcontrib><creatorcontrib>Gautret, Philippe</creatorcontrib><creatorcontrib>Angelo, Kristina M</creatorcontrib><creatorcontrib>van Genderen, Perry J J</creatorcontrib><creatorcontrib>Bottieau, Emmanuel</creatorcontrib><creatorcontrib>Leder, 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Kristina M</au><au>van Genderen, Perry J J</au><au>Bottieau, Emmanuel</au><au>Leder, Karin</au><au>Asgeirsson, Hilmir</au><au>Leung, Daniel T</au><au>Connor, Bradley</au><au>Pandey, Prativa</au><au>Toscanini, Federica</au><au>Gobbi, Federico</au><au>Castelli, Francesco</au><au>Bassetti, Matteo</au><au>Hamer, Davidson H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Travel-related hepatitis E: a two-decade GeoSentinel analysis</atitle><jtitle>Journal of travel medicine</jtitle><date>2020-11-09</date><risdate>2020</risdate><volume>27</volume><issue>7</issue><issn>1195-1982</issn><eissn>1708-8305</eissn><abstract>Abstract
Background
Hepatitis E virus (HEV) is widely distributed worldwide and is endemic in developing countries. Travel-related HEV infection has been reported at national levels, but global data are missing. Moreover, the global availability of HEV diagnostic testing has not been explored so far. The aim of this study is to describe the epidemiology of HEV infections in returning travellers and availability of HEV diagnostic testing in the GeoSentinel surveillance network.
Methods
This was a multicentre retrospective cross-sectional study. All confirmed and probable HEV travel-related infections reported in the GeoSentinel Network between 1999 and 2018 were evaluated. GeoSentinel sites were asked to complete a survey in 2018 to assess the availability and accessibility of HEV diagnostic procedures (i.e. serology and molecular tests) throughout the study period.
Results
Overall, 165 travel-related HEV infections were reported, mainly since 2010 (60%) and in tourists (50%). Travellers were exposed to hepatitis E in 27 countries; most travellers (62%) were exposed to HEV in South Asia. One patient was pregnant at the time of HEV infection and 14 had a concomitant gastrointestinal infection. No deaths were reported. In the 51% of patients with information available, there was no pre-travel consultation. Among 44 GeoSentinel sites that responded to the survey, 73% have access to HEV serology at a local level, while 55% could perform (at a local or central level) molecular diagnostics.
Conclusion
Reported access to HEV diagnostic testing is suboptimal among sites that responded to the survey; this could negatively affect diagnosing HEV. Pre-travel consultations before travel to South Asia and other low-income and high-prevalence areas with a focus on food and water precautions could be helpful in preventing hepatitis E infection. Improved HEV diagnostic capacity should be implemented to prevent and correctly diagnose travel-related HEV infection.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>32789467</pmid><doi>10.1093/jtm/taaa132</doi><orcidid>https://orcid.org/0000-0002-4538-1463</orcidid><orcidid>https://orcid.org/0000-0002-4700-1495</orcidid><orcidid>https://orcid.org/0000-0001-8401-0801</orcidid><orcidid>https://orcid.org/0000-0002-1664-958X</orcidid><orcidid>https://orcid.org/0000-0002-4126-9167</orcidid><orcidid>https://orcid.org/0000-0002-9360-6233</orcidid><oa>free_for_read</oa></addata></record> |
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| source | SWEPUB Freely available online; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Accident prevention Availability Bacteriology Cardiology and cardiovascular system Developing countries Diagnostic systems Diagnostic tests Emerging diseases Epidemiology Hepatitis Human health and pathology Infections Infectious diseases LDCs Life Sciences Microbiology and Parasitology Parasitology Polls & surveys Serology Tourists Travel Travellers Virology Viruses |
| title | Travel-related hepatitis E: a two-decade GeoSentinel analysis |
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