Radiation Therapy–Induced Changes of the Nasopharyngeal Commensal Microbiome in Nasopharyngeal Carcinoma Patients
The human commensal microbiome has been suggested to be involved in the regulation of response to anticancer therapies. However, little is known regarding changes in commensal microbes in patients with cancer during radiation therapy. We conducted a prospective, longitudinal proof-of-concept cohort...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2021-01, Vol.109 (1), p.145-150 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Huang, Tingting Debelius, Justine W. Ploner, Alexander Xiao, Xiling Zhang, Tingting Hu, Kai Zhang, Zhe Wang, Rensheng Ye, Weimin |
| description | The human commensal microbiome has been suggested to be involved in the regulation of response to anticancer therapies. However, little is known regarding changes in commensal microbes in patients with cancer during radiation therapy. We conducted a prospective, longitudinal proof-of-concept cohort study with patients with newly diagnosed nasopharyngeal carcinoma (NPC) who underwent radiation therapy-based treatment.
Nasopharyngeal swabs were collected before radiation therapy, twice per week during radiation therapy, and after radiation therapy. The nasopharyngeal microbiome was assessed using 16S rRNA amplicon sequencing. A patient’s response to treatment was measured 3 months after the completion of radiation therapy as a short-term clinical outcome. In total, 39 NPC patients with 445 nasopharyngeal samples were analyzed.
There was stable temporal change in the community structure of the nasopharyngeal microbiome among patients with NPC during treatment (P = .0005). Among 73 abundant amplicon sequence variants (ASVs), 7 ASVs assigned to genus Corynebacterium decreased significantly during the treatment (W-statistic >80%); 23 ASVs showed statistically significant changes in the ratio of abundance between early and late responders during treatment (false discovery rate |
| doi_str_mv | 10.1016/j.ijrobp.2020.08.054 |
| format | Article |
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Nasopharyngeal swabs were collected before radiation therapy, twice per week during radiation therapy, and after radiation therapy. The nasopharyngeal microbiome was assessed using 16S rRNA amplicon sequencing. A patient’s response to treatment was measured 3 months after the completion of radiation therapy as a short-term clinical outcome. In total, 39 NPC patients with 445 nasopharyngeal samples were analyzed.
There was stable temporal change in the community structure of the nasopharyngeal microbiome among patients with NPC during treatment (P = .0005). Among 73 abundant amplicon sequence variants (ASVs), 7 ASVs assigned to genus Corynebacterium decreased significantly during the treatment (W-statistic >80%); 23 ASVs showed statistically significant changes in the ratio of abundance between early and late responders during treatment (false discovery rate <0.05).
This study addressed stable temporal change in the nasopharyngeal microbiome among patients with NPC during radiation therapy–based treatment and provided preliminary evidence of an association with a short-term clinical outcome.</description><identifier>ISSN: 0360-3016</identifier><identifier>ISSN: 1879-355X</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2020.08.054</identifier><identifier>PMID: 32866565</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>CARCINOMAS ; DIAGNOSIS ; Medicin och hälsovetenskap ; PATIENTS ; PHARYNX ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY</subject><ispartof>International journal of radiation oncology, biology, physics, 2021-01, Vol.109 (1), p.145-150</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-fa870eb9c485595098ccca6ae1c947a9649dcbb5f7274c30702bb3471a828f083</citedby><cites>FETCH-LOGICAL-c524t-fa870eb9c485595098ccca6ae1c947a9649dcbb5f7274c30702bb3471a828f083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,552,780,885</link.rule.ids><linktorsrc>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:145510043$$EView_record_in_Swedish_Publication_Index_(SWEPUB)$$FView_record_in_$$GSwedish_Publication_Index_(SWEPUB)$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32866565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/23198713$$D View this record in Osti.gov$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:145510043$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Tingting</creatorcontrib><creatorcontrib>Debelius, Justine W.</creatorcontrib><creatorcontrib>Ploner, Alexander</creatorcontrib><creatorcontrib>Xiao, Xiling</creatorcontrib><creatorcontrib>Zhang, Tingting</creatorcontrib><creatorcontrib>Hu, Kai</creatorcontrib><creatorcontrib>Zhang, Zhe</creatorcontrib><creatorcontrib>Wang, Rensheng</creatorcontrib><creatorcontrib>Ye, Weimin</creatorcontrib><title>Radiation Therapy–Induced Changes of the Nasopharyngeal Commensal Microbiome in Nasopharyngeal Carcinoma Patients</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>The human commensal microbiome has been suggested to be involved in the regulation of response to anticancer therapies. However, little is known regarding changes in commensal microbes in patients with cancer during radiation therapy. We conducted a prospective, longitudinal proof-of-concept cohort study with patients with newly diagnosed nasopharyngeal carcinoma (NPC) who underwent radiation therapy-based treatment.
Nasopharyngeal swabs were collected before radiation therapy, twice per week during radiation therapy, and after radiation therapy. The nasopharyngeal microbiome was assessed using 16S rRNA amplicon sequencing. A patient’s response to treatment was measured 3 months after the completion of radiation therapy as a short-term clinical outcome. In total, 39 NPC patients with 445 nasopharyngeal samples were analyzed.
There was stable temporal change in the community structure of the nasopharyngeal microbiome among patients with NPC during treatment (P = .0005). Among 73 abundant amplicon sequence variants (ASVs), 7 ASVs assigned to genus Corynebacterium decreased significantly during the treatment (W-statistic >80%); 23 ASVs showed statistically significant changes in the ratio of abundance between early and late responders during treatment (false discovery rate <0.05).
This study addressed stable temporal change in the nasopharyngeal microbiome among patients with NPC during radiation therapy–based treatment and provided preliminary evidence of an association with a short-term clinical outcome.</description><subject>CARCINOMAS</subject><subject>DIAGNOSIS</subject><subject>Medicin och hälsovetenskap</subject><subject>PATIENTS</subject><subject>PHARYNX</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><issn>0360-3016</issn><issn>1879-355X</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>D8T</sourceid><recordid>eNp9ks1u1DAQxyMEokvhDRCKxIVLwvgrsS9IaAW0UvkQKhI3y3EmrJeNHeIE1BvvwBv2SXCUbTkgOHk0_v1n_pqZLHtMoCRAquf70u3H0AwlBQolyBIEv5NtiKxVwYT4fDfbAKugYAk-yR7EuAcAQmp-PzthVFaVqMQmix9N68zkgs8vdzia4er6569z384W23y7M_4Lxjx0-bTD_J2JYdiZ8SolzSHfhr5HH1P01tnkxIUec-f_wsxonQ-9yT-kPuin-DC715lDxEfH9zT79PrV5fasuHj_5nz78qKwgvKp6IysARtluRRCCVDSWmsqg8QqXhtVcdXaphFdTWtuGdRAm4bxmhhJZQeSnWbFWjf-wGFu9DC6PtnSwTh9TH1NEWpeScFp4tU_-WEM7R_RjZBwIQgAZ0n7dNWGOKUv6ya0Oxu8RztpyoiSNVmoZyuVyn2bMU66d9Hi4WA8hjlqypmqKJFyQfmKptHGOGJ3a4eAXg5A7_V6AHo5AA1SpwNIsifHDnPTY3srutl4Al6sAKbJf3c4LmbRp3W7cfHaBvf_Dr8B1O7G4w</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Huang, Tingting</creator><creator>Debelius, Justine W.</creator><creator>Ploner, Alexander</creator><creator>Xiao, Xiling</creator><creator>Zhang, Tingting</creator><creator>Hu, Kai</creator><creator>Zhang, Zhe</creator><creator>Wang, Rensheng</creator><creator>Ye, Weimin</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20210101</creationdate><title>Radiation Therapy–Induced Changes of the Nasopharyngeal Commensal Microbiome in Nasopharyngeal Carcinoma Patients</title><author>Huang, Tingting ; Debelius, Justine W. ; Ploner, Alexander ; Xiao, Xiling ; Zhang, Tingting ; Hu, Kai ; Zhang, Zhe ; Wang, Rensheng ; Ye, Weimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-fa870eb9c485595098ccca6ae1c947a9649dcbb5f7274c30702bb3471a828f083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>CARCINOMAS</topic><topic>DIAGNOSIS</topic><topic>Medicin och hälsovetenskap</topic><topic>PATIENTS</topic><topic>PHARYNX</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Tingting</creatorcontrib><creatorcontrib>Debelius, Justine W.</creatorcontrib><creatorcontrib>Ploner, Alexander</creatorcontrib><creatorcontrib>Xiao, Xiling</creatorcontrib><creatorcontrib>Zhang, Tingting</creatorcontrib><creatorcontrib>Hu, Kai</creatorcontrib><creatorcontrib>Zhang, Zhe</creatorcontrib><creatorcontrib>Wang, Rensheng</creatorcontrib><creatorcontrib>Ye, Weimin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Huang, Tingting</au><au>Debelius, Justine W.</au><au>Ploner, Alexander</au><au>Xiao, Xiling</au><au>Zhang, Tingting</au><au>Hu, Kai</au><au>Zhang, Zhe</au><au>Wang, Rensheng</au><au>Ye, Weimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation Therapy–Induced Changes of the Nasopharyngeal Commensal Microbiome in Nasopharyngeal Carcinoma Patients</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>109</volume><issue>1</issue><spage>145</spage><epage>150</epage><pages>145-150</pages><issn>0360-3016</issn><issn>1879-355X</issn><eissn>1879-355X</eissn><abstract>The human commensal microbiome has been suggested to be involved in the regulation of response to anticancer therapies. However, little is known regarding changes in commensal microbes in patients with cancer during radiation therapy. We conducted a prospective, longitudinal proof-of-concept cohort study with patients with newly diagnosed nasopharyngeal carcinoma (NPC) who underwent radiation therapy-based treatment.
Nasopharyngeal swabs were collected before radiation therapy, twice per week during radiation therapy, and after radiation therapy. The nasopharyngeal microbiome was assessed using 16S rRNA amplicon sequencing. A patient’s response to treatment was measured 3 months after the completion of radiation therapy as a short-term clinical outcome. In total, 39 NPC patients with 445 nasopharyngeal samples were analyzed.
There was stable temporal change in the community structure of the nasopharyngeal microbiome among patients with NPC during treatment (P = .0005). Among 73 abundant amplicon sequence variants (ASVs), 7 ASVs assigned to genus Corynebacterium decreased significantly during the treatment (W-statistic >80%); 23 ASVs showed statistically significant changes in the ratio of abundance between early and late responders during treatment (false discovery rate <0.05).
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| subjects | CARCINOMAS DIAGNOSIS Medicin och hälsovetenskap PATIENTS PHARYNX RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY |
| title | Radiation Therapy–Induced Changes of the Nasopharyngeal Commensal Microbiome in Nasopharyngeal Carcinoma Patients |
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