Diagnostic utility of right atrial reservoir strain to identify elevated right atrial pressure in heart failure

Diagnostic utility of right atrial reservoir strain to identify elevated right atrial pressure in heart failure

Accurate non-invasive estimation of right atrial pressure (RAP) is essential to assess volume status and optimize therapy in heart failure (HF). This study aimed to evaluate the utility of right atrial reservoir strain (RASr) assessed by speckle-tracking echocardiography to identify elevated RAP in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of cardiology 2021-02, Vol.324, p.227-232
Hauptverfasser: Miah, Nabilah, Faxén, Ulrika Ljung, Lund, Lars H., Venkateshvaran, Ashwin
Format: Artikel
Sprache:eng
Schlagworte:
Central venous pressure
Haemodynamics
Heart failure
Speckle tracking echocardiography
Strain imaging
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 232
container_issue
container_start_page 227
container_title International journal of cardiology
container_volume 324
creator Miah, Nabilah
Faxén, Ulrika Ljung
Lund, Lars H.
Venkateshvaran, Ashwin
description Accurate non-invasive estimation of right atrial pressure (RAP) is essential to assess volume status and optimize therapy in heart failure (HF). This study aimed to evaluate the utility of right atrial reservoir strain (RASr) assessed by speckle-tracking echocardiography to identify elevated RAP in HF and compare diagnostic performance with estimated RAP employing inferior vena cava size and collapsibility (RAPIVC), in addition to RA area. Association between RASr and invasive RAP (RAPInvasive) was examined in 103 HF subjects that underwent standard echocardiography with speckle-tracking strain analysis directly followed by right heart catheterization. The discriminatory ability of RASr to identify RAPInvasive > 7 mmHg was evaluated and compared with RAPIVC and RA area. RASr demonstrated association with RAPInvasive (β = −0.41, p 
doi_str_mv 10.1016/j.ijcard.2020.09.008
format Article
fullrecord <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_468086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167527320337426</els_id><sourcerecordid>2444378329</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-347948db685eba561d75ec4622bae219cd21aaf83f42fe66253da8507dc478133</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhi0EotvCGyDkI5ektuPEzgUJtUArVeoFzpZjT9pZsvFiO1vt2-MqSyUunGY0-v4ZaT5CPnBWc8a7y22NW2ejrwUTrGZ9zZh-RTZcK1lx1crXZFMwVbVCNWfkPKUtY0z2vX5LzhrRywLyDQnXaB_mkDI6umScMB9pGGnEh8dMbY5oJxohQTwEjDTlaHGmOVD0MGccjxQmONgM_t_IvmTSEoEW-hFszHS0OJXBO_JmtFOC96d6QX5--_rj6qa6u_9-e_XlrnKSsVw1UvVS-6HTLQy27bhXLTjZCTFYELx3XnBrR92MUozQdaJtvNUtU95JpXnTXJBq3ZueYL8MZh9xZ-PRBIvmNPpVOjCy00x3hf-08vsYfi-QstlhcjBNdoawJCOklI3S5XEFlSvqYkgpwviynDPzrMZszarGPKsxrDdFTYl9PF1Yhh34l9BfFwX4vAJQ_nJAiCY5hNmBxwguGx_w_xf-AFgDo-Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2444378329</pqid></control><display><type>article</type><title>Diagnostic utility of right atrial reservoir strain to identify elevated right atrial pressure in heart failure</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Miah, Nabilah ; Faxén, Ulrika Ljung ; Lund, Lars H. ; Venkateshvaran, Ashwin</creator><creatorcontrib>Miah, Nabilah ; Faxén, Ulrika Ljung ; Lund, Lars H. ; Venkateshvaran, Ashwin</creatorcontrib><description>Accurate non-invasive estimation of right atrial pressure (RAP) is essential to assess volume status and optimize therapy in heart failure (HF). This study aimed to evaluate the utility of right atrial reservoir strain (RASr) assessed by speckle-tracking echocardiography to identify elevated RAP in HF and compare diagnostic performance with estimated RAP employing inferior vena cava size and collapsibility (RAPIVC), in addition to RA area. Association between RASr and invasive RAP (RAPInvasive) was examined in 103 HF subjects that underwent standard echocardiography with speckle-tracking strain analysis directly followed by right heart catheterization. The discriminatory ability of RASr to identify RAPInvasive &gt; 7 mmHg was evaluated and compared with RAPIVC and RA area. RASr demonstrated association with RAPInvasive (β = −0.41, p &lt; 0.001) and was an independent predictor when adjusted for potential confounders (β = −0.25, p &lt; 0.001). Further, RASr showcased strong discriminatory ability to identify subjects with RAPInvasive &gt; 7 mmHg (AUC = 0.78; 95% CI 0.68–0.87; p &lt; 0.001). At a cut-off value of −15%, RASr displayed 78% sensitivity and 72% specificity to identify elevated RAPInvasive. In comparison, RAPIVC (AUC = 0.71; 95% CI 0.61–0.81; p &lt; 0.001) demonstrated 89% sensitivity and 32% specificity with high false positive rate. RA area (AUC = 0.66; 95% CI 0.55–0.76, p = 0.005) displayed 64% sensitivity and 53% specificity. RASr demonstrates good ability to identify elevated RAP and relatively stronger diagnostic performance when compared with conventional non-invasive measures. RASr may be useful as a novel noninvasive estimate of RAP in HF management. •We explored the utility of right atrial strain (RASr) to identify elevated right atrial pressure (RAP) in heart failure.•RASr demonstrated good feasibility and strong diagnostic performance as compared with conventional echo measures.•RASr is a novel, non-invasive identifier of elevated RAP with potential applications in heart failure management.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2020.09.008</identifier><identifier>PMID: 32941871</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Central venous pressure ; Haemodynamics ; Heart failure ; Speckle tracking echocardiography ; Strain imaging</subject><ispartof>International journal of cardiology, 2021-02, Vol.324, p.227-232</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-347948db685eba561d75ec4622bae219cd21aaf83f42fe66253da8507dc478133</citedby><cites>FETCH-LOGICAL-c400t-347948db685eba561d75ec4622bae219cd21aaf83f42fe66253da8507dc478133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2020.09.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32941871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:145887110$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Miah, Nabilah</creatorcontrib><creatorcontrib>Faxén, Ulrika Ljung</creatorcontrib><creatorcontrib>Lund, Lars H.</creatorcontrib><creatorcontrib>Venkateshvaran, Ashwin</creatorcontrib><title>Diagnostic utility of right atrial reservoir strain to identify elevated right atrial pressure in heart failure</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Accurate non-invasive estimation of right atrial pressure (RAP) is essential to assess volume status and optimize therapy in heart failure (HF). This study aimed to evaluate the utility of right atrial reservoir strain (RASr) assessed by speckle-tracking echocardiography to identify elevated RAP in HF and compare diagnostic performance with estimated RAP employing inferior vena cava size and collapsibility (RAPIVC), in addition to RA area. Association between RASr and invasive RAP (RAPInvasive) was examined in 103 HF subjects that underwent standard echocardiography with speckle-tracking strain analysis directly followed by right heart catheterization. The discriminatory ability of RASr to identify RAPInvasive &gt; 7 mmHg was evaluated and compared with RAPIVC and RA area. RASr demonstrated association with RAPInvasive (β = −0.41, p &lt; 0.001) and was an independent predictor when adjusted for potential confounders (β = −0.25, p &lt; 0.001). Further, RASr showcased strong discriminatory ability to identify subjects with RAPInvasive &gt; 7 mmHg (AUC = 0.78; 95% CI 0.68–0.87; p &lt; 0.001). At a cut-off value of −15%, RASr displayed 78% sensitivity and 72% specificity to identify elevated RAPInvasive. In comparison, RAPIVC (AUC = 0.71; 95% CI 0.61–0.81; p &lt; 0.001) demonstrated 89% sensitivity and 32% specificity with high false positive rate. RA area (AUC = 0.66; 95% CI 0.55–0.76, p = 0.005) displayed 64% sensitivity and 53% specificity. RASr demonstrates good ability to identify elevated RAP and relatively stronger diagnostic performance when compared with conventional non-invasive measures. RASr may be useful as a novel noninvasive estimate of RAP in HF management. •We explored the utility of right atrial strain (RASr) to identify elevated right atrial pressure (RAP) in heart failure.•RASr demonstrated good feasibility and strong diagnostic performance as compared with conventional echo measures.•RASr is a novel, non-invasive identifier of elevated RAP with potential applications in heart failure management.</description><subject>Central venous pressure</subject><subject>Haemodynamics</subject><subject>Heart failure</subject><subject>Speckle tracking echocardiography</subject><subject>Strain imaging</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1DAQhi0EotvCGyDkI5ektuPEzgUJtUArVeoFzpZjT9pZsvFiO1vt2-MqSyUunGY0-v4ZaT5CPnBWc8a7y22NW2ejrwUTrGZ9zZh-RTZcK1lx1crXZFMwVbVCNWfkPKUtY0z2vX5LzhrRywLyDQnXaB_mkDI6umScMB9pGGnEh8dMbY5oJxohQTwEjDTlaHGmOVD0MGccjxQmONgM_t_IvmTSEoEW-hFszHS0OJXBO_JmtFOC96d6QX5--_rj6qa6u_9-e_XlrnKSsVw1UvVS-6HTLQy27bhXLTjZCTFYELx3XnBrR92MUozQdaJtvNUtU95JpXnTXJBq3ZueYL8MZh9xZ-PRBIvmNPpVOjCy00x3hf-08vsYfi-QstlhcjBNdoawJCOklI3S5XEFlSvqYkgpwviynDPzrMZszarGPKsxrDdFTYl9PF1Yhh34l9BfFwX4vAJQ_nJAiCY5hNmBxwguGx_w_xf-AFgDo-Y</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Miah, Nabilah</creator><creator>Faxén, Ulrika Ljung</creator><creator>Lund, Lars H.</creator><creator>Venkateshvaran, Ashwin</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20210201</creationdate><title>Diagnostic utility of right atrial reservoir strain to identify elevated right atrial pressure in heart failure</title><author>Miah, Nabilah ; Faxén, Ulrika Ljung ; Lund, Lars H. ; Venkateshvaran, Ashwin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-347948db685eba561d75ec4622bae219cd21aaf83f42fe66253da8507dc478133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Central venous pressure</topic><topic>Haemodynamics</topic><topic>Heart failure</topic><topic>Speckle tracking echocardiography</topic><topic>Strain imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miah, Nabilah</creatorcontrib><creatorcontrib>Faxén, Ulrika Ljung</creatorcontrib><creatorcontrib>Lund, Lars H.</creatorcontrib><creatorcontrib>Venkateshvaran, Ashwin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miah, Nabilah</au><au>Faxén, Ulrika Ljung</au><au>Lund, Lars H.</au><au>Venkateshvaran, Ashwin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic utility of right atrial reservoir strain to identify elevated right atrial pressure in heart failure</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>324</volume><spage>227</spage><epage>232</epage><pages>227-232</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>Accurate non-invasive estimation of right atrial pressure (RAP) is essential to assess volume status and optimize therapy in heart failure (HF). This study aimed to evaluate the utility of right atrial reservoir strain (RASr) assessed by speckle-tracking echocardiography to identify elevated RAP in HF and compare diagnostic performance with estimated RAP employing inferior vena cava size and collapsibility (RAPIVC), in addition to RA area. Association between RASr and invasive RAP (RAPInvasive) was examined in 103 HF subjects that underwent standard echocardiography with speckle-tracking strain analysis directly followed by right heart catheterization. The discriminatory ability of RASr to identify RAPInvasive &gt; 7 mmHg was evaluated and compared with RAPIVC and RA area. RASr demonstrated association with RAPInvasive (β = −0.41, p &lt; 0.001) and was an independent predictor when adjusted for potential confounders (β = −0.25, p &lt; 0.001). Further, RASr showcased strong discriminatory ability to identify subjects with RAPInvasive &gt; 7 mmHg (AUC = 0.78; 95% CI 0.68–0.87; p &lt; 0.001). At a cut-off value of −15%, RASr displayed 78% sensitivity and 72% specificity to identify elevated RAPInvasive. In comparison, RAPIVC (AUC = 0.71; 95% CI 0.61–0.81; p &lt; 0.001) demonstrated 89% sensitivity and 32% specificity with high false positive rate. RA area (AUC = 0.66; 95% CI 0.55–0.76, p = 0.005) displayed 64% sensitivity and 53% specificity. RASr demonstrates good ability to identify elevated RAP and relatively stronger diagnostic performance when compared with conventional non-invasive measures. RASr may be useful as a novel noninvasive estimate of RAP in HF management. •We explored the utility of right atrial strain (RASr) to identify elevated right atrial pressure (RAP) in heart failure.•RASr demonstrated good feasibility and strong diagnostic performance as compared with conventional echo measures.•RASr is a novel, non-invasive identifier of elevated RAP with potential applications in heart failure management.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32941871</pmid><doi>10.1016/j.ijcard.2020.09.008</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0167-5273
ispartof International journal of cardiology, 2021-02, Vol.324, p.227-232
issn 0167-5273
1874-1754
language eng
recordid cdi_swepub_primary_oai_swepub_ki_se_468086
source ScienceDirect Journals (5 years ago - present)
subjects Central venous pressure
Haemodynamics
Heart failure
Speckle tracking echocardiography
Strain imaging
title Diagnostic utility of right atrial reservoir strain to identify elevated right atrial pressure in heart failure
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T15%3A00%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnostic%20utility%20of%20right%20atrial%20reservoir%20strain%20to%20identify%20elevated%20right%20atrial%20pressure%20in%20heart%20failure&rft.jtitle=International%20journal%20of%20cardiology&rft.au=Miah,%20Nabilah&rft.date=2021-02-01&rft.volume=324&rft.spage=227&rft.epage=232&rft.pages=227-232&rft.issn=0167-5273&rft.eissn=1874-1754&rft_id=info:doi/10.1016/j.ijcard.2020.09.008&rft_dat=%3Cproquest_swepu%3E2444378329%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2444378329&rft_id=info:pmid/32941871&rft_els_id=S0167527320337426&rfr_iscdi=true